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Analysis of Clinical Characteristics and Antimicrobial Resistance in 249 Isolates of Streptococcus mitis: a Single-Centre Study Cover

Analysis of Clinical Characteristics and Antimicrobial Resistance in 249 Isolates of Streptococcus mitis: a Single-Centre Study

Open Access
|Sep 2025

References

  1. Basaranoglu ST, Ozsurekci Y, Aykac K, Aycan AE, Bıcakcigil A, Altun B, Sancak B, Cengiz AB, Kara A, Ceyhan M. Streptococcus mitis/oralis causing blood stream infections in pediatric patients. Jpn J Infect Dis. 2019;72(1):1–6. https://doi.org/10.7883/yoken. JJID.2018.074
  2. CLSI. Performance standards for antimicrobial susceptibility testing. 32rd ed. CLSI supplement M100. Wayne (USA): Clinical and Laboratory Standards Institute; 2022.
  3. De Paolis F, Beghetto E, Spadoni A, Montagnani F, Felici F, Oggioni MR, Gargano N. Identification of a human immunodominant B-cell epitope within the immunoglobulin A1 protease of Streptococcus pneumoniae. BMC Microbiol. 2007;7:113. https://doi.org/10.1186/1471-2180-7-113
  4. Denapaite D, Brückner R, Nuhn M, Reichmann P, Henrich B, Maurer P, Schähle Y, Selbmann P, Zimmermann W, Wambutt R, et al. The genome of Streptococcus mitis B6 – What is a commensal? PLoS One. 2010;5(2):e9426. https://doi.org/10.1371/journal. pone.0009426
  5. Dinani A, Ktaich N, Urban C, Rubin D. Levofloxacin-resistant-Streptococcus mitis endophthalmitis: a unique presentation of bacterial endocarditis. J Med Microbiol. 2009;58(Pt 10):1385– 1387. https://doi.org/10.1099/jmm.0.012658-0
  6. Ergin A, Eser ÖK, Hasçelik G. Erythromycin and penicillin resistance mechanisms among viridans group streptococci isolated from blood cultures of adult patients with underlying diseases. New Microbiol. 2011;34(2):187–193.
  7. Fukayama H, Shoji K, Yoshida M, Iijima H, Maekawa T, Ishiguro A, Miyairi I. Bacterial meningitis due to the Streptococcus mitis group in children with cerebrospinal fluid leak. IDCases. 2022;27:e01406. https://doi.org/10.1016/j.idcr.2022.e01406
  8. Harju I, Lange C, Kostrzewa M, Maier T, Rantakokko-Jalava K, Haanperä M. Improved differentiation of Streptococcus pneumoniae and other S. mitis group streptococci by MALDI Biotyper using an improved MALDI Biotyper database content and a novel result interpretation algorithm. J Clin Microbiol. 2017;55(3):914–922. https://doi.org/10.1128/jcm.01990-16
  9. Imai K, Nemoto R, Kodana M, Tarumoto N, Sakai J, Kawamura T, Ikebuchi K, Mitsutake K, Murakami T, Maesaki S, et al. Rapid and accurate species identification of mitis group streptococci using the MinION Nanopore Sequencer. Front Cell Infect Microbiol. 2020;10:11. https://doi.org/10.3389/fcimb.2020.00011
  10. Kalizang’oma A, Richard D, Kwambana-Adams B, Coelho J, Broughton K, Pichon B, Hopkins KL, Chalker V, Beleza S, Bentley SD, et al. Population genomics of Streptococcus mitis in UK and Ireland bloodstream infection and infective endocarditis cases. Nat Commun. 2024;15(1):7812. https://doi.org/10.1038/s41467- 024-52120-z
  11. Kanjanabuch P, Banjongjit A, Purisinsith S, Towannang P, Kanjanabuch T. Streptococcus mitis peritonitis in a peritoneal dialysis patient: A case report highlighting the importance of dental hygiene. Cureus. 2024;16(7):e64693. https://doi.org/10.7759/cureus.64693
  12. Krcmery V Jr, Spanik S, Trupl J. First report of vancomycin-resistant Streptococcus mitis bacteremia in a leukemic patient after prophylaxis with quinolones and during treatment with vancomycin. J Chemother. 1996;8(4):325–326. https://doi.org/10.1179/joc.1996.8.4.325
  13. Lessa FC, Milucky J, Rouphael NG, Bennett NM, Talbot HK, Harrison LH, Farley MM, Walston J, Pimenta F, Gertz RE, et al. Streptococcus mitis expressing pneumococcal serotype 1 capsule. Sci Rep. 2018;8(1):17959. https://doi.org/10.1038/s41598-018- 35921-3
  14. Marron A, Carratalà J, Alcaide F, Fernández-Sevilla A, Gudiol F. High rates of resistance to cephalosporins among viridans-group streptococci causing bacteraemia in neutropenic cancer patients. J Antimicrob Chemother. 2001;47(1):87–91. https://doi.org/10.1093/jac/47.1.87
  15. Marron A, Carratalà J, González-Barca E, Fernández-Sevilla A, Alcaide F, Gudiol F. Serious complications of bacteremia caused by viridans streptococci in neutropenic patients with cancer. Clin Infect Dis. 2000;31(5):1126-30. https://doi.org/10.1086/317460
  16. Mitchell J. Streptococcus mitis: Walking the line between commensalism and pathogenesis. Mol Oral Microbiol. 2011;26(2):89–98. https://doi.org/10.1111/j.2041-1014.2010.00601.x
