Univariate analysis of glucose disturbances associated with PVL, n=67_ Tabela VI_ Jednoczynnikowa analiza zależności zaburzeń glikemii i PVL, n=67_
| PVL n=6 | Non – PVL n=61 | p value | |
|---|---|---|---|
| Glucose, median (95% Cl for median) Glukoza, mediana (95% Cl dla mediany) | 6.55 (5.37-7.06) | 5.95 (5.67-6.11) | 0.323t |
| Hypoglycemia <70 mg/dL, median (95% Cl for median) Hipoglikemia <70 mg/dL, mediana (95% Cl dla mediany) | 39.0 (1-107) | 32.0 (21-45) | 0.947mw |
| Hyperglycemia >150 mg/dL, median (95% Cl for median) Hiperglikemia 150 mg/dL, mediana (95% Cl dla mediany) | 158.5 (14-306) | 47 (17-109) | 0.286mw |
| SD of glucose (95% Cl) SD glukozy (95% Cl) | 1.42 (1.01-1.98) | 1.23 (1.12-1.33) | 0.314t |
| CV of glucose (95% Cl) CV glukozy (95% Cl) | 22.54 (17.70-28.69) | 20.37 (19.05-21.79) | 0.369t |
| MAGE (95% Cl) MAGE (95% Cl) | 2.34 (1.81-3.03) | 1.84 (1.72-1.97) | 0.051t |
Univariate analysis of glucose disturbances associated with grade 3 or 4 IVH (severe IVH), n=74_ Tabela IV_ Jednoczynnikowa analiza zależności zaburzeń glikemii i krwawienia dokomorowego stopnia 3 lub 4, n=74_
| Severe IVH Ciężki IVH n=ll | Non–severe IVH Brak ciężkiego IVH n=63 | p value | |
|---|---|---|---|
| Glucose, median (95% Cl for median) Glukoza, mediana (95% Cl dla mediany) | 5.92 (5.45-7.24) | 5.99 (5.68-6.24) | 0.885mw |
| Hypoglycemia <70 mg/dL, median (95% Cl for median) Hipoglikemia <70 mg/dL, mediana (95% Cl dla mediany) | 37 (23.28-123.60) | 32 (21.25-49.24) | 0.273mw |
| Hyperglycemia>150 mg/dL, median (95% Cl for median) Hiperglikemia 150 mg/dL, mediana (95% Cl dla mediany) | 47 (17-341) | 49 (17-118) | 0.697mw |
| SD of glucose (95% Cl) SD glukozy (95% Cl) | 1.55 (1.12-2.16) | 1.23 (1.13-1.34) | 0.052t |
| CV of glucose (95% Cl) CV glukozy (95% Cl) | 25.03 (19.68-31.83) | 20.32 (19.02-21.72) | 0.025t |
| MAGE (95% Cl) MAGE (95% Cl) | 2.27 (1.79-2.88) | 1.85 (1.73-1.98) | 0.032* |
Interstitial fluid glucose concentration and glycemic variability indices in the cohort of very low birth weight infants (n=74)_ Tabela II_ Śródtkankowe stężenie glukozy i wskaźniki zmienności glikemii w kohorcie noworodków z bardzo małą masą ciała (n=74)_
| Parameter Parametr | Value Wartość |
|---|---|
| Glucose, mean (-/+SD) Glukoza, średnia (-/+SD) | 5.96 (0.71) |
| mean, SD (7+SD) średnia, SD (-/+SD) | 1.24 (0.37) |
| CV, geometric mean (+/×GSD) CV, średnia geometryczna (÷/×GSD) | 21.24 (5.58) |
| MAGE, geometric mean (÷/×GSD) MAGE, średnia geometryczna (÷/×GSD) | 1.89 (1.34) |
Univariate analysis of glucose disturbances associated with ROP requiring treatment, n=67_ Tabela V_ Jednoczynnikowa analiza zależności zaburzeń glikemii i ROP wymagającej leczenia, n=67_
| ROP n=22 | Non – ROP n=45 | P value | |
|---|---|---|---|
