
Figure 1.
Systematic review flow diagram based on PRISMA guidelines.
Table 1.
List of studies included in the review.
| No. | Author / Year | Final sample (n) | Study design | Quality of interaction measures Data collection method / Infant’s age at measuring interaction | Outcome domain Data collection method /Child’s age at measuring the outcome | Main findings (↑= ↓ negative correlation, ↑= ↑ positive correlation) |
|---|---|---|---|---|---|---|
| 1. | A. Bernier, S. D. Calkins, M. A. Bell (2016) | n= 197 mother-infant dyads (healthy full-term infants) | Longitudinal study | Maternal behavior: sensitivity, intrusiveness, positive affect, physical stimulation coding scheme developed by Calkins, Hungerford, and Dedmon (2004)/ 5 months | Resting EEG power/ 5, 10 and 24 months | ↑ Quality of maternal behavior during mother—infant interactions = ↑frontal resting EEG power |
| 2. | J. R. Britton, H. L. Britton, V. Gronwaldt (2006) | n= 152 mother-infant dyads (healthy full-term infants) | Longitudinal study | Quality of the dyadic interaction scales Nursing Child Assessment Satellite Training (NCAST) Feeding Scale/ 6 months | Security of infant-mother attachment. Ainsworth Strange Situation Procedure/ 12 months | ↑Quality of the dyadic interaction = ↑security of attachment |
| 3. | R. Costa, B. Figueiredo (2011) | n= 94 mother-infant dyads (7,2% preterm infants, 92,8% full-term infants) | Longitudinal study | Quality of the overall mother–infant interaction (good vs poor) The Global Rating Scales (GRS)/ 2 months (+/−5 days) | Temperament The Infant Behavior Questionnaire - Revised (IBQ-R)- The Portuguese version/ 3 and 12 months | Poor mother–infant interaction = ↓mothers’ perception of infant high pleasure and smile and ↑ mothers’ perceptions of infant level of activity |
| 4. | J. S. Crawford (2004) | n= 65 mother-infant dyads (no information about GA) | Cross-sectional study | Maternal responsivity/sensitivity Synchrony/reciprocity of parent-child interactions 7-point Likert scales/ between 6 and 12 months | Temperament. The Infant Behavior Questionnaire- Revised (IBQ-R) and Temperament Laboratory Assessment (TLA)/ between 6 and 12 months | ↑Maternal responsivity/sensitivity = ↑child’s attentional skills (Perceptual sensitivity) |
| 5. | E. P. Davis et al. (2018) | Irvine Cohort: n1=192 mother-infant dyads Turku Cohort: n2=126 mother-infant dyads (infants selected from bigger “FinnBrain” Cohort, no information about GA) | Longitudinal cohort study | Degree of predictability of maternal sensory signals The entropy rate/ 6, 8 and 12 months | Child self-control Infant Behavior Questionnaire - Revised (IBQ-R)/ 1 year, Children’s Behavior Questionnaire (CBQ)/ 5 years, Flanker task/ 6,5 years, Temperament in Early Childhood Questionnaire (TMCQ)/ 9,5 years | ↑ Unpredictable maternal sensory signals (high entropy rate) = ↓ child self-control |
| 6. | S. J. Erickson, J. R. Lowe (2008) | n= 50 mother-infant dyads (VLBW preterm infants: birth weight < 1,250 g.) | Cross-sectional study | Interactive maternal behaviors Still Face (SF) Tronick et al.’s (1978) protocol/ between 6 and 8 months |
| Positive infant affect during and after the SF stressor was related to baseline infant positive affect and ↑ maternal responsiveness |
| 7. | C. A. Evans, C. L. Porter (2009) | n ranged from 101 to 84, mother–infant dyads (healthy full-term infants) | Longitudinal study | Mother-infant co-regulation Fogel’s Relational Coding System/ 6, 9 and 12 months |
| Symmetrical co-regulation = ↑ MDI scores. Asymmetrical and Unilateral co-regulation = ↓ MDI scores Symmetrical co-regulation = ↑PDI scores, Unengaged behaviors = ↓ PDI scores |
| 8. | R. Feldman (2007) | n= 31 mother-infant dyads (healthy full-term infants) | Longitudinal study | Mother-infant synchrony. Mutual influence assessed with time-series analysis (CCF cross corelation function)/ 3 and 9 months |
