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Hormonal dysfunction in adult patients affected with inherited metabolic disorders Cover

Hormonal dysfunction in adult patients affected with inherited metabolic disorders

Open Access
|Nov 2020

References

  1. Vantyghem MC, Dobbelaere D, Mention K, Wemeau JL, Saudubray JM, Douillard C. Endocrine manifestations related to inherited metabolic diseases in adults. Orphanet J Rare Dis. 2012;7:11. doi: 10.1186/1750-1172-7-11
  2. Sanderson S, Green A, Preece MA, Burton H. The incidence of inherited metabolic disorders in the West Midlands, UK. Arch Dis Child. 2006;91(11):896–9. doi: 10.1136/adc.2005.091637
  3. Stępień KM, Hendriksz CJ. The principles of the transition process from paediatric to adult services in inborn errors of metabolism – own experience. Dev Period Med. 2015;19(4):523–7.
  4. McDermott JH, Walsh CH. Hypogonadism in hereditary hemo-chromatosis. J Clin Endocrinol Metab. 2005;90(4):2451–5. doi: 10.1210/jc.2004-0980
  5. Buretić-Tomljanović A, Vlastelić I, Radojcić Badovinac A, Starcević-Cizmarević N, Nadalin S, Ristić S. The impact of hemo-chromatosis mutations and transferrin genotype on gonadotropin serum levels in infertile men. Fertil Steril. 2009;91(5):1793–800. doi: 10.1016/j.fertnstert.2008.02.129
  6. Giannitrapani L, Soresi M, La Spada E, Cervello M, D’Alessandro N, Montalto G. Sex hormones and risk of liver tumor. Ann N Y Acad Sci. 2006;1089:228–36. doi: 10.1196/annals.1386.044
  7. Wang Y, Busin R, Reeves C, Bezman L, Raymond G, Toomer CJ, et al. X-linked adrenoleukodystrophy: ABCD1 de novo mutations and mosaicism. Mol Genet Metab. 2011;104(1–2):160–6. doi: 10.1016/j.ymgme.2011.05.016
  8. Polgreen LE, Chahla S, Miller W, Rothman S, Tolar J, Kivisto T, et al. Early diagnosis of cerebral X-linked adrenoleukodystrophy in boys with Addison’s disease improves survival and neurological outcomes. Eur J Pediatr. 2011;170(8):1049–54. doi: 10.1007/s00431-011-1401-1
  9. Assies J, Gooren LJ, Van Geel B, Barth PG. Signs of testicular insufficiency in adrenomyeloneuropathy and neurologically asymptomatic X-linked adrenoleukodystrophy: a retrospective study. Int J Androl. 1997;20(5):315–21. doi: 10.1046/j.1365-2605.1997.00066.x
  10. Aversa A, Palleschi S, Cruccu G, Silvestroni L, Isidori A, Fabbri A. Rapid decline of fertility in a case of adrenoleukodystrophy. Hum Reprod. 1998;13(9):2474–9. doi: 10.1093/humrep/13.9.2474
  11. López-Erauskin J, Fourcade S, Galino J, Ruiz M, Schlüter A, Naudi A, et al. Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy. Ann Neurol. 2011;70(1):84–92. doi: 10.1002/ana.22363
  12. Jaeken J. Congenital disorders of glycosylation (CDG): it’s (nearly) all in it! J Inherit Metab Dis. 2011;34(4):853–8. doi: 10.1007/s10545-011-9299-3
  13. de Zegher F, Jaeken J. Endocrinology of the carbohydrate-deficient glycoprotein syndrome type 1 from birth through adolescence. Pediatr Res. 1995;37(4 Pt 1):395–401. doi: 10.1203/00006450-199504000-00003
  14. Kristiansson B, Stibler H, Wide L. Gonadal function and glycoprotein hormones in the carbohydrate-deficient glycoprotein (CDG) syndrome. Acta Paediatr. 1995;84(6):655–9. doi: 10.1111/j.1651- 2227.1995.tb13720.x
  15. Miller BS, Freeze HH, Hofmann GF, Sarafoglou K. Pubertal development in ALG6 deficiency (congenital disorder of glycosylation type Ic). Mol Genet Metab. 2011;103(1):101–3. doi: 10.1016/j.ymgme.2011.01.016
  16. Shanti B, Silink M, Bhattacharya K, Howard NJ, Carpenter K, Fietz M, et al. Congenital disorder of glycosylation type Ia: heterogeneity in the clinical presentation from multivisceral failure to hyperinsulinaemic hypoglycaemia as leading symptoms in three infants with phosphomannomutase deficiency. J Inherit Metab Dis. 2009;32(Suppl 1):S241–51. doi: 10.1007/s10545-009-1180-2
