Suspicions regarding the genetic inheritance of acute lymphoblastic leukemia in patients with down syndrome

Behluli, Emir; Nuhii, Nexhibe; Liehr, Thomas; Temaj, Gazmend

doi:10.34763/jmotherandchild.20222601.d-22-00002

Abstract

Children with Down syndrome (DS) are at markedly increased risk for acute lymphoblastic leukaemia (ALL). DS is caused by trisomy of chromosome 21 affecting approximately 1 in 732 newborns in the USA. ALL is the most common cancer in children and constitutes approximately 25% of cancer diagnoses among children under the age of 15. Different protocols for treatment and management of paediatric ALL are available; however, DS children with ALL (DS-ALL) have increased risk of therapy-related toxicity compared to those without DS. Herein, we summarize the available literature on inherited predisposition for ALL, and possibilities for molecular therapy and treatment for DS-ALL patients.

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Suspicions regarding the genetic inheritance of acute lymphoblastic leukemia in patients with down syndrome

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