References
- Gallo A, Pellegrino S, Lipari A, Pero E, Ibba F, Cacciatore S, Marzetti E, Landi F, Montalto M. Lactose malabsorption and intolerance: What is the correct management in older adults? Clinical Nutrition. 2023 Dec 1;42(12):2540-5. https://doi.org/10.1016/j.clnu.2023.10.014 PMid:37931373
- Ponte PR, de Medeiros PH, Havt A, Caetano JA, Cid DA, de Moura Gondim Prata M, Soares AM, Guerrant RL, Mychaleckyj J, Lima AÂ. Clinical evaluation, biochemistry and genetic polymorphism analysis for the diagnosis of lactose intolerance in a population from northeastern Brazil. Clinics. 2016 Feb;71(2):82-9. https://doi.org/10.6061/clinics/2016(02)06 PMid:26934237
- Mattar R, do Socorro Monteiro M, Villares CA, dos Santos AF, Carrilho FJ. Single nucleotide polymorphism C/T-13910, located upstream of the lactase gene, associated with adult-type hypolactasia: validation for clinical practice. Clinical biochemistry. 2008 May 1;41(7-8):628-30. https://doi.org/10.1016/j.clinbiochem.2008.01.006 PMid:18237552
- Bernardes-Silva CF, Pereira AC, da Mota GD, Krieger JE, Laudanna AA. Lactase persistence/non-persistence variants, C/T_13910 and G/A_22018, as a diagnostic tool for lactose intolerance in IBS patients. Clinica chimica acta. 2007 Nov 1;386(1-2):7-11. https://doi.org/10.1016/j.cca.2007.07.012 PMid:17706627
- Pimentel M, Kong Y, Park S. Breath testing to evaluate lactose intolerance in irritable bowel syndrome correlates with lactulose testing and may not reflect true lactose malabsorption. Official journal of the American College of Gastroenterology| ACG. 2003 Dec 1;98(12):2700-4. https://doi.org/10.1111/j.1572-0241.2003.08670.x PMid:14687820
- Bond JH, Levitt MD. Quantitative measurement of lactose absorption. Gastroenterology. 1976 Jun 1;70(6):1058-62. https://doi.org/10.1016/S0016-5085(76)80311-3 PMid:1269865
- Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Järvelä I. Identification of a variant associated with adult-type hypolactasia. Nature genetics. 2002 Feb;30(2):233-7. https://doi.org/10.1038/ng826 PMid:11788828
- Pérez-Jeldres T, Bustamante ML, Segovia-Melero R, Aguilar N, Magne F, Ascui G, Uribe D, Azócar L, Hernández-Rocha C, Estela R, Silva V. Genotype Prevalence of Lactose Deficiency, Vitamin D Deficiency, and the Vitamin D Receptor in a Chilean Inflammatory Bowel Disease Cohort: Insights from an Observational Study. International Journal of Molecular Sciences. 2023 Oct 3;24(19):14866. https://doi.org/10.3390/ijms241914866 PMid:37834314 PMCid:PMC10573577
- Santonocito C, Scapaticci M, Guarino D, Annicchiarico EB, Lisci R, Penitente R, Gasbarrini A, Zuppi C, Capoluongo E. Lactose intolerance genetic testing: Is it useful as routine screening? Results on 1426 south-central Italy patients. Clinica Chimica Acta. 2015 Jan 15;439:14-7. https://doi.org/10.1016/j.cca.2014.09.026 PMid:25281930
- Mattar R, do Socorro Monteiro M, Villares CA, dos Santos AF, Carrilho FJ. Single nucleotide polymorphism C/T-13910, located upstream of the lactase gene, associated with adult-type hypolactasia: validation for clinical practice. Clinical biochemistry. 2008 May 1;41(7-8):628-30. https://doi.org/10.1016/j.clinbiochem.2008.01.006 PMid:18237552
- Bodlaj G, Stocher M, Hufnagl P, Hubmann R, Biesenbach G, Stekel H, Berg J. Genotyping of the lactase-phlorizin hydrolase− 13910 polymorphism by LightCycler PCR and implications for the diagnosis of lactose intolerance. Clinical Chemistry. 2006 Jan 1;52(1):148-51. https://doi.org/10.1373/clinchem.2005.057240 PMid:16391332
- Kuchay RA, Thapa BR, Mahmood A, Mahmood S. Effect of C/T− 13910 cis-acting regulatory variant on expression and activity of lactase in Indian children and its implication for early genetic screening of adult-type hypolactasia. Clinica Chimica Acta. 2011 Oct 9;412(21-22):1924-30. https://doi.org/10.1016/j.cca.2011.06.032 PMid:21763294
- Itan Y, Powell A, Beaumont MA, Burger J, Thomas MG. The origins of lactase persistence in Europe. PLoS computational biology. 2009 Aug 28;5(8):e1000491. https://doi.org/10.1371/journal.pcbi.1000491 PMid:19714206 PMCid:PMC2722739
- Mulcare CA, Weale ME, Jones AL, Connell B, Zeitlyn D, Tarekegn A, Swallow DM, Bradman N, Thomas MG. The T allele of a single-nucleotide polymorphism 13.9 kb upstream of the lactase gene (LCT)(C− 13.9 kbT) does not predict or cause the lactase-persistence phenotype in Africans. The American Journal of Human Genetics. 2004 Jun 1;74(6):1102-10. https://doi.org/10.1086/421050 PMid:15106124 PMCid:PMC1182074
- Enattah NS, Jensen TG, Nielsen M, Lewinski R, Kuokkanen M, Rasinpera H, El-Shanti H, Seo JK, Alifrangis M, Khalil IF, Natah A. Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture. The American Journal of Human Genetics. 2008 Jan 10;82(1):57-72. https://doi.org/10.1016/j.ajhg.2007.09.012 PMid:18179885 PMCid:PMC2253962
- Mulcare C. The evolution of the lactase persistence phenotype. University of London, University College London (United Kingdom); 2006.
