Score comparison between groups and Receiver Operator Characteristics (ROC) Curve results for significant parameters_ *Mann-Whitney U test; †χ2 test; ‡Fisher exact test; GA – gestational age, WBC – white blood count, PLT – platelet, CRP – C-reactive protein, AUC – area under the curve
| Parameters | Cultural Study (CS) | ROC curve | |||
|---|---|---|---|---|---|
| Negative (n=15) | Positive (n=18) | p value | AUC (95% CI) | p value | |
| GA, median weeks, [inter-quartile range (IQR)] Birthweight, median grams [IQR] | 27.6 [26.6-29.4] 1030 [855-1400] | 28.2 [27.6-30.3] 1043 [940-1360] | - | - | - |
| Median 1st Minute Apgar Score | 6 | 7 | |||
| Median 5th Minute Apgar Score | 7 | 8 | |||
| Median 10th Minute Apgar Score | 8 | 8 | |||
| Post Menstrual Age at Sepsis Suspicion, Median weeks [IQR] | 29.3 [28.1-31.6] | 30.6 [29.4-32.1] | |||
| WBC count at suspicion, median x 10^9/L [IQR] | 21.3 [10.5-23.9] | 16.3 [9-25.1] | 0.391* | - | - |
| PLT count at suspicion, median x 10^9/L [IQR] | 420 [301-549] | 230 [170-325] | 0.024* | 0.767 (0.60-0.94) | 0.011 |
| CRP at suspicion, median mg/L [IQR] | 9.5 [2.2-18.4] | 17.5 [4.9-39.9] | 0.215* | - | - |
| WBC at 2nd timing, median x 10^9/L [IQR] | 17.1 [8.8-23-3] | 14 [10.2-20.3] | 0.862* | - | - |
| PTL at 2nd timing, median x 10^9/L [IQR] | 395 [222-529] | 153 [99-288] | 0.02* | 0.892 (0.78-1) | <0.001 |
| CPR at 2nd timing, median mg/L [IQR] | 5.8 [1.1-14.5] | 40.8 [14.9-82.4] | 0.009* | 0.807 (0.64-0.98) | 0.005 |
| Score at suspicion, median | 2.00 | 3.00 | 1.000* | - | - |
| Score at second timing, median | 2.00 | 5.00 | .021* | 0.798 (0.63-0.97) | 0.007 |
| Higher score in the second measure, n (%) | 3 (21.4%) | 10 (66.7%) | 0.014† | - | - |
| Lower PLT count in the second measure, n (%) | 9 (60%) | 13 (81.3%) | 0.252† | - | - |
| Higher CRP value in the second measure, n (%) | 4 (28.6%) | 12 (75%) | 0.011† | - | - |
| Intubation between both measures, n (%) | 0 | 7 (41.2%) | 0.008‡ | - | - |
| Respiratory score at suspicion, median | 1.00 | 1.00 | 0.798* | - | - |
| Analytical score at suspicion, median | 1.00 | 1.00 | 0.266* | - | - |
| Respiratory score at 2nd timing, median | 1.00 | 2.00 | 0.296* | - | - |
| Analytical score at 2nd timing, median | 1.00 | 3.00 | 0.001* | 0.800 (0.62-0.98) | .006 |