Fig. 1
Derivatives resulting from the selective decomposition of chromogranin A (CgA) into particular fragments and their major functions and roles_ Adapted from [8] and [9]_ PTH - parathormone, DCG - Dense-core secretory granule, nAchR - nicotinic acetylcholine receptor_
| Protein/peptide (abbreviation) | Amino acid sequence in CgA | Principal functions/properties ascribed |
|---|---|---|
| CgA | 1-439 | DCG biogenesis and hormones sequestration at the Golgi level |
| Vasostatin I (VST I) | 1-76 | vasodilating, antiadrenergic, antiangiogenic, and proapoptotic properties; inhibits PTH secretion, promotes cell adhesion; inhibits endothelial cell proliferation/migration; antimicrobial properties |
| Vasostatin II (VST II) | 1-115 | antimicrobial, vasodilating |
| Chromacin | 176-197 | antimicrobial (both bacteriolytic and antifungal) |
| Pancreastatin (PST) | 250-301 | inhibits insulin release and glucose uptake, inhibits PTH release, inhibits glycogenolysis, stimulates glucagon and histamine release |
| Catestatin (CST) | 352-372 | inhibits nAchRs and catecholamine release, vasodilating properties; induces endothelial cell proliferation/migration; reduces cardiac contractility |
| Serpinin, or serine protease inhibitor | 402-439 | DCG biogenesis; proadrenergic properties; cell death inhibitor |