Comparison of classic and derivative UV spectrophotometric methods for determination of dextromethorphani hydrobromidum

J. Drozd

doi:10.2478/v10219-012-0014-8

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Comparison of classic and derivative UV spectrophotometric methods for determination of dextromethorphani hydrobromidum

European Pharmaceutical Journal

Volume 59 (2012): Issue 1 (June 2012)

By: J. Drozd

Open Access

|Aug 2012

Abstract

A method for the fast determination of dextromethorphani hydrobromidum in pharmaceutical preparations by classic spectrophotometry - zero and first-, second- and third-order derivative spectrophotometry, using "peak - peak" (P - P) and "peak - zero" (P - O) measurements has been performed. The calibration curves are linear within the concentration range of 1.0 - 25.0 μg ml^-1 for dextromethorphani hydrobromidum. The procedure is simple, rapid and the results are reliable.

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