The Effect of Amphotericin B on the Lifespan, Body-surface Protein Concentrations, and DNA Methylation Levels of Honey Bees (Apis mellifera)

Aneta Strachecka; Grzegorz Borsuk; Krzysztof Olszewski; Jerzy Paleolog; Mariusz Gagoś; Jacek Chobotow; Agnieszka Nawrocka; Magdalena Gryzińska; Milena Bajda

doi:10.2478/v10289-012-0028-4

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The Effect of Amphotericin B on the Lifespan, Body-surface Protein Concentrations, and DNA Methylation Levels of Honey Bees (Apis mellifera)

Journal of Apicultural Science

Volume 56 (2012): Issue 2 (December 2012)

By: Aneta Strachecka, Grzegorz Borsuk, Krzysztof Olszewski, Jerzy Paleolog, Mariusz Gagoś, Jacek Chobotow, Agnieszka Nawrocka, Magdalena Gryzińska and Milena Bajda

Open Access

|Jan 2013

Abstract

Three groups of caged bees were fed with sugar syrup (the control), sugar syrup supplemented with amphotericin B (AmB) in a dose of 0.5 mg/ml, and sugar syrup with AmB in a dose of 0.25 mg/ ml. Amphotericin B shortened the life span of the bees and reduced the level of global DNA methylation compared to the control, however, it increased the body-surface protein concentrations. In the hindguts of the bees, there were found AmB deposits. Honeybees appear to be a useful model for studying the side effects of anti-fungal AmB therapy. Among other things, epigenetic changes and senescence acceleration are considered to be the side effects of the therapy.

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Articles in this issue

DOI: https://doi.org/10.2478/v10289-012-0028-4 | Journal eISSN: 2299-4831 | Journal ISSN: 1643-4439

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Language: English

Page range: 107 - 113

Published on: Jan 12, 2013

Published by: Research Institute of Horticulture

In partnership with: Paradigm Publishing Services

Publication frequency: 2 issues per year

Keywords:

protein concentration.

Related subjects:

Life sciences,

Zoology,

Life sciences, other

© 2013 Aneta Strachecka, Grzegorz Borsuk, Krzysztof Olszewski, Jerzy Paleolog, Mariusz Gagoś, Jacek Chobotow, Agnieszka Nawrocka, Magdalena Gryzińska, Milena Bajda, published by Research Institute of Horticulture
This work is licensed under the Creative Commons License.

Volume 56 (2012): Issue 2 (December 2012)