Gut Microbiota, Circulating Metabolites and Risk of Endometriosis: A Two-Step Mendelian Randomization Study

Yang, Hua

doi:10.33073/pjm-2024-041

Figures & Tables

The detailed flowchart of present mendelian randomization analysis.

The forest plot summarized the causality of gut microbiota on the risk of endometriosis.

The forest plot summarized the causality of circulating metabolites on the risk of endometriosis.

The forest plot summarized the causality between circulating metabolites and gut microbiota.

The causality of circulating metabolites on risk of endometriosis_

Exposure	Subset	IVW/Wald ratio			MR Egger			Weighted median			Horizontal pleiotropy			Heterogeneity
Exposure		α	SE	p-value	α	SE	p-value	α	SE	p-value	ERI	SE	p-value	Q	p-value
1-Eicosatrienoylglycero-phosphocholine	lipid	0.7316	0.001575	0.02416	2.538	0.7409	0.006486	0.005782	0.002841	0.04843	–0.048	0.018	0.0253	8.367	0.593
1-Oleoylglycero-phosphocholine	lipid	1.15	0.4893	0.01871	–1.011	1.023	0.3685	1.157	0.652	0.07597	0.043	0.018	0.0658	1.725	0.8858
2-Aminooctanoic acid	amino acid	0.3516	0.1602	0.02819	0.2772	0.262	0.3716	0.3716	0.1729	0.06623	0.004	0.011	0.72	10.64	0.301
3 - Phenylpropionate	amino acid	–0.6252	0.2425	0.009951	–0.4805	0.3796	0.3331	–0.5788	0.2893	0.04539	–0.0095	0.019	0.669	0.7925	0.6729
Decanoylcarnitine	lipid	0.4646	0.1842	0.01166	0.5798	0.3388	0.1307	0.5456	0.2251	0.01536	–0.0055	0.013	0.697	4.314	0.743
Dihomo-linolenate	fatty acid	–0.7076	0.3451	0.04032	0.05512	0.9978	0.9569	–0.4608	0.4847	0.3418	–0.015	0.018	0.43	12.96	0.3723
Dimethylarginine (SDMA + ADMA)	amino acid	–1.255	0.4615	0.006548	–2.798	1.317	0.04693	–2.063	0.6368	0.001197	0.017	0.014	0.226	14.04	0.7814
Ergothioneine	xenobiotics	–1.13	0.4685	0.4685	–	–	–	–	–	–	–	–	–	–	–
Hexadecanedioate	lipid	0.3527	0.128	0.005867	0.3823	0.1914	0.06711	0.4095	0.1608	0.01088	–0.002	0.0095	0.834	17.36	0.1832
Hexanoylcarnitine	lipid	0.4772	0.2379	0.04487	0.4677	0.4768	0.3523	0.4522	0.2656	0.08871	0.00032	0.014	0.982	12.08	0.2089
Octanoylcarnitine	lipid	0.4604	0.2092	0.02779	0.4957	0.3655	0.2466	0.4395	0.2324	0.05855	–0.0017	0.015	0.912	0.3964	0.9828
Palmitate (16:0)	fatty acid	–1.415	0.4277	0.0009344	–2.996	0.9716	0.006741	–0.9829	0.6468	0.1286	0.021	0.011	0.0878	11.85	0.809
Pseudouridine	nucleotide	–1.312	0.6122	0.03213	1.971	2.362	0.4164	–1.942	0.8565	0.02334	–0.035	0.024	0.17	16.41	0.4244
Stearate (18:0)	fatty acid	–0.7386	0.3701	0.04598	–0.1354	–0.1354	0.8967	–0.3944	0.5247	0.4522	–0.007	0.011	0.537	15.77	0.8962
Threonine	amino acid	0.9348	0.4587	0.04153	0.04153	1.501	1.501	0.6212	0.5832	0.2868	0.011	0.022	0.635	8.823	0.6382

The causality of gut microbiota abundance on risk of endometriosis_

Exposure	n SNP	IVW			MR Egger			Weighted median			Horizontal pleiotropy			Heterogeneity
Exposure	n SNP	β	se	p-value	β	se	p-value	β	se	p-value	ERI	se	p-value	Q	p-value
class Negativicutes	7	0.002521	0.001072	0.01863	0.005405	0.003049	0.1364	0.002102	0.001445	0.1458	–0.00022	0.00022	0.359	6.198	0.4014
genus Dialister	2	0.003723	0.001718	0.03027	–	–	–	–	–	–	–	–	–	0.7413	0.3893
genus Enterorhabdus	3	0.002015	0.0009595	0.03575	0.0005135	0.002386	0.8651	0.001771	0.001182	0.134	0.00026	0.00038	0.617	0.7286	0.6947
genus Eubacterium xylanophilum group	7	0.003385	0.000999	0.0007027	–0.001805	–0.001805	0.5773	0.003223	0.001374	0.01897	0.00044	0.00025	0.131	6.42	0.3778
genus Methanobrevibacter	3	0.001948	0.0007719	0.0007719	0.002244	0.003202	0.6108	0.001635	0.001025	0.1107	–0.00005	0.00051	0.938	1.767	0.4134
order Selenomonadales	7	0.002521	0.001072	0.01863	0.005405	0.003049	0.1364	0.1364	0.001445	0.1458	–0.00022	0.00022	0.359	6.198	0.4014
genus Coprococcus 1	7	–0.003294	0.001028	0.001354	–0.001902	0.003123	0.5692	–0.002869	0.001362	0.03517	–0.00011	0.00022	0.657	4.788	0.5713
genus Senegalimassilia	2	–0.003588	0.00158	0.02319	–	–	–	–	–	–	–	–	–	1.34	0.2471

Gut Microbiota, Circulating Metabolites and Risk of Endometriosis: A Two-Step Mendelian Randomization Study

Figures & Tables

Fig. 1.

Fig. 2.

Fig. 3.

Fig. 4.

The causality of circulating metabolites on risk of endometriosis_

The causality of gut microbiota abundance on risk of endometriosis_

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