Aging Process in Chromatin of Animals

Maciej Wnuk; Monika Bugno-Poniewierska; Anna Lewińska; Bernadetta Oklejewicz; Tomasz Ząbek; Ewa Słota

doi:10.2478/v10220-012-0025-3

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Aging Process in Chromatin of Animals

Annals of Animal Science

Volume 12 (2012): Issue 3 (July 2012)

By: Maciej Wnuk, Monika Bugno-Poniewierska, Anna Lewińska, Bernadetta Oklejewicz, Tomasz Ząbek and Ewa Słota

Open Access

|Jul 2012

Abstract

The aging process is a variable, stochastic and pleiotropic phenomenon which is regulated by different environmental and genetic factors. The age-associated changes, which occur at the molecular and cellular levels and disturb biological homeostasis, may directly or indirectly contribute to aging, causing apoptosis or cellular senescence and consequently leading to the death of the organism. In this context, it is particularly interesting to observe changes in somatic cell chromatin. In the present paper, we summarized the knowledge on the biological aspects of aging with special consideration of age-related changes in chromatin like DNA damage, shortening telomeres or age-related changes in methylation of DNA.

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Articles in this issue

DOI: https://doi.org/10.2478/v10220-012-0025-3 | Journal eISSN: 2300-8733 | Journal ISSN: 1642-3402

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Language: English

Page range: 301 - 309

Published on: Jul 24, 2012

Published by: National Research Institute of Animal Production

In partnership with: Paradigm Publishing Services

Publication frequency: Volume open

Keywords:

aging,

Related subjects:

Zoology,

© 2012 Maciej Wnuk, Monika Bugno-Poniewierska, Anna Lewińska, Bernadetta Oklejewicz, Tomasz Ząbek, Ewa Słota, published by National Research Institute of Animal Production
This work is licensed under the Creative Commons License.

Volume 12 (2012): Issue 3 (July 2012)