Fig. 1.
Fig. 2.
Mendelian randomization (MR) analysis of gut microbiota on sepsis at genome-wide significance level (p < 5_0 × 10−8)_
| Classification | Bacterial taxa | Outcome | No. SNP | MR method | Beta | SE | OR | 95% CI | P | F | Horizontal pleiotropy | Heterogeneity |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Actinobacteria | phylum | ieu-b-4980 | 4 | IVW | −0.222 | 0.1 | 0.801 | 0.658–0.975 | 0.027 | 190.05 | 0.47 | 0.76 |
| 4 | Weighted median | −0.245 | 0.116 | 0.783 | 0.623–0.983 | 0.035 | ||||||
| ieu-b-5088 | 4 | IVW | −0.23 | 0.099 | 0.795 | 0.655–0.964 | 0.02 | 190.04 | 0.6 | 0.94 | ||
| 4 | Weighted median | −0.25 | 0.109 | 0.779 | 0.629–0.965 | 0.022 | ||||||
| ieu-b-69 | 4 | IVW | −0.338 | 0.101 | 0.713 | 0.585–0.869 | 0.001 | 190.04 | 0.55 | 0.74 | ||
| 4 | Weighted median | −0.367 | 0.118 | 0.693 | 0.550–0.873 | 0.002 | ||||||
| ieu-b-69 | 6 | IVW | −0.231 | 0.071 | 0.794 | 0.691–0.912 | 0.001 | 352.59 | 0.44 | 0.02 | ||
| 6 | Weighted median | −0.241 | 0.089 | 0.786 | 0.660–0.936 | 0.007 | ||||||
| Bifidobacteriaceae | order | ieu-b-4981 | 7 | IVW | 1.051 | 0.368 | 2.861 | 1.391–5.885 | 0.004 | 390.71 | 0.18 | 0.3 |
| 7 | Weighted median | 1.024 | 0.49 | 2.783 | 1.065–7.276 | 0.037 | ||||||
| ieu-b-69 | 7 | IVW | −0.199 | 0.065 | 0.819 | 0.722–0.930 | 0.002 | 388.52 | 0.55 | 0.74 | ||
| 7 | Weighted median | −0.208 | 0.081 | 0.812 | 0.692–0.952 | 0.01 | ||||||
| ieu-b-69 | 7 | IVW | −0.231 | 0.071 | 0.819 | 0.722–0.930 | 0.001 | 388.52 | 0.55 | 0.74 | ||
| 7 | Weighted median | −0.208 | 0.082 | 0.812 | 0.691–0.954 | 0.012 | ||||||
| ieu-b-69 | 9 | IVW | −0.204 | 0.065 | 0.815 | 0.724–0.912 | 0.002 | 441.31 | 0.83 | 0.9 | ||
| 9 | Weighted median | −0.226 | 0.079 | 0.798 | 0.683–0.931 | 0.004 | ||||||
| Tyzzerella | genus | finn-b-ASTHMA_PNEUMONIA_AND_SEPSIS | 1 | Wald ratio | −0.371 | 0.174 | 0.69 | 0.490–0.970 | 0.033 | – | – | – |
| Gastranaerophilales | order | finn-b-015_PUERP_SEPSIS | 1 | Wald ratio | −0.526 | 0.265 | 0.59 | 0.352–0.992 | 0.047 | – | – | – |
Details of data sources_
| Trait | Population | Sample_size | Case | Control | |
|---|---|---|---|---|---|
| ieu-b-5088 | Sepsis (under 75) | European | 462,869 | 11,568 | 451,301 |
| ieu-b-4980 | Sepsis | European | 486,484 | 11,643 | 474,841 |
| ieu-b-69 | Sepsis | European | 462,918 | 10,154 | 454,764 |
| finn-b-O15_PUERP_SEPSIS | Puerperal sepsis | European | 121,441 | 2,286 | 119,155 |
| finn-b-ASTHMA_PNEUMONIA_AND_SEPSIS | Asthma-related pneumonia or sepsis | European | 140,994 | 5,545 | 135,449 |