| ↑ Mother-infant synchrony — ↑ mutual influence, ↑ verbal IQ, ↑ behavior problems and ↑ capacity for empathy in adolescence, ↑ Mutual influence = ↑ self- regulated compliance and ↑ capacity for empathy in adolescence |
| 9. | R. Feldman (2010) | n= 36 mother-infant dyads (healthy full-term infants) | Longitudinal study | Maternal sensitivity Child social engagement Mother intrusiveness Dyadic reciprocity Coding Interactive behavior manual (CIB)/ 3 and 9 months, 2, 4, 6, and 13 years. |
| ↓Maternal sensitivity across development and ↑ Intrusiveness = ↓ adolescents’ adaptation ↑Dyadic reciprocity = ↑ adolescent adjustment. |
| 10. | R. Feldman et al. (2013) |
| Longitudinal study | Early Parental Care Proportions of gaze to infant, positive affect, ‘motherese’ vocalizations, and affectionate touch were summed into a parent care composite/ 1 and 6 months |
| ↑Early maternal care = ↑ mother-child reciprocity (early paternal care was unrelated to father-child reciprocity) ↑Mother-child reciprocity = ↑ Children’s social reciprocity with best friend (father-child reciprocity was unrelated) |
| 11. | R. Feldman, E. Bamberger, Y. Kanat-Maymon (2013) | n ranged from 100 to 68; mother/father-infant dyads (healthy full-term infants) | Longitudinal study | Parent-child reciprocity Coding Interactive Behavior manual (CIB)/ 5 months, 3 and 13 years. |
| ↑Early maternal and paternal reciprocity = ↑ social competence, ↓aggression in preschool, ↑dialogical skills in adolescence (Father—adolescent reciprocity contributed to the dialogical negotiation of conflict, whereas mother-adolescent reciprocity predicted adolescents’ dialogical skills during positive exchanges.) |
| 12. | R Feldman (2015) | n= 125 mother-infants dyads (healthy premature infants: GA between 25 and 35 weeks) | Longitudinal study | Parent-child reciprocity Coding Interactive Behavior manual (CIB)/ 3, 6, 12, and 24 months and 5 years |
| ↑ Parent-child reciprocity = ↑ child ER, ↑Reciprocity = ↑ greater empathy |
| 13. | C. Giovanelli et al. (2020) | n= 43 mother-infant dyads(no information about GA) | Longitudinal study | Mind-mindedness Meins and Fernyhough’s coding system (1977)/ 6 and 12 months | Symbolic play The coding system developed by McCune-Nicolich (1977)/ 12 and 13 months | ↑ Mind-related comments = ↑ length and maturity level of infants’ symbolic play |
| 14. | M. Kivijärvi et al. (2005) | n= 56 mother-infant dyads (healthy full-term infants) | Longitudinal study | Maternal sensitivity behavior (MSB) Parent-Child Early Relational Assessment (PCERA)/ 3 and 12 months | Temperament PCERA infant items/ 3 months Revised Infant Temperament Questionnaire (R-ITQ)/ 6 months Toddler Temperament Questionnaire (TTQ)/ 12 months |
|
| 15. | M. F. Lorber, B. Egeland (2011) | n ranged from 267 to 243, mother–child dyads (no information about GA, infants assessed at home at their 7th day of life= probably full-term infants ) | Longitudinal study | Negative infancy parenting. Ratings of positive and negative maternal regard for the infant on 7-point scales/ 3 and 6 months (common variance) |
| ↑Negative mothering = ↑mutually angry and hostile mother–toddler interaction, and ↑CPs |
| 16. | J. Milgrom et al. (2013) | m = 109 mothers with n=123 infants (preterm infants <30 weeks GA - Intervention group: m1= 54 mothers, n1 = 60 infants. Control group: m2= 55 mothers n2= 63 infants) | RCT (enhanced MITP intervention group vs. control group) | Maternal sensitivity Preterm Mother–Infant Interaction Scale (PREMIIS)/ term-equivalent age | Infant communication abilities The Infant–Toddler Checklist of the Communication and Symbolic Behaviour Scales Developmental Profile (CSBS DP Infant–Toddler Checklist)/ 6 months CA | Experimental (MITP intervention) group: ↑ symbolic behaviour |