- Bersaglieri T, Sabeti PC, Patterson N, Vanderploeg T, Schaffner SF, Drake JA, Rhodes M, Reich DE, Hirschhorn JN. Genetic signatures of strong recent positive selection at the lactase gene. The American Journal of Human Genetics. 2004 Jun 1;74(6):1111-20. https://doi.org/10.1086/421051 PMid:15114531 PMCid:PMC1182075
- Poulter M, Hollox E, Harvey CB, Mulcare C, Peuhkuri K, Kajander K, Sarner M, Korpela R, Swallow DM. The causal element for the lactase persistence/non-persistence polymorphism is located in a 1 Mb region of linkage disequilibrium in Europeans. Annals of Human Genetics. 2003 Jul;67(4):298-311. https://doi.org/10.1046/j.1469-1809.2003.00048.x PMid:12914565
- Grand RJ, Montgomery RK, Chitkara DK, Hirschhorn JN. Changing genes; losing lactase. Gut. 2003 May 1;52(5):617-9. https://doi.org/10.1136/gut.52.5.617 PMid:12692040 PMCid:PMC1773627
- Lapides RA, Savaiano DA. Gender, age, race and lactose intolerance: is there evidence to support a differential symptom response? A scoping review. Nutrients. 2018 Dec 11;10(12):1956. https://doi.org/10.3390/nu10121956 PMid:30544891 PMCid:PMC6316196
- Santonocito C, Scapaticci M, Guarino D, Annicchiarico EB, Lisci R, Penitente R, Gasbarrini A, Zuppi C, Capoluongo E. Lactose intolerance genetic testing: Is it useful as routine screening? Results on 1426 south-central Italy patients. Clinica Chimica Acta. 2015 Jan 15;439:14-7. https://doi.org/10.1016/j.cca.2014.09.026 PMid:25281930
- Baadkar SV, Mukherjee MS, Lele SS. Study on influence of age, gender and genetic variants on lactose intolerance and its impact on milk intake in adult Asian Indians. Annals of Human Biology. 2014 Nov 1;41(6):548-53. https://doi.org/10.3109/03014460.2014.902992 PMid:24734931
- Raz M, Sharon Y, Yerushalmi B, Birk R. Frequency of LCT-13910C/T and LCT-22018G/A single nucleotide polymorphisms associated with adult-type hypolactasia/lactase persistence among Israelis of different ethnic groups. Gene. 2013 Apr 25;519(1):67-70. https://doi.org/10.1016/j.gene.2013.01.049 PMid:23415628
- AS Arroyo M, P Lopes AC, B Piatto V, Victor Maniglia J. Perspectives for Early Genetic Screening of Lactose Intolerance:-13910C/T Polymorphism Tracking in the Gene. The Open Biology Journal. 2010 Jul 16;3(1). https://doi.org/10.2174/18741967010030100066
- Mattar R, Monteiro MS, Villares CA, Santos AF, Silva JM, Carrilho FJ. Frequency of LCT-13910C> T single nucleotide polymorphism associated with adult-type hypolactasia/lactase persistence among Brazilians of different ethnic groups. Nutrition Journal. 2009 Dec;8:1-3. https://doi.org/10.1186/1475-2891-8-46 PMid:19799794 PMCid:PMC2761420
- Boschmann SE, Boldt AB, De Souza IR, Petzl-Erler ML, Messias-Reason IJ. The frequency of the LCT*-13910C> T polymorphism associated with lactase persistence diverges among Euro-Descendant groups from Brazil. Medical Principles and Practice. 2015 Dec 1;25(1):18-20. https://doi.org/10.1159/000440807 PMid:26334798 PMCid:PMC5588315