References
- Abdul Khalil, H.P.S., Davoudpour, Y., Bhat, A.H., Jawaid, M., and Hossain, M.S., 2020. Thermal degradation and structural properties of PVA/CMC/citric acid/glycerol bio-blend film. Polymer Bulletin, 79, 12897–12919. DOI: 10.1007/s00289-021-03693-y
- Al-Jarwany, Q.A., Habeeb, S.A., Bakly, A. AK. and Walton, C.D., 2024. Fabrication and fluorescence analysis of rhodamine dyes in polycarbonate serpentine microfluidic system. Journal of Fluorescence, 1–16. DOI: 10.1007/s10895-024-03984-3
- Al-Mutairi, N. H., Al-Zubiedy, A., & Al-Zuhairi, A. J. (2023). Preparation and characterization of a novel hyperbranched polyester polymers using A2+B3 monomers. Production Engineering Archives, 29(1), 28–36. DOI: 10.30657/pea.2023.29.5
- Begum, Y.M. and Reddy, P.G., 2020. Heightening the solubility of poorly soluble fenofibrate by Solid Dispersion Technique. International Journal of Research in Pharmaceutical Sciences, 11(1).
- Benoit, D.S.W., Overby, C.T., Sims, K.R. Jr., Ackun-Farmmer, M.A., 2020. Drug delivery systems. Biomaterials Science, 4th edn. Cambridge, Academic Press, 1237–1266.
- Breitenbach, J., 2002. Melt extrusion: from process to drug delivery technology. European Journal of Pharmaceutics and Biopharmaceutics, 54(2), 107–117. DOI: 10.1016/S0939-6411(02)00061-9
- Castro, J.M., Montalbán, M.G., Martínez-Pérez, N., García-Quesada, J.C., et al., 2023. Thermoplastic starch/polyvinyl alcohol blends modification by citric acid–glycerol polyesters. International Journal of Biological Macromolecules, 244, 125478. DOI: 10.1016/j.ijbiomac.2023.125478.
- Coates, J., 2000. Interpretation of Infrared Spectra, a Practical Approach. In: R.A. Meyers and M.L. McKelvy, eds., Encyclopedia of Analytical Chemistry. Chichester: John Wiley & Sons Ltd., 10815–10837. DOI: 10.1002/9780470027318.a5606.
- Corrie L., Ajjarapu S., Banda S., Parvathaneni M., Bolla P.K., Kommineni N. (2019). Development of Ternary Amorphous Solid Dispersions Manufactured by Hot-Melt Extrusion and Spray-Drying ─ Comparison of In Vitro and In Vivo Performance. Journal of Pharmaceutical Sciences, 108(9), 3063-3073.
- Donnelly, R.F., Singh, T.R.R. and Woolfson, A.D., 2010. Microneedle-based drug delivery systems: Microfabrication, drug delivery, and safety. Drug Delivery, 17(4), 187–207. DOI: 10.3109/10717541003667798
- El Andaloussi, S., Mäger, I., Breakefield, X.O. and Wood, M.J.A., 2013. Extracellular vesicles: Biology and emerging therapeutic opportunities. Nature Reviews Drug Discovery, 12(5), 347–357. DOI: 10.1038/nrd3978
- Ghanbarzadeh, B. and Almasi, H., 2013. Biodegradable polymers. IntechOpen. DOI: 10.5772/56230.
- Ghorab, M.M. and Gaber, M.H., 2017. Recent advancements in melt extrusion for controlled drug delivery systems. International Journal of Pharmaceutics, 532(1), 56–67.
- Goole, J. and Amighi, K., 2016. 3D printing in pharmaceutics: A new tool for designing customized drug delivery systems. International Journal of Pharmaceutics, 499(1–2), 376–394. DOI: 10.1016/j.ijpharm.2015.12.071
- He, Z. and Feng, L., 2016. Optimization of melt extrusion parameters for the production of drug-polymer solid dispersions. International Journal of Pharmaceutics, 509(1–2), 52–60.