| 17. | J. Milgrom, D. T. Westley, A. W. Gemmill (2004) | n ranged from 88 to 56, mother-infant dyads: n, ranged from 40 to 23 (depressed mothers), n2 ranged from 48 to 33 (control mothers), no information about infants’ GA | Cross-sectional study | Maternal responsiveness measure adapted by Milgrom and Burn (1988)/ 6 months |
| Depressed mothers group: ↓ mother-infant interactions and ↑ child’s temperamental difficulties (but not correlated with maternal responsiveness) ↓Maternal responsiveness = ↑ cognitive deficits |
| 18. | C A, Newnham, J. Milgrom, H. Skouteris (2009) | n= 68 mother-infant dyads (preterm infants; Intervention group: n1= 35 (mean GA= 31.26), Control group: n2= 33 (mean GA= 33.71) | RCT (MITP-based intervention group vs control group) | Maternal respond, Infant alert, Attending to mother. Mutual attention, Reciprocity/Synchrony Synchrony Scale/ 3 and 6 months CA |
|
|
| 19. | K. A. O’Donnell H. Gaudreau (2014) | n ranged from 213 to 109, mother- infant dyads (healthy full-term infants) | Longitudinal study | Maternal sensitivity Ainsworth Maternal Sensitivity Scales 6 and 18 months Maternal behavior: duration of looking away from the infant, vocalizing to the infant Behavioural Evaluation Strategies and Taxonomies coding system/ 6 months |
| No correlation was found between maternal sensitivity or maternal behavior and children’s attachment security. |
| 20. | J Poehlman n, B. H. Fiese (2001) | n= 84 infant-mother dyads (n1 =44 full-term infants, n2= 20 preterm LBW infants <2500 g, n3= 20 preterm VLBW infants < 1500 g ) | Longitudinal cohort study | Quality of parent-infant interaction The Pediatric Infant Parent Exam (PIPE)/ 6 months | Infant developmental abilities The Mental Scale (MDI) of the Bayley Scales of Infant Development/ 12 months | ↑ Reciprocal, ↑affectively positive and ↑engaging interactions = ↑ Infant developmental abilities |
| 21. | V. Sethna et al. (2017) | n= 39 mother-infant dyads (healthy full-term infants) | Cross-sectional study | Maternal sensitivity and affect, Quality of parent-infant relationship, Infant communication and affective state Global Rating Scales (GRS)/ between 3 and 6 months | Dimensions and brain volumes MRI data acquisition/ between 3 and 6 months |
|
| 22. | P. E, Shah, et al. (2013) | n= 123 mother-infant dyads (n1 = 39 very preterm infants (VPI ), n2= 47 moderate preterm infants (MPI), n3=37 late preterm infants (LPI) | Longitudinal study | Maternal parenting Parent Child Early Relational Assessment (PCERA)/ 4, 9, 16, and 24 months |
| ↑Negative parenting = ↑ externalizing behavior problems ↑Maternal negative behavior = ↓ optimal child IQ (VPIs). ↓ Negative interactions during infancy = ↑ cognitive skills (VPIs) |
| 23. | D. Silberstein et al. (2009) | n= 76 mother-infant dyads (low-risk premature infants: mean GA of 32.5 weeks) | Longitudinal study | Maternal touch and gaze Maternal adaptation Coding of Interactive Behavior-Newborn (CIB)/ Prior to hospital discharge Infant developmental status: psychomotor (PDI) and mental (MDI) development Bayley Scales of Infant Development, 2nd edition/ 4 months | I. Feeding difficulties Maternal interview and direct observations of feeding interactions/ 1 year | ↑Maternal intrusiveness, ↓affectionate touch and gaze, ↑gaze aversion and ↓maternal adaptation = ↑feeding difficulties |
| 24. | S. Stolt et al. (2014) | n= 62 mother-infant dyads (n1=28 VLBW infants = birth weight ≤ 1500 g, n2= 34 full-term infants ) | Longitudinal cohort study | Quality of mother-child Interaction scales The Parent-child Early Relational Assessment (the PCERA)/ 6 and 12 months (CA for VLBW infants) | Early language development Checklist for the Development of Early Vocalizations (CDEV) + Finnish version of the MacArthur Communicative Development Inventory (CDI; FinCDI)/ 6, 12 and 24 month (CA for VLBW infants) | ↑ Maternal positive affective involvement = ↑number of morphological inflections ↑Infants positive affect = ↑number of morphological inflections ↑ Maternal positive communication = ↑language skills ↑Dyadic features = ↑language skills |
