Do drugs used in obstetric anesthesia interfere with early breastfeeding? Characteristics of the pharmacodynamic and pharmacokinetic properties of certain drugs. Part 2

Wilińska, Maria; Walas, Wojciech; Kamińska, Ewa; Malec Milewska, Małgorzata; Sękowska, Agnieszka; Stankiewicz, Joanna; Helwich, Ewa

doi:10.34763/devperiodmed.20192304.233244

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Do drugs used in obstetric anesthesia interfere with early breastfeeding? Characteristics of the pharmacodynamic and pharmacokinetic properties of certain drugs. Part 2

Journal of Mother and Child

Volume 23 (2019): Issue 4 (December 2019)

By: Maria Wilińska , Wojciech Walas, Ewa Kamińska , Małgorzata Malec Milewska , Agnieszka Sękowska , Joanna Stankiewicz and Ewa Helwich

Open Access

|Jan 2021

Figures & Tables

Summary of the pharmacologic characteristics of analgesics [2]_ Tabela I_ Podsumowanie właściwości farmakologicznych leków przeciwbólowych [2]_

Medication Lek	t_0,5 [h]	PHL [h]	t_max	MW [g/mol]	Vd [L/kg]	M/P	EPB [%]	BA oral [%]	pKa	RID [%]
Paracetamol	1-3	1-3	10-60 minutes	151	0.8-1.0	0.91-1.42	10-25	>85	9.5	6.41-24.23
Nalbufine	5	0.86	2-15 minutes (IV, IM)	357	2.4-7.3	1.2	50	16	8.71 9.96	0.5-0.8
Ibuprofen	1.8-2.5		1-2 h	206	0.14		>99	80	4.4	0.1-0.7

Summary of pharmacologic characteristics of local anesthetics [2]_ Tabela II_ Podsumowanie właściwości farmakologicznych leków miejscowo znieczulających [2]_

Medication Lek	t[0h,5]	PHL [h]	t_max	MW [g/mol]	V. [L/kg]	M/P	EPB [%]	BA oral [%]	pKa	RID [%]
0.5% Bupivacaine 0,5% bupiwakaina	2.7	8.1	30-45 minutes	288	0.4-1.0	0.37	95		8.1	0.85-2.92
2% Lidocaine 2% lidokaina	1.8	3	Immediately (IM, IV) natychmiast (IM, IV)	234	1.3	0.4	70	<35	7.9	0.5-3.1

DOI: https://doi.org/10.34763/devperiodmed.20192304.233244 | Journal eISSN: 2719-535X | Journal ISSN: 2719-6488

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Language: English

Page range: 233 - 244

Submitted on: Sep 17, 2019

Accepted on: Nov 12, 2019

Published on: Jan 29, 2021

Published by: Institute of Mother and Child

In partnership with: Paradigm Publishing Services

Publication frequency: 1 issue per year

Keywords:

cesarean section,

hypnotic drugs,

volatile anesthetics,

Related subjects:

Pediatrics and juvenile medicine,

Paediatric haematology and oncology,

Public health

© 2021 Maria Wilińska, Wojciech Walas, Ewa Kamińska, Małgorzata Malec Milewska, Agnieszka Sękowska, Joanna Stankiewicz, Ewa Helwich, published by Institute of Mother and Child
This work is licensed under the Creative Commons Attribution 4.0 License.

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