Microbiota Diversity in Non-Small Cell Lung Cancer Gut and Mouth Cavity Microbiota Diversity in Non-Small Cell Lung Cancer Patients Cover

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Microbiota Diversity in Non-Small Cell Lung Cancer Gut and Mouth Cavity Microbiota Diversity in Non-Small Cell Lung Cancer Patients

Polish Journal of Microbiology

Volume 72 (2023): Issue 4 (December 2023)

By: Aneta Brisudová, Hana Bielniková-Kryštofová, Oldřich Motyka, Dominika Fritzová, Vladimíra Katuchová, Natálie Ponikelská, Daniela Skanderová, Vladislav Raclavský, Jaroslav Michálek, Marcel Mitták, Petra Švecová, Petr Jakubec, Denisa Rozsivalová, Marek Szkorupa, JIří Klein, Jozef Škarda, Zdeněk Kolář and Valeria Skopelidou

Open Access

|Dec 2023

Figures & Tables

Relative abundance (%) of bacterial species overrepresented ≥ 1.5 ×, or underrepresented ≤ 0.5 ×, in ADC versus SCC patients’ mouth wash. Y axis – number of patients, blue columns – ADC patients, orange columns – SCC patients, * – significant difference (p ≤ 0.05), ADC – adenocarcinoma, SCC – squamous cell carcinoma

Relative abundance (%) of bacterial species overrepresented ≥ 1.5 ×, or underrepresented ≤ 0.5 ×, in ADC versus SCC patients’ rectal swabs. Y axis – number of patients, blue columns – ADC patients, orange columns – SCC patients, * – significant difference (p ≤ 0.05), ADC – adenocarcinoma, SCC – squamous cell carcinoma

Correlation of smoking status and overall survival probability presented using Kaplan-Meier survival curves. N signifies non-smokers, while Y represents smokers.

Characterization of the patient cohort_

		ADC	SCC
Age median		72	70
Male/Female		54/32	39/16
Stage	I	12	13
	II	9	10
	III	23	17
	IV	42	15
Smoker		26	22
Ex-smoker		45	26
Non-smoker		15	7

Comparison of bacterial species cultured from rectal swabs in adenocarcinoma (ADC; n = 85) and squamous cell carcinoma (SCC; n = 52) in NSCLC patients versus patients without confirmed lung cancer (n = 65)_ The species are ranked according to the measure of overrepresentation in ADC versus SCC patients (column 6, ADC/SCC ratio)_ Only those overrepresented ≥ 1,5 × or underrepresented ≤ 0,5 × are listed_

Species	ADC patients		SCC patients		No lung cancer		ADC/SCC ratio	p-value ADC/SCC	p-value ADC/non
Species	n	%	n	%	n	%	ADC/SCC ratio	p-value ADC/SCC	p-value ADC/non
Klebsiella oxytoca	11	12,9	1	1,9	8	12,3	6,8	–	0,688
Streptococcus anginosus	42	49,4	12	22,6	33	50,8	2,2	0,002	0,109
Streptococcus MOPP*	20	23,5	6	11,3	12	18,5	2,1	0,074	0,453
Collinsella aerofaciens	28	32,9	10	18,9	13	20,0	1,7	0,072	0,086
Corynebacterium aurimucosum	12	14,1	15	28,3	19	29,2	0,5	0,041	0,024
Alistipes shahii	2	2,4	5	9,6	2	30,8	0,2	–	–

Comparison of bacterial species cultured from mouth wash in adenocarcinoma (ADC; n = 85) and squamous cell carcinoma (SCC; n = 53) in NSCLC patients versus patients without confirmed lung cancer (n = 65)_ The species are ranked according to the measure of overrepresentation in ADC versus SCC patients (column 6, ADC/SCC ratio)_ Only those overrepresented ≥ 1,5 × or underrepresented ≤ 0,5 × are listed_

Species	ADC patients		SCC patients		No lung cancer		ADC/SCC ratio	p-value ADC/SCC	p-value ADC/non
Species	n	%	n	%	n	%	ADC/SCC ratio	p-value ADC/SCC	p-value ADC/non
Rothia aeria	9	10.5	1	0.2	14	21.5	52.5	–	–
Streptococcus constellatus	13	15.1	3	5.5	16	24.6	2.7	0.080	0.152
Neisseria macacae	21	24.4	6	10.9	13	20.0	2.2	0.047	0.495
Streptococcus mutans	24	27.9	7	12.7	9	13.8	2.2	0.034	0.035
Streptococcus sanguinis	25	29.1	8	14.5	16	24.6	2.0	0.047	0.514
Streptococcus anginosus	46	53.5	19	34.5	23	35.4	1.5	0.028	0.023
Lactobacillus fermentum	9	10.5	17	30.9	14	20.9	0.3	0.002	0.065
Candida tropicalis	2	2.4	11	20.8	1	0.01	0.1	–	–

DOI: https://doi.org/10.33073/pjm-2023-044 | Journal eISSN: 2544-4646 | Journal ISSN: 1733-1331

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Language: English

Page range: 467 - 475

Submitted on: Aug 10, 2023

Accepted on: Oct 27, 2023

Published on: Dec 16, 2023

Published by: Polish Society of Microbiologists

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

oncogenic mutations,

non-small cell lung carcinoma

Related subjects:

Microbiology and virology

© 2023 Aneta Brisudová, Hana Bielniková-Kryštofová, Oldřich Motyka, Dominika Fritzová, Vladimíra Katuchová, Natálie Ponikelská, Daniela Skanderová, Vladislav Raclavský, Jaroslav Michálek, Marcel Mitták, Petra Švecová, Petr Jakubec, Denisa Rozsivalová, Marek Szkorupa, JIří Klein, Jozef Škarda, Zdeněk Kolář, Valeria Skopelidou, published by Polish Society of Microbiologists
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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