| 25. | M. T. Tu et al. (2007) | n= 158 mother-infant dyads (n1= 103 VLGA infants= ≤32 weeks GA, n2=55 full-term infants ) | Longitudinal cohort study | Interactive maternal behaviors: Gratification, Affect, Sensitivity, and Organization. criteria set by Crnic et al. (1983)/ 8 months CA |
| ↑Interactive maternal behavior = ↑focused attention (preterm/low parenting stress group) ↑Interactive maternal behavior = ↓basal cortisol and ↓ quality of focused attention (preterm/high parenting stress group) |
| 26. | E. van de Weijer-Bergsma et al. (2016) | n= 74 mother-infant dyads (preterm infants; ≤36 weeks GA with a birth weight of <2500g) | Longitudinal study | Maternal sensitive responsiveness and directiveness ELO scales/ 7, 10 and 14 months CA | Executive functioning looking and reaching versions of the A-not-B task/ 7, 10 and 14 months CA | ↑ Maternal directiveness and stability in maternal directiveness = ↑ (faster) developmental change in A-not-B performance |
| 27. | F. F. Warnock et al. (2016) | n= 24 mother-infant dyads (healthy full-term infants) | Cross-sectional study | Maternal caregiving behavior Maternal Behavior Coding System (MBCS)/ second visit after hospital discharge | Infant pain behavior self-regulation Neonatal Distress Pain Related Behavioral Coding Schema (ND-BSC)/ second visit after hospital discharge | Atypical maternal caregiving behavior was related to atypical infant pain behavior self-regulation during and after the heel lance procedure. |
| 28. | A. Wazana et al. (2015) | n= 650 mother-infant dyads (healthy full-term infants) | Longitudinal study | Maternal sensitivity Ainsworth Maternal Sensitivity Scales Maternal behavior: frequency and duration of looking away from the infant, vocalizing to the infant, instrumental caregiving Behavioural Evaluation Strategies and Taxonomies coding system/ Both 6 months |
| ↑ Attentive maternal care (frequency of maternal looking away behavior) and ↓ Sensitivity = disorganized attachment of children in the midrange of birth weight. The association reversed with extreme birth weight (low and high). |
| 29. | D. Wolke, S. Eryigit-Madzwamuse, T. Gutbrod (2014) | n=176 mother-infant dyads; n1= 71 VP/VLBW infants: <1500 g or <32 weeks of gestation), n2= 105 full-term infants | Longitudinal cohort study | Maternal sensitivity Boston City Hospital Assessment of Parental Sensitivity (BCHAPS)/ at term Mother-Infant Structured Play Assessment/ 3 months | Infant attachment Strange Situation Assessment (SSA)/ 18 months | ↓ Maternal sensitivity at term (full-term sample) = ↑ attachment disorganization |
| 30. | M. A. J. Zeegers et al. (2018) | n ranged from 135 to 130 infants; mother/father – infant dyads (healthy infants = birth weight > 2500 g) | Longitudinal study | Parental mind-mindedness Mind-mindedness coding manual 4 and 12 months Parenting quality Meso Behavioural Rating System for Families with young children (MeBRF)/ 12 months |
| Both mothers’ and fathers’ appropriate mind-related comments = ↑infant baseline HRV (for fathers indirect association via parenting quality) Mothers’ appropriate mind-related comments and fathers’ non-attuned mind-related comments = ↑ HRV decline during the stranger approach |

Figure 2.
Significant direct interrelations between the level of early mother-infant interaction quality and physiology-related developmental outcomes found within the scope of articles included in this review.
*no studies which include correlation with physiological or neurodevelopmental outcome.
**eating difficulties according to the current terminology.

Figure 3.
Significant direct interrelations between the level of early mother-infant interaction quality and cognitive-related developmental outcomes found within the scope of articles included in this review.
*no studies which include correlation with cognitive or socio-emotional outcome.