  17. Chang IJ, He M, Lam CT. Congenital disorders of glycosylation. Ann Transl Med. 2018;6(24):477. doi: 10.21037/atm.2018.10.45
  18. Rubio-Gozalbo ME, Gubbels CS, Bakker JA, Menheere PP, Wodzig WK, Land JA. Gonadal function in male and female patients with classic galactosemia. Hum Reprod Update. 2010;16(2):177–88. doi: 10.1093/humupd/dmp038
  19. Rubio-Gozalbo ME, Haskovic M, Bosch AM, Burnyte B, Coelho AI, Cassiman D, et al. The natural history of classic galacto-semia: lessons from the GalNet registry. Orphanet J Rare Dis. 2019;14(1):86. doi: 10.1186/s13023-019-1047-z
  20. Demirbas D, Coelho AI, Rubio-Gozalbo ME, Berry GT. Hereditary galactosemia. Metabolism. 2018;83:188–96. doi: 10.1016/j. metabol.2018.01.025
  21. Colhoun HO, Rubio Gozalbo EM, Bosch AM, Knerr I, Dawson C, Brady J, et al. Fertility in classical galactosaemia, a study of N-glycan, hormonal and inflammatory gene interactions. Orphanet J Rare Dis. 2018;13(1):164. doi: 10.1186/s13023-018-0906-3
  22. Thakur M, Feldman G, Puscheck EE. Primary ovarian insufficiency in classic galactosemia: current understanding and future research opportunities. J Assist Reprod Genet. 2018;35(1):3–16. doi: 10.1007/s10815-017-1039-7
  23. Fridovich-Keil J, Walter J. Galactosaemia. In: Valle D, editor. The online metabolic and molecular bases of inherited disease, OM-MBID. New York, New York, USA: The McGrawHill Companies, Inc; 2008.
  24. Gubbels CS, Welt CK, Dumoulin JC, Robben SG, Gordon CM, Dunselman GA, et al. The male reproductive system in classic galactosemia: cryptorchidism and low semen volume. J Inherit Metab Dis. 2013;36(5):779–86. doi: 10.1007/s10545-012-9539-1
  25. Kelley RI, Hennekam RC. The Smith-Lemli-opitz syndrome. J Med Genet. 2000;37(5):321–35. doi: 10.1136/jmg.37.5.321.
  26. Wasserstein MP, Larkin AE, Glass RB, Schuchman EH, Desnick RJ, McGovern MM. Growth restriction in children with type B Niemann-Pick disease. J Pediatr. 2003;142(4):424–8. doi: 10.1067/mpd.2003.113
  27. Winkler L, Offner G, Krull F, Brodehl J. Growth and pubertal development in nephropathic cystinosis. Eur J Pediatr. 1993;152(3):244–9. doi: 10.1007/BF01956154
  28. Sansanwal P, Li L, Hsieh SC, Sarwal MM. Insights into novel cellular injury mechanisms by gene expression profiling in nephropathic cystinosis. J Inherit Metab Dis. 2010;33(6):775–86. doi: 10.1007/s10545-010-9203-6
  29. Elmonem MA, Veys KR, Soliman NA, van Dyck M, van den Heuvel LP, Levtchenko E. Cystinosis: a review. Orphanet J Rare Dis. 2016;11:47. doi: 10.1186/s13023-016-0426-y
  30. Besouw MT, Kremer JA, Janssen MC, Levtchenko EN. Fertility status in male cystinosis patients treated with cysteamine. Fertil Steril. 2010;93(6):1880–3. doi: 10.1016/j.fertnstert.2008.12.113
  31. Reiss RE, Kuwabara T, Smith ML, Gahl WA. Successful pregnancy despite placental cystine crystals in a woman with nephropathic cystinosis. N Engl J Med. 1988;319(4):223–6. doi: 10.1056/NEJM198807283190406
  32. Faggiano A, Pisani A, Milone F, Gaccione M, Filippella M, Santoro A, et al. Endocrine dysfunction in patients with Fabry disease. J Clin Endocrinol Metab. 2006;91(11):4319–25. doi: 10.1210/jc.2006-0858
  33. Lacombe D, Germain DP, Papaxanthos-Roche A. Azoospermie: un nouveau signe d’appel de la maladie de Fabry [Azoospermia as a new feature of Fabry disease]. Rev Med Interne. 2010;31(Suppl 2):S214–6. French. doi: 10.1016/S0248-8663(10)70014-X
  34. Amicus Therapeutics. Galafold™ (migalastat) capsules, for oral use: US prescribing information; 2018. Available from: https://www.fda.gov/ Accessed 29 Nov 2019.