- Hassan, C. M., & Peppas, N. A. (2000). Structure and applications of poly(vinyl alcohol) hydrogels. Advances in Polymer Science, 153, 37–65.
- Khosravi, A., Callegaro, L., Malekjani, N., Saffari, M., & Passerini, N. (2021). Melt extrusion for controlled drug delivery systems: Challenges and opportunities. European Journal of Pharmaceutics and Biopharmaceutics, 158, 89–101. DOI: 10.1016/j.ejpb.2020.11.004.
- Kinikar, R. and Kuchekar, A., 2022. Recent advances in hot melt extrusion and its applications. HU Journal of Pharmaceutical Sciences, 31–45. DOI: 10.52794/hujpharm.961794.
- Kizil, R., Irudayaraj, J. and Seetharaman, K., 2002. Characterization of irradiated starches by using FT-Raman and FTIR spectroscopy. Journal of Agricultural and Food Chemistry, 50(14), 3912–3918. DOI: 10.1021/jf011652p.
- Krumova, M., López, D., Benavente, R., Mijangos, C. and Pereña, J.M., 2000. Effect of crosslinking on the mechanical and thermal properties of poly(vinyl alcohol). Polymer, 41(26), 9265–9272. DOI: 10.1016/S0032-3861(00)00264-3.
- Lee, S., Kim, H., Park, J., & Cho, S. (2015). Hydrophilic and hydrophobic interactions in PVA-based biocomposites. Polymer Bulletin, 72(2), 397–407. DOI: 10.1007/s00289-014-1276-3
- Li, C., Wang, J., Wang, Y., Gao, H. and Wei, G., 2019. Recent progress in drug delivery. Acta Pharmaceutica Sinica B, 9(6), 1145–1162. DOI: 10.1016/j.apsb.2019.08.003
- Li, J. and Mooney, D.J., 2016. Designing hydrogels for controlled drug delivery. Nature Reviews Materials, 1(12), 16071. DOI: 10.1038/natrevmats.2016.71
- Li, S., Tian, Y., Jones, D.S., Andrews, G.P., 2016. Optimising drug solubilisation in amorphous polymer dispersions: Rational selection of hot-melt extrusion processing parameters. AAPS PharmSciTech, 17, 200–213. DOI: 10.1208/s12249-015-0403-2.
- Liechty, W.B., Kryscio, D.R., Slaughter, B.V. and Peppas, N.A., 2010. Polymers for drug delivery systems. Annual Review of Chemical and Bio-molecular Engineering, 1, 149–173. DOI: 10.1146/annurev-chembioeng-073009-100847.
- Liu, J., Zhang, Y., Li, H., Liu, C., Quan, P. and Fang, L., 2023. The role of hydrophilic/hydrophobic group ratio of polyvinyl alcohol on the miscibility of amlodipine in orodispersible films: From molecular mechanism study to product attributes. International Journal of Pharmaceutics, 630, 122383. DOI: 10.1016/j.ijpharm.2022.122383.
- Maniruzzaman, M., Morgan, D. J., Mendham, A. P., Pang, J., Snowden, M. J., & Douroumis, D. (2012). Drug–polymer interactions in hot-melt extrusion: From physical mixtures to molecular dispersions. International Journal of Pharmaceutics, 438(1–2), 111–119. DOI: 10.1016/j.ijpharm.2012.08.001
- Mansur, H.S., Oréfice, R.L., Mansur, A.A.P., 2004. Characterization of poly(vinyl alcohol)/poly(ethylene glycol) hydrogels and PVA-derived hybrids by small-angle X-ray scattering and FTIR spectroscopy. Polymer, 45(21), 7193–7202. DOI: 10.1016/j.polymer.2004.08.036.
