Synthesis and antimicrobial properties of binaphthyl derived quaternary ammonium bromides

R. Mikláš; N. Miklášová; M. Bukovský; F. Devínsky

doi:10.2478/v10219-012-0017-5

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Synthesis and antimicrobial properties of binaphthyl derived quaternary ammonium bromides

European Pharmaceutical Journal

Volume 59 (2012): Issue 1 (June 2012)

By: R. Mikláš, N. Miklášová, M. Bukovský and F. Devínsky

Open Access

|Aug 2012

Abstract

(S)-N-(2-(4,5-dihydro-3H-dinaphtho[2,1-c:1',2'-e]azepin-1-yl)ethyl)-N, N-dimethyl-N-dodecyl ammonium bromide (S)-1a and (S)-N-(2-(4,5-dihydro-3H-dinaphtho[2,1-c:1',2'-e]azepin-1-yl)ethyl)-N, N-dimethyl-N-tetradecylammonium bromide (S)-1b have been synthesized as optically active quaternary ammonium salts starting from 1,1'-binaphthyl-2,2'-diol. Their antimicrobial activity expressed as minimal inhibition concentration (MIC) was tested against Gram-positive human pathogenic bacteria S. Aureus, Gram-negative bacteria E. coli and human fungal pathogen C. Albicans.

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Articles in this issue

DOI: https://doi.org/10.2478/v10219-012-0017-5 | Journal eISSN: 2453-6725 (formerly 1338-6786) | Journal ISSN: 0301-2298

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Language: English

Page range: 39 - 47

Published on: Aug 13, 2012

Published by: Comenius University in Bratislava, Faculty of Pharmacy

In partnership with: Paradigm Publishing Services

Keywords:

quaternary ammonium bromides,

antimicrobial activity,

binaphthyl

Related subjects:

Pharmacy,

Pharmacy, other

© 2012 R. Mikláš, N. Miklášová, M. Bukovský, F. Devínsky, published by Comenius University in Bratislava, Faculty of Pharmacy
This work is licensed under the Creative Commons License.

Volume 59 (2012): Issue 1 (June 2012)