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Pneumocystis Pneumonia: Still a serious disease in children Cover

Pneumocystis Pneumonia: Still a serious disease in children

Journal of Mother and Child
Volume 23 (2019): Issue 3 (September 2019)
By: Magdalena Zakrzewska,  Renata Roszkowska,  Mateusz Zakrzewski and  Elżbieta Maciorkowska  
Open Access
|Oct 2019

Figures & Tables

Fig. 1

Principal interactions between Pneumocystis jirovecii and the respiratory tract epithelium and immune cells. DC, Dendritic cells; B-glR, β-glucan receptors; GpA, Major surface glycoprotein; IFN-gamma, interferon gamma; IL-6, interleukin 6; IL-8, interleukin 8; MCP-1, Monocyte chemoattractant protein 1; MIP -2, macrophage inflammatory protein 2; MMP-9, Matrix metalloproteinase 9; MR , Mannose receptor; NO, Nitric oxide; NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells; ROS, Reactive oxygen species; SP-B and SP-C, Surfactant proteins B and C; TLR, toll-like receptor; TNF-alpha, tumor necrosis factor alpha. Adapted from [21].
Principal interactions between Pneumocystis jirovecii and the respiratory tract epithelium and immune cells. DC, Dendritic cells; B-glR, β-glucan receptors; GpA, Major surface glycoprotein; IFN-gamma, interferon gamma; IL-6, interleukin 6; IL-8, interleukin 8; MCP-1, Monocyte chemoattractant protein 1; MIP -2, macrophage inflammatory protein 2; MMP-9, Matrix metalloproteinase 9; MR , Mannose receptor; NO, Nitric oxide; NF-κB, Nuclear factor kappa-light-chain-enhancer of activated B cells; ROS, Reactive oxygen species; SP-B and SP-C, Surfactant proteins B and C; TLR, toll-like receptor; TNF-alpha, tumor necrosis factor alpha. Adapted from [21].

Grading of clinical symptoms in Pneumocystis pneumonia_

Disease Exacerbation
Clinical featureMildModerateSevere
DyspneaOn exertionOn minimal exertion/possibly at restAt rest
Oxygen saturationSaO2 > 96%SaO2 of 91–96%SaO2 < 91%
Radiologic findingsMinimal changes on CXRDiffuse interstitial changes on CXRExtensive interstitial changes on CXR
Other---Fever possibleTachypnoea at rest, fever, cough
DOI: https://doi.org/10.34763/devperiodmed.20192303.159162 | Journal eISSN: 2719-535X | Journal ISSN: 2719-6488
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Language: English
Page range: 159 - 162
Submitted on: Aug 13, 2019
|
Accepted on: Aug 27, 2019
|
Published on: Oct 27, 2019
Published by: Institute of Mother and Child
In partnership with: Paradigm Publishing Services
Publication frequency: 1 issue per year
Keywords:
children,
pneumonia,
symptoms,
treatment
Related subjects:
Medicine,
Clinical medicine,
Pediatrics and juvenile medicine,
Paediatric haematology and oncology,
Public health

© 2019 Magdalena Zakrzewska, Renata Roszkowska, Mateusz Zakrzewski, Elżbieta Maciorkowska, published by Institute of Mother and Child
This work is licensed under the Creative Commons Attribution 4.0 License.

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