Epidemiological, Clinical, and Laboratory Features of Children with SARS-CoV-2 in Ukraine

Figures & Tables

Symptoms	Symptom presence	Moderate (n=133)		Severe (n=38)		Total (n=171)		χ² test	p-value

		n	%	n	%	n	%
Fever	<38°c	114	85.71	35	92.11	149	87.13	0.58	0.44
Fever	<38°c	19	14.29	3	7.89	22	12.87	0.58	0.44
Sore throat	+	90	67.67	29	76.32	119	69.59	0.67	0.41
Sore throat	−	43	32.33	9	23.68	52	30.41	0.67	0.41
Cough	+	77	57.89	28	73.68	105	61.40	2.47	0.11
Cough	−	56	42.11	10	26.32	66	38.60	2.47	0.11
Rhinitis	+	73	54.89	27	71.05	100	58.48	2.54	0.11
Rhinitis	−	60	45.11	11	28.95	71	41.52	2.54	0.11
Myalgia	+	42	31.58	26	68.42	68	39.77	15.24	0.0001^*
Myalgia	−	91	68.42	12	31.58	103	60.23	15.24	0.0001^*
Lymphadenopathy	+	37	27.82	16	42.11	53	30.99	2.19	0.13
Lymphadenopathy	−	96	72.18	22	57.89	118	69.01	2.19	0.13
Wheezing	+	41	30.83	10	26.32	51	29.82	0.11	0.73
Wheezing	−	92	69.17	28	73.68	120	70.18	0.11	0.73
Headache	+	24	18.05	15	39.47	39	22.81	6.5	0.01^*
Headache	−	109	81.95	23	60.53	132	77.19	6.5	0.01^*
Diarrhea	+	21	15.79	16	42.10	37	21.63	10.56	0.001^*
Diarrhea	−	112	84.82	22	57.90	134	78.36	10.56	0.001^*
Anosmia	+	17	12.78	1	2.63	18	10.53	2.24	0.13
Anosmia	−	116	87.22	37	97.37	153	89.47	2.24	0.13
Dermatological changes	+	17	12.78	0	0.00	17	9.94	2.24	0.13
Dermatological changes	−	116	87.22	38	100.00	154	90.06	2.24	0.13
Dyspnea	+	2	1.50	12	31.58	14	8.19	31.67	0.00001^*
Dyspnea	−	131	98.50	26	68.42	157	91.81	31.67	0.00001^*
Ageusia	+	9	6.77	1	2.63	10	5.85	0.32	0.57
Ageusia	−	124	93.23	37	97.37	161	94.15	0.32	0.57
Cyanosis	+	0	0.00	5	13.16	5	2.92	10.02	0.001^*
Cyanosis	−	133	100.00	33	86.84	166	97.08	10.02	0.001^*

Comorbidities	Moderate course (n=133)		Severe course (n=38)		Total (n=171)		p-value

	n	%	n	%	n	%
RRI	60	45.11	29	76.31	89	52.04	0.7
Chronic tonsillitis	15	11.28	5	13.16	20	11.7	0.7
CMV	5	3.76	6	15.79	11	6.43	0.9
Anemia	6	4.51	5	13.16	11	6.43	0.5
Atopic dermatitis	7	5.26	4	10.52	9	5.23	0.6
Neurological disorder	3	2.25	5	13.16	8	4.68	0.5
Urinary tract diseases	6	4.51	2	5.26	8	4.68	0.6
Allergy	6	4.51	1	2.63	7	4.09	0.9
Congenital heart disease	5	3.76	1	2.63	6	3.51	0.9
Gastrointestinal diseases	3	2.25	2	5.26	5	2.92	0.5
Obesity	3	2.25	2	5.26	5	2.92	0.5
Epilepsy	2	1.5	3	7.89	5	2.92	0.8
Asthma	3	2.25	1	2.63	4	2.34	0.9
Congenital bone disorders	0	0	2	5.26	2	1.17	0.3
Oncological disease	2	1.5	0	0	2	1.17	0.3
Diabetes	1	0.75	0	0	1	0.58	0.3
HIV	1	0.75	0	0	1	0.58	0.3
UCTD	1	0.75	0	0	1	0.58	0.3

Parameter	Reference values	Moderate (n=133)		Severe (n =38)		Total (n=171)		p-value

		n	%	n	%	n	%
RBC (*10¹² cells/L)	<3.5	2	1.50	3	7.90	5	2.92		0.001^*
	3.5–5.0	71	53.38	22	57.90	93	54.38	0.6
	>5.0	60	45.11	13	34.21	73	42.70	0.2
HGB (g/L)	<110	6	4.51	1	2.63	7	4.09	0.5
	110–140	74	55.64	37	97.37	111	64.91	0.001^*
	>140	53	39.85	0	0.00	53	30.99	0.001
WBC (10⁹ cells/L)*	<5.5	29	21.80	9	23.68	38	22.22	0.6
	5.5–12	81	60.90	20	52.63	101	59.06	0.3
	>12	23	17.29	9	23.68	32	18.71	0.1
Lymphocytes (%)	<45	93	69.92	24	63.16	117	68.42	0.4
	45–65	32	24.06	10	26.32	42	24.56	0.7
	>65	8	6.02	4	10.53	12	7.02	0.4
Eosinophils (%)	<0.5	2	1.50	1	2.63	3	1.75	0.4
	0.5–7	128	96.24	37	97.37	165	96.49	0.6
	>7	3	2.26	0	0.00	3	1.75	0.1
ERS (mm/h)	<10	119	89.47	36	94.74	155	90.64	0.2
ERS (mm/h)	>10	14	10.53	2	5.26	16	9.36	0.2
CRP (mg/L)	<3	72	54.14	8	21.05	80	46.78	0.001^*
CRP (mg/L)	>3	61	45.86	30	78.95	91	53.22	0.001^*
ALT (IU/L)	<40	116	89.23	32	91.48	148	86.59	0.6
ALT (IU/L)	>40	14	10.76	3	8.57	17	10.30	0.6
AST (IU/L)	<40	106	81.53	17	48.57	123	75.54	0.001^*
AST (IU/L)	>40	24	18.46	18	51.42	42	25.45	0.001^*
Creatinine (mmol/L)	<50	65	60.74	25	83.33	91	66.42	0.01
Creatinine (mmol/L)	>50	42	39.25	5	16.66	46	35.57	0.01
Urea (mmol/L)	2.5–6.5	95	88.78	25	83.33	120	87.59	0.5
Urea (mmol/L)	>6.5	12	11.21	5	16.66	17	12.40	0.5