Abstract
Hepatocellular carcinoma is one of the most common cancers worldwide and a major cause of death in many countries. To evaluate the clinicopathological correlations of proliferative activity in patients with hepatocellular carcinoma, Ki-67 antigen expression was examined using immunohistochemical staining with monoclonal antibody MIB1. Consecutive 40 patients who had undergone surgical resection for the treatment of HCC from January 2005 to December 2009 were enrolled in our study. The study group comprised 32 men and 8 women ranging from 27 to 76 (mean age, 54.6 SD±11.7) years of age. Expression of Ki-67 was negative in 22.5% of the 40 cases and Ki-67 positive expression “+”, “++”, “+++” was found in 11, 7 and 13 cases of hepatocellular carcinoma respectively. There are no statistically significant differences of the Ki-67 mean between age, sex distribution, dimension of the tumors, pattern of the tumor and Edmondson -Steiner grading.