**Social skills include three different variables found in articles: social skills, social reciprocity and symbolic play development.
| No. | Author/Year | Selection Bias | Study Design | Confounders | Blinding | Data Collection Method | Withdrawals and Dropouts | Global Rating |
|---|---|---|---|---|---|---|---|---|
| 1. | A. Bernier, S. D. Calkins, M. A. Bell (2016) | Moderate | Moderate | Strong | Moderate | Strong | Weak | Moderate |
| 2. | J. R. Britton, H. L. Britton, V. Gronwaldt (2006) | Moderate | Moderate | Moderate | Moderate | Strong | Weak | Moderate |
| 3. | R. Costa, B. Figueiredo (2011) | Strong | Moderate | Strong | Moderate | Strong | Weak | Moderate |
| 4. | J. S. Crawford (2004) | Moderate | Moderate | Moderate | Moderate | Strong | Moderate | Strong |
| 5. | E. P. Davis et al. (2018) | Moderate | Moderate | Strong | Moderate | Strong | Moderate | Strong |
| 6. | S. J. Erickson, J. R. Lowe (2008) | Weak | Moderate | Strong | Moderate | Strong | Weak | Weak |
| 7. | C. A. Evans, C. L. Porter (2009) | Weak | Moderate | Strong | Moderate | Strong | Strong | Moderate |
| 8. | R. Feldman (2007) | Moderate | Moderate | Strong | Moderate | Strong | Strong | Strong |
| 9. | R. Feldman (2010) | Moderate | Moderate | Strong | Moderate | Strong | Strong | Strong |
| 10. | R. Feldman et al. (2013) | Weak | Moderate | Strong | Moderate | Strong | Moderate | Moderate |
| 11. | R. Feldman, E. Bamberger, Y. Kanat-Maymon (2013) | Moderate | Moderate | Moderate | Moderate | Strong | Moderate | Strong |
| 12. | R. Feldman (2015) | Moderate | Moderate | Strong | Moderate | Strong | Moderate | Strong |
| 13. | C. Giovanelli et al. (2020) | Weak | Moderate | Strong | Moderate | Strong | Strong | Moderate |
| 14. | M. Kivijärvi et al. (2005) | Moderate | Moderate | Strong | Moderate | Strong | Strong | Strong |
| 15. | M. F. Lorber, B. Egeland (2011) | Weak | Moderate | Strong | Moderate | Strong | Strong | Moderate |
| 16. | J. Milgrom et al. (2013) | Weak | Strong | Strong | Moderate | Strong | Strong | Moderate |
| 17. | J. Milgrom, D. T. Westley, A. W. Gemmill (2004) | Moderate | Strong | Moderate | Moderate | Strong | Moderate | Strong |
| 18. | C. A. Newnham, J. Milgrom, H. Skouteris (2009) | Strong | Strong | Strong | Moderate | Strong | Strong | Strong |
| 19. | K. A. O’Donnell, H. Gaudreau (2014) | Moderate | Moderate | Strong | Moderate | Strong | Weak | Moderate |
| 20. | J. Poehlmann, B. H. Fiese (2001) | Moderate | Moderate | Strong | Moderate | Strong | Moderate | Strong |
| 21. | V. Sethna et al. (2017) | Weak | Moderate | Stong | Moderate | Strong | Strong | Moderate |
| 22. | P. E. Shah, et al. (2013) | Moderate | Moderate | Stong | Moderate | Strong | Strong | Strong |
| 23. | D. Silberstein et al. (2009) | Moderate | Moderate | Strong | Moderate | Strong | Strong | Strong |
| 24. | S. Stolt et al. (2014) | Moderate | Moderate | Weak | Moderate | Strong | Strong | Moderate |
| 25. | M. T. Tu et al. (2007) | Moderate | Moderate | Strong | Moderate | Strong | Weak | Moderate |
| 26. | E. van de Weijer-Bergsma et al. (2016) | Moderate | Moderate | Weak | Moderate | Strong | Strong | Moderate |
| 27. | F. F. Warnock et al. (2016) | Moderate | Moderate | Strong | Moderate | Strong | Moderate | Strong |
| 28. | A. Wazana et al. (2015) | Moderate | Moderate | Strong | Moderate | Strong | Strong | Strong |
| 29. | D. Wolke, S. Eryigit-Madzwamuse, T. Gutbrod (2014) | Strong | Strong | Strong | Moderate | Strong | Strong | Strong |
| 30. | M. A. J. Zeegers et al. (2018) | Weak | Moderate | Strong | Moderate | Strong | Moderate | Moderate |