  35. Chow J, Rahman J, Achermann JC, Dattani MT, Rahman S. Mitochondrial disease and endocrine dysfunction. Nat Rev Endocrinol. 2017;13(2):92–104. doi: 10.1038/nrendo.2016.151
  36. Pierce SB, Chisholm KM, Lynch ED, Lee MK, Walsh T, Opitz JM, et al. Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome. Proc Natl Acad Sci USA. 2011;108(16):6543–8. doi: 10.1073/pnas.1103471108
  37. Gironi M, Lamperti C, Nemni R, Moggio M, Comi G, Guerini FR, et al. Late-onset cerebellar ataxia with hypogonadism and muscle coenzyme Q10 deficiency. Neurology. 2004;62(5):818–20. doi: 10.1212/01.wnl.0000113719.67643.b7
  38. Carod-Artal FJ, Herrero MD, Lara MC, López-Gallardo E, Ruiz-Pesini E, Martí R, et al. Cognitive dysfunction and hypogonadotrophic hypogonadism in a Brazilian patient with mitochondrial neurogastrointestinal encephalomyopathy and a novel ECGF1 mutation. Eur J Neurol. 2007;14(5):581–5. doi: 10.1111/j.1468-1331.2007.01720.x
  39. Harvey JN, Barnett D. Endocrine dysfunction in Kearns-Sayre syndrome. Clin Endocrinol (Oxf). 1992;37(1):97–103. doi: 10.1111/j.1365-2265.1992.tb02289.x
  40. Rangwala SM, Wang X, Calvo JA, Lindsley L, Zhang Y, Deyneko G, et al. Estrogen-related receptor gamma is a key regulator of muscle mitochondrial activity and oxidative capacity. J Biol Chem. 2010;285(29):22619–29. doi: 10.1074/jbc.M110.125401
  41. Lee PJ, Patel A, Hindmarsh PC, Mowat AP, Leonard JV. The prevalence of polycystic ovaries in the hepatic glycogen storage diseases: its association with hyperinsulinism. Clin Endocrinol (Oxf). 1995;42(6):601–6. doi: 10.1111/j.1365-2265.1995.tb02686.x.
