A Brief Overview of the management of Steroid-Sensitive Nephrotic Syndrome in Children

Management of steroid sensitive nephrotic syndrome (SSNS) in the paediatric age group poses many challenges, which are not limited to steroid toxicity and suboptimal control of proteinuria but also include obtaining long term remission and improving quality of life. Though steroids are the mainstay of treatment for SSNS, various other immunosuppressant medications have been used to achieve remission in frequently relapsing and steroid dependent nephrotic syndrome patients. Selection of these medications should be done carefully, weighing their toxicity profiles and relative effectiveness. This clinical update discusses the disease SSNS and the different treatment strategies that have been evaluated along with their therapeutic outcomes