Susceptibility of colistin-resistant Enterobacterales strains (n = 65) to ceftazidime, ceftazidime/avibactam, imipenem, meropenem, and meropenem/vaborbactam_
| Strains (n; %) | Colistin | mcr-1 | CAZ | CAZ/AVB | IPM | MEM | MEM/VB | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MIC (mg/l) | S | R | S | R | S | I | R | S | I | R | S | R | |||
| Value | Numer of isolates | ||||||||||||||
| K. pneumoniae (n = 45; 69.2%) | 4 | 11 | 0 | 0 | 11 | 9 | 2 | 9 | 0 | 2 | 9 | 1 | 1 | 10 | 1 |
| 8 | 4 | 0 | 4 | 0 | 4 | 0 | 4 | 0 | 0 | 4 | 0 | 0 | 4 | 0 | |
| 16 | 2 | 0 | 0 | 2 | 1 | 0 | 2 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | |
| 32 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | |
| 64 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | |
| > 64 | 26 | 0 | 14 | 12 | 24 | 2 | 19 | 1 | 6 | 19 | 2 | 5 | 23 | 3 | |
| E. coli (n = 15; 23.1%) | 4 | 4 | 0 | 2 | 2 | 4 | 0 | 4 | 0 | 0 | 4 | 0 | 0 | 4 | 0 |
| 8 | 5 | 0 | 3 | 2 | 5 | 0 | 5 | 0 | 0 | 5 | 0 | 0 | 5 | 0 | |
| 16 | 3 | 1 | 0 | 3 | 3 | 0 | 3 | 0 | 0 | 3 | 0 | 0 | 3 | 0 | |
| 32 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | |
| 64 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | |
| > 64 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | |
| E. cloacae complex (n = 3; 4.6%) | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 8 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | |
| 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 64 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| > 64 | 2 | 0 | 1 | 1 | 2 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 2 | 0 | |
| K. oxytoca (n = 2; 3.1%) | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 8 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 16 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | |
| 32 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 64 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| > 64 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | |
| Total | 65 | 3 | 28 | 37 | 59 | 6 | 52 | 3 | 10 | 53 | 5 | 7 | 61 | 4 | |
Presence of selected ESBLs and carbapenemases among colistin-resistant Enterobacterales strains (n = 65*)_
| Strains (n; %) | Colistin | Types of ESBLs | Types of carbapenemases | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| MIC (mg/l) | mcr-1 | CTX-M-1 | CTX-M-9 | TEM | SHV | KPC | NDM | OXA-48 | ||
| Value | Number of isolates | |||||||||
| K. pneumoniae (n = 45; 69.2%) | 4 | 11 | 0 | 6 | 1 | 2 | 0 | 0 | 2 | 0 |
| 8 | 4 | 0 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 16 | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | |
| 32 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 64 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| > 64 | 26 | 0 | 22 | 1 | 3 | 4 | 1 | 3 | 1 | |
| E. coli (n = 15; 23.1%) | 4 | 4 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
| 8 | 5 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| 16 | 3 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | |
| 64 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | |
| E. cloacae complex (n = 3; 4.6%) | 8 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
| > 64 | 2 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Total | 61 | 3 | 41 | 2 | 10 | 5 | 1 | 5 | 2 | |