- Marshell, A.L.J., Frenzel, A., Schirrmann, T., Schüngel, M. and Dübel, S., 2011. Targeting antibodies to the cytoplasm. mAbs, 3(1), 3–16. DOI: 10.4161/mabs.3.1.14110
- Mishra, V., Negi, S., Kar, S., Sharma, A., Rajbahadur, Y. and Kumar, A., 2022. Recent advances in fused deposition modeling based additive manufacturing of thermoplastic composite structures: A review. Journal of Thermoplastic Composite Materials, May 2022. DOI: 10.1177/08927057221102857.
- Okwuosa, T.C. and Harrison, J.E., 2018. Melt extrusion and solid dispersion systems for improved drug delivery. Pharmaceutical Technology, 42(6), 60–68.
- Osswald, T.A. and Hernández-Ortiz, J.P., 2013. Polymer processing: modeling and simulation. Carl Hanser Verlag GmbH Co KG. DOI: 10.3139/9783446412866.
- Parvathaneni, M., Heera, B. and Sudhakar, B., 2022. A review on hot melt extrusion coupled novel drug delivery systems. Journal of Drug Delivery and Therapeutics, 12(5), 201–207. 10.22270/jddt.v12i5.5646
- Patel, D. and Patel, M., 2014. Melt extrusion: A promising tool for improving the solubility and bioavailability of poorly water-soluble drugs. International Journal of Pharmaceutical Sciences and Research.
- Patel, S.S., Rathi, A., 2015. Advancements in melt extrusion: Impact on drug delivery systems and pharmaceutical applications. Expert Opinion on Drug Delivery, 12(9), 1467–1482.
- Patil, H., Tiwari, R.V. and Repka, M.A., 2016. Hot-melt extrusion: from theory to application in pharmaceutical formulation. AAPS PharmSciTech, 17, 20–42. DOI: 10.1208/s12249-015-0434-9.
- Patra, J.K., Das, G., Fraceto, L.F., Campos, E.V.R., Rodriguez-Torres, M.P., Acosta-Torres, L.S., Diaz-Torres, L.A., Grillo, R., Swamy, M.K., Sharma, S., Habtemariam, S. and Shin, H.S., 2018. Nano based drug delivery systems: Recent developments and future prospects. Journal of Nanobiotechnology, 16(1), 71. DOI: 10.1186/s12951-018-0392-8.
- PerkinElmer. (2020). Fourier Transform Infrared Spectroscopy (FTIR) Guide. Waltham, MA: PerkinElmer, Inc. Available at: https://www.perkinelmer.com
- Pham, Q.D., Topgaard, D., Sparr, E., 2017. Cyclic exposure of skin to surfactant SDS causes irreparable alterations of molecular and structural organization. International Journal of Pharmaceutics, 526(1–2), 42–52. DOI: 10.1016/j.ijpharm.2017.04.071.
- Qian, F., Huang, J., Hussain, M.A., 2010. Drug–polymer solubility and miscibility: Stability consideration and practical challenges in amorphous solid dispersion development. Journal of Pharmaceutical Sciences, 99(7), 2941–2947. DOI: 10.1002/jps.22051.
- Rao, N. V., Ko, H., Lee, J., & Park, J. H. (2018). Recent progress and advances in stimuli-responsive polymers for cancer therapy. Frontiers in Bioengineering and Biotechnology, 6, 110. DOI: 10.3389/fbioe.2018.00110.
- Rana, M.M., Ahmad, N., Kumar, R., 2022. Fourier Transform Infrared Spectroscopy: Applications, Advances, and Challenges in Pharmaceutical Sciences. International Journal of Pharmaceutical Sciences and Research, 13(1), 1–11. DOI: 10.13040/IJPSR.0975-8232.13(1).1-11.
- Ren, L., Yan, X., Zhou, J., Tong, J., Su, X. (2017). Influence of citric acid on the properties of glycerol-plasticized starch/poly(vinyl alcohol) biodegradable films. International Journal of Biological Macromolecules, 98, 341–352. DOI: 10.1016/j.ijbiomac.2017.01.123
- Repka, M.A., Bandari, S., Kallakunta, V.R., Vo, A.Q., McFall, H., Pim-parade, M.B. and Narala, S., 2018. Melt extrusion: process to product. Expert Opinion on Drug Delivery, 15(9), 767–785. DOI: 10.1080/17425247.2018.1505869.
