Recent Transmission and Prevalent Characterization of the Beijing Family Mycobacterium tuberculosis in Jiangxi, China Cover

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Recent Transmission and Prevalent Characterization of the Beijing Family Mycobacterium tuberculosis in Jiangxi, China

Polish Journal of Microbiology

Volume 71 (2022): Issue 3 (September 2022)

By: Dong Luo, Shengming Yu, Yuyang Huang, Jiahuan Zhan, Qiang Chen, Liang Yan and Kaisen Chen

Open Access

|Sep 2022

Figures & Tables

The MIRU-VNTR genotypes in Jiangxi province, China – the study design. NTM – nontuberculous mycobacteria.

Map of Jiangxi showing the distribution of 1,433 isolates included in this study (the numbers indicate the absolute number of isolates in every region).

Prevalent characterization of Beijing and non-Beijing family strains_

Characteristics	Beijing family				Non-Beijing family
Characteristics	Clustered n = 612	Non-clustered n = 508	OR (95% CI)	p-value	Clustered n = 46	Non-clustered n = 267	OR (95% CI)	p-value
Sex
Men	384	267	–	–	32	177	–	–
Women	228	241	1.210.–512. 93	0 .001	14	90	0.519.–126. 29	0.74
Age
≤ 30	187	176	–	–	13	78	–	–
30–50	232	149	0.501.–608. 91	0 .01	19	67	0.207.5–818.2 8	0.24
≥ 50	193	183	0.716.–011. 34	1 .00	14	122	0.615.–435. 25	0.41
Treatment history
New	530	461	–	–	32	203	–	–
Recurrent	67	38	0.403.–605. 99	0 .05	11	52	0.305.–714. 58	0.42
Treatment failure	15	9	0.300.–619. 59	0 .42	3	14	0.200.–724. 70	0.71
HIV status
Positive	28	23	–	–	2	14	–	–
Negative	584	485	0.518.–011. 78	1 .00	44	253	0.108.–832. 74	1.00
Sputum
Negative	121	104	–	–	12	83	–	–
Positive	391	404	0.819.–210. 62	0 .23	34	184	0.309.–718. 59	0.60
Cavity
No	494	432	–	–	39	225	–	–
Yes	118	76	0.919.–316. 86	0 .07	7	42	0.400.–926. 30	1.00

Demographic and drug-resistant characteristics of this study’s isolates (n = 1,433)_

Characteristics	Number	Beijing family	Non-Beijing family	OR (95% CI)	p-value
All	1,433	1,120	313	–	–
Sex
Men	860	651	209	–	–
Women	57 3	41 9	154	0.910.–114. 46	0.29
Age
≥ 50	512	376	136	–	–
30–50	46 7	38 1	86	1.114.–414. 83	0.003
≤ 30	45 4	36 3	91	1.015.–313. 67	0.02
Treatment history
New	1,174	900	274	–	–
Recurrent	16 8	14 5	23	0.303.–502. 83	0.004
Treatment failure	91	7 5	16	0.400.–710. 22	0.24
Region
Southern regions	249	181	68	–	–
Central regions	72 2	56 7	155	0.502.–713. 01	0.07
Northern regions	46 2	37 2	90	0.405.–604. 92	0.02
DST profile
DST profile	1,433	1,120	313	–	–
Pansusceptible	99 2	79 4	198	0.703.–819. 09	0.27
RIF	2 7	1 8	9	0.810.–749. 02	0.16
INH	3 3	2 5	8	0.511.–124. 56	0.68
SM	5 2	4 4	8	0.300.–615. 40	0.31
EMB	6	5	1	0.008.–762. 15	1.00
AK	1 9	1 5	4	0.301.–925. 90	1.00
CM	1 8	1 3	5	0.419.–338. 89	0.57
LEV	3 8	3 0	8	0.403.–925. 10	1.00
RIF + INH	5 6	4 7	9	0.303.–618. 41	0.41
RIF + SM	2 0	1 5	5	0.413.–139. 31	0.78
INH + SM	4 1	3 4	7	0.302.–714. 68	0.57
RIF + EMB	5	3	2	0.402–.3194 .34	0.30
INH + EMB	1	1	0	–	–
RIF + INH + EMB	7 1	6 0	11	0.304.–616. 26	0.24
RIF + INH + SM	2 9	2 5	4	0.200.–517. 66	0.37
INH + SM + EMB	5	4	1	0.100.–980. 03	1.00
RIF + INH + SM + EMB	2	1	1	0.223–.5587 .37	0.39
MDR	158	133	25	0.410.64 –1.01	0.05

Prevalent characterization of clustered and non-clustered strains_

Characteristics	Clustered				Non-clustered
Characteristics	Beijing family n = 612	Non-Beijing family n = 46	OR (95%CI)	p-value	Beijing family n = 508	Non-Beijing family n = 267	OR (95%CI)	p-value
Sex
Men	384	32	–	–	267	177	–	–
Women	228	14	0.308.–714. 41	0.43	241	90	0.401.–506. 77	< 0.001
Age
≤ 30	187	13	–	–	176	78	–	–
30–50	232	19	0.517.–128. 45	0.72	149	67	0.618.–012. 50	1.00
≥ 50	193	14	0.418.–024. 28	1.00	183	122	1.016.5–024.1 4	0.03
Treatment history
New	507	28	–	–	443	246	–	–
Recurrent	84	14	1.533.–052. 97	0.003	61	9	0.103.2–606.5 4	0.00
Treatment failure	21	4	1.131.–41409. 73	0.05	4	12	1.752.–41062. 93	0.002
HIV status
Negative	584	37	–	–	485	260	–	–
Positive	28	9	0.009.–200. 45	0.001	23	7	0.715.–746. 16	0.24
Sputum
Negative	121	12	–	–	104	83	–	–
Positive	391	34	0.440.88 –1.75	0.72	404	184	0.410.57 –0.80	0.001
Cavity
Yes	108	7	–	–	86	42	–	–
No	504	39	0.512.–129. 74	0.84	422	225	0.713.–019. 63	0.76

DOI: https://doi.org/10.33073/pjm-2022-033 | Journal eISSN: 2544-4646 | Journal ISSN: 1733-1331

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Language: English

Page range: 371 - 380

Submitted on: Apr 15, 2022

Accepted on: Jul 9, 2022

Published on: Sep 24, 2022

Published by: Polish Society of Microbiologists

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

Beijing genotype,

prevalent characterization,

Related subjects:

Microbiology and virology

© 2022 Dong Luo, Shengming Yu, Yuyang Huang, Jiahuan Zhan, Qiang Chen, Liang Yan, Kaisen Chen, published by Polish Society of Microbiologists
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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