  17. Narikiyo M, Tanabe C, Yamada Y, Igaki H, Tachimori Y, Kato H, Muto M, Montesano R, Sakamoto H, Nakajima Y, et al. Frequent and preferential infection of Treponema denticola, Streptococcus mitis, and Streptococcus anginosus in esophageal cancers. Cancer Sci. 2004;95(7):569–574. https://doi.org/10.1111/j.1349-7006.2004.tb02488.x
  18. Nix ID, Idelevich EA, Schlattmann A, Sparbier K, Kostrzewa M, Becker K. MALDI-TOF mass spectrometry-based optochin susceptibility testing for differentiation of Streptococcus pneumoniae from other Streptococcus mitis group streptococci. Microorganisms. 2021;9(10):2010. https://doi.org/10.3390/microorgan-isms9102010
  19. Pan F, Zhao N, Zhao W, Wang C, Sun Y, Zhang H, Qin J, Liu Q, Zhang H. Performance of two matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) systems for identification of the viridans group streptococci. Infect Drug Resist. 2023;16:2901–2909. https://doi.org/10.2147/IDR. S407667
  20. Prod’homme M, Grasset D, Chalaron M, Boscherini D. Epidural abscess related to Streptococcus mitis in a 57-year-old immunocompetent patient. BMJ Case Rep. 2021;14(4):e239295. https://doi. org/10.1136/bcr-2020-239295
  21. Rasmussen LH, Højholt K, Dargis R, Christensen JJ, Skovgaard O, Justesen US, Rosenvinge FS, Moser C, Lukjancenko O, Rasmussen S, et al. In silico assessment of virulence factors in strains of Streptococcus oralis and Streptococcus mitis isolated from patients with infective endocarditis. J Med Microbiol. 2017;66(9):1316– 1323. https://doi.org/10.1099/jmm.0.000573
  22. Reilly AF, Lange BJ. Infections with viridans group streptococci in children with cancer. Pediatr Blood Cancer. 2007;49(6):774–780. https://doi.org/10.1002/pbc.21250
  23. Sadowy E, Bojarska A, Kuch A, Skoczyńska A, Jolley KA, Maiden MCJ, van Tonder AJ, Hammerschmidt S, Hryniewicz W. Relationships among streptococci from the mitis group, misidentified as Streptococcus pneumoniae. Eur J Clin Microbiol Infect Dis. 2020;39(10):1865–1878. https://doi.org/10.1007/s10096-020- 03916-6
  24. Shelburne SA, Sahasrabhojane P, Saldana M, Yao H, Su X, Horstmann N, Thompson E, Flores AR. Streptococcus mitis strains causing severe clinical disease in cancer patients. Emerg Infect Dis. 2014;20(5):762–771. https://doi.org/10.3201/eid2005.130953
  25. Talari Sree CS, Calerappa RS, Anke G. Aerobic bacteria study, clinical spectrum, and outcome of patients with community-acquired multidrug-resistant pathogens. J Family Med Prim Care. 2024;13(11):5052–5059. https://doi.org/10.4103/jfmpc. jfmpc_680_24
  26. Thielemans E, Oliver J, McMinn A, Baker C, Britton PN, Clark J, Marshall H, Blyth CC, Francis J, Buttery J, et al. Clinical description and outcomes of Australian children with invasive group A streptococcal disease. Pediatr Infect Dis J. 2020;39(5):379–384. https://doi.org/10.1097/INF.0000000000002596
  27. Tian XY, Zheng N, Han RW, Ho H, Wang J, Wang YT, Wang SQ, Li HG, Liu HW, Yu ZN. Antimicrobial resistance and virulence genes of Streptococcus isolated from dairy cows with mastitis in China. Microb Pathog. 2019;131:33–39. https://doi.org/10.1016/j. micpath.2019.03.035
  28. Tunkel AR, Sepkowitz KA. Infections caused by viridans streptococci in patients with neutropenia. Clin Infect Dis. 2002;34(11):1524–1529. https://doi.org/10.1086/340402
  29. Wan TW, Lee TF, Chen XJ, Hunag YT, Teng LJ, Hsueh PR, Chiu HC. Performance assessment of the Bruker Biotyper MALDI-TOF MS for the identification of difficult-to-identify viridans group streptococci. J Clin Microbiol. 2023;61(12):e0114323. https://doi. org/10.1128/jcm.01143-23
  30. Zhang B, Zhou J, Xie G, Zhang L, Zhang Y, Xu K, Feng T, Yang S. A Case of urinary tract infection caused by multidrug resistant Streptococcus mitis/oralis. Infect Drug Resist. 2023;16:4285–4288. https://doi.org/10.2147/idr.s416387
  31. Zhang Y, Shang L, Roffel S, Spiekstra SW, Deng D, Gibbs S. Streptococcus mitis enhances metal-induced apoptosis in reconstructed human gingiva but not skin. Toxicol In Vitro. 2024;100:105913. https://doi.org/10.1016/j.tiv.2024.105913
  32. Zhou JM, Wu CY, Li JP, Ye YH, Fang C, Zhou MM. Low penicillin susceptibility in Streptococcus mitis/oralis from bloodstream infections in pediatric populations. Microbiol Spectr. 2024;12(11):e0135024. https://doi.org/10.1128/spectrum.01350-24
DOI: https://doi.org/10.33073/pjm-2025-028 | Journal eISSN: 2544-4646 | Journal ISSN: 1733-1331
Language: English
Page range: 329 - 337
Submitted on: May 11, 2025
Accepted on: Aug 1, 2025
Published on: Sep 16, 2025
Published by: Polish Society of Microbiologists
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2025 JINGJING KUAI, JIANWEI JI, LING XIAO, PING WANG, YONGLAN SHAN, DONGMEI YAN, published by Polish Society of Microbiologists
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.