- Repka, M. A., Battu, S. K., Upadhye, S. B., Thumma, S., Crowley, M. M., Zhang, F., Martin, C., & McGinity, J. W. (2007). Pharmaceutical Applications of Hot-Melt Extrusion: Part II. Drug Development and Industrial Pharmacy, 33(10), 1043–1057. DOI: 10.1080/03639040701525627
- Rowe, R. C., Sheskey, P. J., & Owen, S. C. (2006). Handbook of Pharmaceutical Excipients, 6th ed., Pharmaceutical Press.
- Sabzi, M., Moini Jazani, O., 2019. FTIR spectroscopy for analysis of polymers. In: Modern Polymer Spectroscopy Techniques. Springer, Cham, 123–150. DOI: 10.1007/978-3-030-02683-3_6
- Sabr, O. H., Obaid, M. N., Al-Mutairi, N. H., Krynke, M., & Mielczarek, K. (2024). Study the effect of zinc oxide nanoparticles on degradation, an… thermal and morphological properties of polyvinyl alcohol films. Production Engineering Archives, 30(4), 528–536. DOI: 10.30657/pea.2024.30.49
- Sakr, T.M., Essa, S.A., Motaleb, M.A., 2019. Advanced strategies in hot-melt extrusion for improved drug delivery. Drug Discovery Today, 24(9), 1894–1903. DOI: 10.1016/j.drudis.2019.05.013.
- Sari, S., Harnkarnsujarit, N., & Huang, Y. (2017). Investigation of polymer–plasticizer interactions in biodegradable films: Effects on mechanical and thermal properties. Journal of Applied Polymer Science, 134(18), 44987. DOI: 10.1002/app.44987
- Satturwar, P., Fulzele, S., Dorle, A., 2002. Biodegradation and in vivo bio-compatibility of rosin: a natural film-forming polymer. AAPS PharmSciTech, 3(2), 48–53. DOI: 10.1208/pt030207.
- Shah, S., Maddineni, S., Lu, J., Repka, M.A., 2013. Melt extrusion with poorly soluble drugs. International Journal of Pharmaceutics, 453(1), 233–252. DOI: 10.1016/j.ijpharm.2013.01.052.
- Shi, R., Zhang, Z., Liu, Q., Han, Y., Zhang, L., Chen, D., and Tian, W., 2008. Characterization of citric acid/glycerol co-plasticized thermoplastic starch prepared by melt blending. Carbohydrate Polymers, 74(4), 763–770. DOI: 10.1016/j.carbpol.2008.04.037
- Shi, R., Zhang, Z., Xie, W., Chen, X., and Tian, W., 2008. Thermal and oxidative degradation of PVA/starch blends. Carbohydrate Polymers, 71(4), 614–620. DOI: 10.1016/j.carbpol.2007.07.009
- Sinha, V.R., Trehan, A., 2003. Biodegradable microspheres for protein delivery. Journal of Controlled Release, 90(3), 261–280. DOI: 10.1016/S0168-3659(03)00200-7.
- Sinha-Ray, S., Zhang, Y., Yarin, A.L., 2015. Coaxial electrospinning: Applications and recent advances. In: Coaxial Electrospinning: Advances and Applications, Springer, 19–50. DOI: 10.1007/978-3-319-13476-2_2.
- Stanković, M., Frijlink, H. W., & Hinrichs, W. L. J. (2015). Polymeric formulations for drug release prepared by hot melt extrusion: application and characterization. Drug Discovery Today, 20(7), 812–823. DOI: 10.1016/j.drudis.2015.01.012
- Stuart, B., 2004. Infrared Spectroscopy: Fundamentals and Applications. John Wiley & Sons Ltd., Chichester, UK.