  42. Sechi A, Deroma L, Lapolla A, Paci S, Melis D, Burlina A, et al. Fertility and pregnancy in women affected by glycogen storage disease type I, results of a multicenter Italian study. J Inherit Metab Dis. 2013;36(1):83–9. doi: 10.1007/s10545-012-9490-1
  43. Panis B, Gerver WJ, Rubio-Gozalbo ME. Growth in treated classical galactosemia patients. Eur J Pediatr. 2007;166(5):443–6. doi: 10.1007/s00431-006-0255-4
  44. Polgreen LE, Miller BS. Growth patterns and the use of growth hormone in the mucopolysaccharidoses. J Pediatr Rehabil Med. 2010;3(1):25–38. doi: 10.3233/PRM-2010-0106
  45. Strisciuglio P, Di Maio S, Parenti G, Franzese A, Lubrano P, Mariano A, et al. Evidence of polyglandular involvement in Niemann-Pick disease type B. Eur J Pediatr. 1987;146(4):431–3. doi: 10.1007/BF00444957
  46. Cox NR, Morrison NE, Sartin JL, Buonomo FC, Steele B, Baker HJ. Alterations in the growth hormone/insulin-like growth factor I pathways in feline GM1 gangliosidosis. Endocrinology. 1999;140(12):5698–704. doi: 10.1210/endo.140.12.7178
  47. Kaushansky A, Frydman M, Kaufman H, Homburg R. Endocrine studies of the ovulatory disturbances in Wilson’s disease (hepatolenticular degeneration). Fertil Steril. 1987;47(2):270–3. doi: 10.1016/s0015-0282(16)50004-1
  48. Tan EY, Boelens JJ, Jones SA, Wynn RF. Hematopoietic stem cell transplantation in inborn errors of metabolism. Front Pediatr. 2019;7:433. doi: 10.3389/fped.2019.00433
  49. Todkar K, Ilamathi HS, Germain M. Mitochondria and lysosomes: discovering bonds. Front Cell Dev Biol. 2017;5:106. doi: 10.3389/fcell.2017.00106
  50. Bartelink IH, van Reij EM, Gerhardt CE, van Maarseveen EM, de Wildt A, Versluys B, et al. Fludarabine and exposure-targeted busulfan compares favorably with busulfan/cyclophosphamide-based regimens in pediatric hematopoietic cell transplantation: maintaining efficacy with less toxicity. Biol Blood Marrow Transplant. 2014;20(3):345–53. doi: 10.1016/j.bbmt.2013.11.027
  51. Al-Gadi IS, Haas RH, Falk MJ, Goldstein A, McCormack SE. Endocrine disorders in primary mitochondrial disease. J Endocr Soc. 2018;2(4):361–73. doi: 10.1210/js.2017-00434
  52. Melis D, Pivonello R, Parenti G, Della Casa R, Salerno M, Lombardi G, et al. Increased prevalence of thyroid autoimmunity and hypothyroidism in patients with glycogen storage disease type I. J Pediatr. 2007;150(3):300–5, 305.e1. doi: 10.1016/j. jpeds.2006.11.056
  53. Ön ŞŞ, Acar S, Demir K, Abacı A, Öztürk Y, Kahveci Çelik S, et al. Evaluation of thyroid function tests in children with chronic liver diseases. J Clin Res Pediatr Endocrinol. 2020;12(2):143–9. doi: 10.4274/jcrpe.galenos.2019.2019.0029
  54. Liang WC, Nishino I. State of the art in muscle lipid diseases. Acta Myol. 2010;29(2):351–6.
  55. Benelli E, Fiore E, Giustarini E, Romani R, Pennisi E, Pinchera A, et al. Clear cells detection in nodular thyroid disease is not always indicative of neoplasia: description of the first case of thyroid involvement in multisystem triglyceride storage disease. Thyroid. 2008;18(9):1001–3. doi: 10.1089/thy.2007.0228
  56. Laforêt P, Stojkovic T, Bassez G, Carlier PG, Clément K, Wahbi K, et al. Neutral lipid storage disease with myopathy: a whole-body nuclear MRI and metabolic study. Mol Genet Metab. 2013;108(2):125–31. doi: 10.1016/j.ymgme.2012.12.004
  57. Mohamed M, Theodore M, Claahsen-van der Grinten H, van Herwaarden AE, Huijben K, van Dongen L, et al. Thyroid function in PMM2-CDG: diagnostic approach and proposed management. Mol Genet Metab. 2012;105(4):681–3. doi: 10.1016/j. ymgme.2012.02.001
