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Gastric Microbiota Alteration in Klebsiella pneumoniae-Caused Liver Abscesses Mice

Polish Journal of Microbiology
Volume 68 (2019): Issue 2 (June 2019)
By:
Open Access
|Jun 2019

Figures & Tables

Fig. 1.

Overall structure alteration in gastric microbiota.The species richness (A) and Rank abundance curve (B) were based on OTUs analysis of the three groups. (C) PCoA of weighted UniFrac analysis plot of gastric microbiota of three groups. (D) Venn diagram showed the OTUs overlaps among the three groups. (R, healthy group; S, NKLA group; T, KLA group).
Overall structure alteration in gastric microbiota.The species richness (A) and Rank abundance curve (B) were based on OTUs analysis of the three groups. (C) PCoA of weighted UniFrac analysis plot of gastric microbiota of three groups. (D) Venn diagram showed the OTUs overlaps among the three groups. (R, healthy group; S, NKLA group; T, KLA group).

Fig. 2.

The differences in gastric microbiota composition between healthy and KLA groups by LEfSe analysis. Taxonomic cladogram (A) and Linear discriminative analysis (LDA) scores (B) exhibited the different enriched bacteria taxa between healthy group (Red) and KLA group (Green). All of the taxa showed in the figure with LDA threshold value > 2.
The differences in gastric microbiota composition between healthy and KLA groups by LEfSe analysis. Taxonomic cladogram (A) and Linear discriminative analysis (LDA) scores (B) exhibited the different enriched bacteria taxa between healthy group (Red) and KLA group (Green). All of the taxa showed in the figure with LDA threshold value > 2.

Fig. 3.

Comparing the differences at the relative abundance of bacterial sequences at the different levels including phylum, order, family and genus level among three groups. (Mann-Whitney U test, *: p < 0.05).
Comparing the differences at the relative abundance of bacterial sequences at the different levels including phylum, order, family and genus level among three groups. (Mann-Whitney U test, *: p < 0.05).

Fig. 4.

Kp1002 oral inoculation changes gastric and intestinal defensins and serum inflammatory cytokines.Both β-defensin 1 concentration in the intestine (A) and stomach (E) showed a great increase. The concentration of β-defensin 2 (B), α-defensin 5 (C) and α-defensin 6 (D) in intestine showed a significant increase. The levels of serum cytokines IL-1β (F) and TNF-α (G) also increased. (One-way ANOVA analysis, *: p < 0.05).
Kp1002 oral inoculation changes gastric and intestinal defensins and serum inflammatory cytokines.Both β-defensin 1 concentration in the intestine (A) and stomach (E) showed a great increase. The concentration of β-defensin 2 (B), α-defensin 5 (C) and α-defensin 6 (D) in intestine showed a significant increase. The levels of serum cytokines IL-1β (F) and TNF-α (G) also increased. (One-way ANOVA analysis, *: p < 0.05).
DOI: https://doi.org/10.33073/pjm-2019-026 | Journal eISSN: 2544-4646 | Journal ISSN: 1733-1331
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Language: English
Page range: 247 - 254
Submitted on: Jan 16, 2019
Accepted on: Mar 24, 2019
Published on: Jun 28, 2019
Published by: Polish Society of Microbiologists
In partnership with: Paradigm Publishing Services
Publication frequency: 4 times per year
Keywords:
serotype K1,
defensins,
gastric mucosal microbiota,
High-throughput pyrosequencing,
liver abscess
Related subjects:
Life sciences,
Microbiology and virology

© 2019 NAN CHEN, TONG-TONG JIN, WEN-NING LIU, DONG-QING ZHU, YING-YING CHEN, YUE-LIANG SHEN, ZONG-XIN LING, HONG-JIE WANG, LI-PING ZHANG, published by Polish Society of Microbiologists
This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 License.

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