| Glucose, median (95% Cl for median) Glukoza, mediana (95% Cl dla mediany) | 6.15 (5.96-6.68) | 5.81 (5.49-6.10) | 0.071mw |
| Hypoglycemia <70 mg/dL, median (95% Cl for median) Hipoglikemia <70 mg/dL, mediana (95% Cl dla mediany) | 32 (11.95-75.28) | 32 (20.46=54.23) | 0.898mw |
| Hyperglycemia >150 mg/dL, median (95% Cl for median) Hiperglikemia 150 mg/dL, mediana (95% Cl dla mediany) | 131 (58.81-266.9) | 24 (10.92-71.11) | 0.018mw |
| SD of glucose (95% Cl) SD glukozy (95% Cl) | 1.42 (1.22-1.66) | 1.16 (1.06-1.27) | 0.019t |
| CV of glucose (95% Cl) CV glukozy (95% Cl) | 22.73 (20.06-25.76) | 19.57 (18.23-21.02) | 0.026t |
| MAGE (95% Cl) MAGE (95% Cl) | 2.08 (1.87-2.33) | 1.79 (1.65-1.94) | 0.029t |
Univariate analysis of glucose disturbances associated with death, n=74_ Tabela III_ Jednoczynnikowa analiza zależności zaburzeń glikemii i zgonu, n=74_
| Death Zgony n=7 | Survivors Przeżycie n=67 | p value wartość p | |
|---|---|---|---|
| Glucose, median (95% Cl for median) Glukoza, mediana (95% Cl dla mediany) | 6.01 (5.37-8.48) | 5.95 (5.67-6.19) | 0.548mw |
| Hypoglycemia <70 mg/dL, median (95% Cl for median) Hipoglikemia <70 mg/dL, mediana (95% Cl dla mediany) | 75 (22-172) | 32 (22-44) | 0.202mw |
| Hyperglycemia >150 mg/dL, median (95% Cl for median) Hiperglikemia 150 mg/dL, mediana (95% Cl dla mediany) | 119 (0.0-508) | 47 (20-112) | 0.664mw |
| SD of glucose (95% Cl) SD glukozy (95% Cl) | 1.68 (0.97-2.93) | 1.23 (1.14-1.34) | 0.226w |
| CV of glucose (95% Cl) CV glukozy (95% Cl) | 26.15 (17.31-39.51) | 20.43 (19.28-21.82) | 0.205w |
| MAGE (95% Cl) MAGE (95% Cl) | 2.28 (1.49-3.47) | 1.87 (1.75-1.99) | 0.295” |
Multivariate linear regression model_ Tabela VII_ Wieloczynnikowa regresja logistyczna_
| Zmienne Variables modelu | B | Wald X2 | P | OR (95% Cl) |
|---|---|---|---|---|
| ROP requiring treatment | -0.01 | 6.53 | 0.011 | 0.98 (0.97-0.99) |
| Hosmer-Lemeshow test 0.179 | ||||
| Severe IVH | -0.54 | 6.11 | 0.04 | (0.38-0.87) |
| Hosmer-Lemeshow test 0.127 | ||||
Demographic and clinical characteristics of the patients_ Tabela I_ Charakterystyka kliniczna i demograficzna pacjentów_
| Number of patients Liczba pacjentów | 74 |
|---|---|
| Birth weight, g, mean (SD) Masa urodzeniowa, g, średnia (SD) | 1066 (267) |
| Gender, male n (%) Płeć męska, n (%) | 44 (59.5) |
| GA, wk median (IQR) Wiek płodowy, tyg., mediana (IQR) | 28 (26-30) |
| CRIB II score, median (IQR) Skala CRIB II, mediana (IQR) | 7(5-10) |
| Small for GA, n (%) Mały do wieku płodowego, n (%) | 6(8.1) |
| Antenatal steroids, n (%) Steroidy prenatalnie, n (%) | 47 (62.6) |
| Death before 7 DOL, n (%) Zgon przed 7 dobą życia, n (%) | 3 (4.0) |
| Death before term-equivalent age, n (%) Zgon przed osiągnięciem wieku skorygowanego, n (%) | 7(9.5) |