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Characteristics of the Cervicovaginal Microenvironment in Childbearing-Age Women with Different Degrees of Cervical Lesions and HR-HPV Positivity Cover

Characteristics of the Cervicovaginal Microenvironment in Childbearing-Age Women with Different Degrees of Cervical Lesions and HR-HPV Positivity

Open Access
|Dec 2021

Figures & Tables

graphic/j_pjm-2021-046_fig_001.jpg
Table I

Analysis of essential information in each group.

GroupCases numberAge graphic/j_pjm-2021-046_unfig_001.jpgBMI graphic/j_pjm-2021-046_unfig_002.jpg
Group 12940.08 ± 4.8323.20 ± 3.47
Group 22942.17 ± 5.1822.00 ± 2.16
Group 33240.63 ± 4.5522.32 ± 2.93
Group 44040.64 ± 5.5722.37 ± 1.62
Group 53842.43 ± 5.3122.88 ± 1.96
K-W test (H) 5.3367.640
K-W test (P) 0.2550.106

1 Group 1 – healthy women; Group 2 – high-risk HPV infection; Group 3 – low-grade squamous intraepithelial lesion; Group 4 – high-grade squamous intraepithelial lesion; Group 5 – cervical cancer

Fig. 1.

Microbiome communities of five groups.

Fig. 2.

Alpha diversity index of cervical microflora between groups. Group 1 – healthy group; Group 2 – HR-HPV infection group; Group 3 – LSIL group; Group 4 – HSIL group; Group 5 – cervical cancer group.

Fig. 3.

Beta diversity between five groups; A) beta diversity between groups; B) box plot based on weighted UniFrac beta diversity.

Fig. 4.

Abundance heatmap of different speciesat the genus level in phase 1.

Fig. 5.

Abundance heatmap of different species at the genus level in phase 2.

Fig. 6.

Co-occurrence network diagram.

DOI: https://doi.org/10.33073/pjm-2021-046 | Journal eISSN: 2544-4646 | Journal ISSN: 1733-1331
Language: English
Page range: 489 - 500
Submitted on: Aug 31, 2021
Accepted on: Nov 10, 2021
Published on: Dec 20, 2021
Published by: Polish Society of Microbiologists
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2021 QINGZHI ZHAI, WEIYI ZHANG, ZHE ZHANG, YURONG FU, YANG LI, XUEQI WANG, LI’AN LI, YUANGUANG MENG, published by Polish Society of Microbiologists
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.