  58. Gaide Chevronnay HP, Janssens V, Van Der Smissen P, Rocca CJ, Liao XH, Refetoff S, et al. Hematopoietic stem cells transplantation can normalize thyroid function in a cystinosis mouse model. Endocrinology. 2016;157(4):1363–71. doi: 10.1210/en.2015-1762
  59. Weinhofer I, Kunze M, Forss-Petter S, Berger J. Involvement of human peroxisomes in biosynthesis and signaling of steroid and peptide hormones. Subcell Biochem. 2013;69:101–10. doi: 10.1007/978-94-007-6889-5_6
  60. Bruno C, Minetti C, Tang Y, Magalhães PJ, Santorelli FM, Shanske S, et al. Primary adrenal insufficiency in a child with a mitochondrial DNA deletion. J Inherit Metab Dis. 1998;21(2):155–61. doi: 10.1023/a:1005347826664
  61. Boles RG, Roe T, Senadheera D, Mahnovski V, Wong LJ. Mitochondrial DNA deletion with Kearns Sayre syndrome in a child with Addison disease. Eur J Pediatr. 1998;157(8):643–7. doi: 10.1007/s004310050902
  62. Hopkins SE, Somoza A, Gilbert DL. Rare autosomal dominant POLG1 mutation in a family with metabolic strokes, posterior column spinal degeneration, and multi-endocrine disease. J Child Neurol. 2010;25(6):752–6. doi: 10.1177/0883073809343313
  63. Shimizu J, Inatsu A, Oshima S, Shimizu E, Hirata H, Yasuda H, et al. Hyperkalemia in familial mitochondrial cytopathy. Clin Nephrol. 2008;70(4):348–53. doi: 10.5414/cnp70348
  64. Watts RW, Harkness RA, Spellacy E, Taylor NF. Lesch-Nyhan syndrome: growth delay, testicular atrophy and a partial failure of the 11 beta-hydroxylation of steroids. J Inherit Metab Dis. 1987;10(3):210–23. doi: 10.1007/BF01800063
  65. Bianconi SE, Conley SK, Keil MF, Sinaii N, Rother KI, Porter FD, et al. Adrenal function in Smith-Lemli-Opitz syndrome. Am J Med Genet A. 2011 ;155A(11):2732–8. doi: 10.1002/ajmg.a.34271
  66. Donoghue SE, Pitt JJ, Boneh A, White SM. Smith-Lemli-Opitz syndrome: clinical and biochemical correlates. J Pediatr Endocrinol Metab. 2018;31(4):451–9. doi: 10.1515/jpem-2017-0501
  67. Saudubray JM, Sedel F. Les maladies héréditaires du métabolisme à l’âge adulte [Inborn errors of metabolism in adults]. Ann Endocrinol (Paris). 2009;70(1):14–24. French. doi: 10.1016/j.ando.2008.12.004
  68. Erdem E, Cayonu N, Uysalol E, Yildirmak ZY. Chronic intermittent form of isovaleric acidemia mimicking diabetic ketoacidosis. J Pediatr Endocrinol Metab. 2010;23(5):503–5. doi: 10.1515/jpem.2010.082
  69. Marquard J, El Scheich T, Klee D, Schmitt M, Meissner T, Mayatepek E, et al. Chronic pancreatitis in branched-chain organic acidurias – a case of methylmalonic aciduria and an overview of the literature. Eur J Pediatr. 2011;170(2):241–5. doi: 10.1007/s00431-010-1313-5
  70. Vantyghem MC, Fajardy I, Dhondt F, Girardot C, D’Herbomez M, Danze PM, et al. Phenotype and HFE genotype in a population with abnormal iron markers recruited from an Endocrinology Department. Eur J Endocrinol. 2006;154(6):835–41. doi: 10.1530/eje.1.02152
  71. Ogimoto M, Anzai K, Takenoshita H, Kogawa K, Akehi Y, Yoshida R, et al. Criteria for early identification of aceruloplasminemia. Intern Med. 2011;50(13):1415–8. doi: 10.2169/internalmedicine.50.5108
  72. Oki Y, Okubo M, Tanaka S, Nakanishi K, Kobayashi T, Murase T. Diabetes mellitus secondary to glycogen storage disease type III. Diabet Med. 2000;17(11):810–2. doi: 10.1046/j.1464-5491.2000.00378.x
  73. Ismail H. Glycogen storage disease type III presenting with secondary diabetes and managed with insulin: a case report. Cases J. 2009;2:6891. doi: 10.4076/1757-1627-2-6891
  74. Filler G, Amendt P, von Bredow MA, Rohde W, Ehrich JH. Slowly deteriorating insulin secretion and C-peptide production characterizes diabetes mellitus in infantile cystinosis. Eur J Pediatr. 1998;157(9):738–42. doi: 10.1007/s004310050926