- Smith, J., & Kinch, M.S. (2011). The role of pharmaceutical industry in drug discovery. Journal of Clinical Pharmacology, 51(4), 1–5. DOI: 10.1177/0091270010395174
- Smith, J. (2011). Organic Chemistry: Principles and Mechanisms. 3rd Edition. New York: McGraw-Hill Education. ISBN: 978-0-07-340276-1.
- Teixeira, M. A., Paiva, M. C., & Amorim, M. T. P. (2021). Plasticizers in polymer systems: Effects on glass transition, crystallinity, mechanical and barrier properties. Polymers, 13(17), 2879. DOI: 10.3390/polym13172879
- Tekade, R.K., Jain, N.K., & Jain, A. (2017). Targeted Drug Delivery: Concepts and Applications. Journal of Drug Delivery and Therapeutics, 7(3), 1–2. DOI: 10.22270/jddt.v7i3.1483
- Thermo Fisher Scientific. (2017). FTIR Spectroscopy: Theory and Instrumentation. Waltham, MA: Thermo Fisher Scientific. Available at: https://www.thermofisher.com
- Tsioptsias, C., Markopoulos, G., Tzoumaki, M. V., Kasapis, S., & Panayiotou, C. (2023). Thermal degradation and stabilization of poly(vinyl alcohol) with citric acid and glycerol as additives. Polymer Degradation and Stability, 212, 110603. DOI: 10.1016/j.polymdegradstab.2023.110603
- Tung, J.M., Xu, X., Smith, A.M., Shur, J., Fegely, K., Djuric, D., Johnston, K.P., 2010. Amorphous solid dispersions of itraconazole and enteric polymers prepared by spray drying. International Journal of Pharmaceutics, 383(1–2), 228–237. DOI: 10.1016/j.ijpharm.2009.08.036.
- Wagner, F.C., Feucht, M.J., Konstantinidis, L., Hohloch, L., Yilmaz, T., Bernstein, A., Südkamp, N.P., & Reising, K. (2020). Biomechanical evaluation of two innovative locking implants for comminuted olecranon fractures under high-cycle loading conditions. Injury, 51(1), 74–80. DOI: 10.1016/j.injury.2019.10.020
- Wakaskar, R.R. (2017). Types of Nanocarriers–Formulation Method and Applications. Journal of Bioequivalence and Bioavailability, 9(3), e77. DOI: 10.4172/jbb.10000e77
- Wegiel, L.A., Zhao, Y., Mauer, L.J., Edgar, K.J., Taylor, L.S., 2013. Evaluation of polymeric carriers for the formation of supersaturated solutions of posaconazole: amorphous solid dispersions vs. polymeric micelles. Molecular Pharmaceutics, 10(7), 2662–2673. DOI: 10.1021/mp4001477.
- Williams, H.D., Trevaskis, N.L., Charman, S.A., Shanker, R.M., Charman, W.N., Pouton, C.W., Porter, C.J.H., 2013. Strategies to address low drug solubility in discovery and development. Pharmacological Reviews, 65(1), 315–499. DOI: 10.1124/pr.112.005660.
- Xiao, Q., Tong, Q., Zhou, Y., Deng, F., & Xiao, C. (2019). Effect of citric acid on the properties of glycerol-plasticized thermoplastic starch/poly(vinyl alcohol) blends. Starch/Stärke, 71(1–2), 1800120. DOI: 10.1002/star.201800120
- Xue, J., Wu, T., Dai, Y., & Xia, Y. (2014). Electrospinning and electrospun nanofibers: Methods, materials, and applications. Chemical Reviews, 114(12), 6130–6185. DOI: 10.1021/cr400512f
- Zhang, Y., Huo, M., Zhou, J., Zou, A., Li, W., Yao, C. and Xie, S., 2010. DDSolver: an add-in program for modeling and comparison of drug dissolution profiles. AAPS Journal, 12(3), 263–271. DOI: 10.1208/s12248-010-9185-1.