Abstract
The aim of the study was to evaluate the ability of lipid A analogues obtained from the native strain (LAS) or strains of E. coli resistant to either an amine oxide (modLANO) or to a quaternary ammonium salt (modLBr) to reduce myocardial ischaemia and reperfusion injury in rats. The 0.5, 2, 4, 24 h pretreatment of rats with lipid A from a strain of E. coli resistant to an amine oxide (modLANO 0.5 mg/kg i.v.) in an in vitro model of myocardial ischemia lasting 10 min followed by 10 min reperfusion did not reduce the myeloperoxidase (MPO) and complement activities. In an in vivo study, the 24 h pretreatment of rats with modLANO in a dose of 0.5 mg/kg i.v. only significantly decreased both the MPO and complement activities in serum (p<0.01). The analogues of lipid A indicate abilities to influence the myocardial ischaemia-reperfusion injury in times-dependent and structures-dependent ways.