  75. Karicheva OZ, Kolesnikova OA, Schirtz T, Vysokikh MY, Mager-Heckel AM, Lombès A, et al. Correction of the consequences of mitochondrial 3243A>G mutation in the MT-TL1 gene causing the MELAS syndrome by tRNA import into mitochondria. Nucleic Acids Res. 2011;39(18):8173–86. doi: 10.1093/nar/gkr546
  76. Karaa A, Goldstein A. The spectrum of clinical presentation, diagnosis, and management of mitochondrial forms of diabetes. Pediatr Diabetes. 2015;16(1):1–9. doi: 10.1111/pedi.12223
  77. Laloi-Michelin M, Meas T, Ambonville C, Bellanné-Chantelot C, Beaufils S, Massin P, et al.; Mitochondrial diabetes French Study Group. The clinical variability of maternally inherited diabetes and deafness is associated with the degree of heteroplasmy in blood leukocytes. J Clin Endocrinol Metab. 2009;94(8):3025–30. doi: 10.1210/jc.2008-2680
  78. Lightfoot YL, Chen J, Mathews CE. Role of the mitochondria in immune-mediated apoptotic death of the human pancreatic β cell line βLox5. PLoS One. 2011;6(6):e20617. doi: 10.1371/journal. pone.0020617
  79. Lindroos MM, Majamaa K, Tura A, Mari A, Kalliokoski KK, Taittonen MT, et al. m.3243A>G mutation in mitochondrial DNA leads to decreased insulin sensitivity in skeletal muscle and to progressive beta-cell dysfunction. Diabetes. 2009;58(3):543–9. doi: 10.2337/db08-0981
  80. Moravej H, Altassan R, Jaeken J, Enns GM, Ellaway C, Balasubramaniam S, et al. Hypoglycemia in CDG patients due to PMM2 mutations: follow up on hyperinsulinemic patients. JIMD Rep. 2019;51(1):76–81. doi: 10.1002/jmd2.12085
  81. de Lonlay P, Seta N. The clinical spectrum of phosphomannose isomerase deficiency, with an evaluation of mannose treatment for CDG-Ib. Biochim Biophys Acta. 2009;1792(9):841–3. doi:10.1016/j.bbadis.2008.11.012
  82. Zeevaert R, Scalais E, Muino Mosquera L, De Meirleir L, De Beaufort C, Witsch M, et al. PGM1 deficiency diagnosed during an endocrine work-up of low IGF-1 mediated growth failure. Acta Clin Belg. 2016;71(6):435–7. doi: 10.1080/17843286.2016.1142043
  83. Marshall JD, Bronson RT, Collin GB, Nordstrom AD, Maffei P, Paisey RB, et al. New Alström syndrome phenotypes based on the evaluation of 182 cases. Arch Intern Med. 2005;165(6):675–83. doi: 10.1001/archinte.165.6.675
  84. Tyni T, Rapola J, Palotie A, Pihko H. Hypoparathyroidism in a patient with long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency caused by the G1528C mutation. J Pediatr. 1997;131(5):766–8. doi: 10.1016/s0022-3476(97)70111-2.
  85. Baruteau J, Levade T, Redonnet-Vernhet I, Mesli S, Bloom MC, Broué P. Hypoketotic hypoglycemia with myolysis and hypoparathyroidism: an unusual association in medium chain acyl-CoA desydrogenase deficiency (MCADD). J Pediatr Endocrinol Metab. 2009;22(12):1175–7. doi: 10.1515/jpem.2009.22.12.1175
  86. Gordon RJ, Levine MA. Genetic disorders of parathyroid development and function. Endocrinol Metab Clin North Am. 2018;47(4):809–23. doi: 10.1016/j.ecl.2018.07.007
  87. Thoene JG. A review of the role of enhanced apoptosis in the pathophysiology of cystinosis. Mol Genet Metab. 2007;92(4):292–8. doi: 10.1016/j.ymgme.2007.07.008
  88. Baig NA, Herrine SK, Rubin R. Liver disease and diabetes mellitus. Clin Lab Med. 2001;21(1):193–207.
  89. Karagiannis A, Harsoulis F. Gonadal dysfunction in systemic diseases. Eur J Endocrinol. 2005;152(4):501–13. doi: 10.1530/eje.1.01886
DOI: https://doi.org/10.34763/jmotherandchild.20202402si.2018.000005 | Journal eISSN: 2719-535X | Journal ISSN: 2719-6488
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Published on: Nov 10, 2020
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