Influence of Invasion of Intracellular Parasites on Platelet Response in Dogs Based on Clinical Cases

Snarska, Anna; Pomianowski, Andrzej; Krystkiewicz, Wioletta; Sobiech, Przemysław; Lew, Sylwia; Bednarek, Dariusz

doi:10.2478/v10213-012-0091-4

Abstract

Blood morphology in dogs infected with intracellular parasites of the genera Babesia and Ehrlichia was examined. The parasites were detected in peripheral blood smears stained by the May-Grünwald-Giemsa method. During the parasitic invasion, a decrease in thrombocyte counts was observed. This was connected with forming platelet aggregates. It was noted that the number of giant platelets simultaneously increased.

References

1. Adaszek Ł., Martinez A.C., Winiarczyk S.: The factors affecting the distribution of babesiosis in dogs in Poland. Vet Parasitol 2011, 181, 160-16510.1016/j.vetpar.2011.03.05921524856
Search in Google Scholar
2. Bout D., Joseph M., Pontet M., Vorng H., Deslee D., Capron A.: Rat resistance to schistosomiasis: plateletmediated cytotoxicity induced by C-reactive protein. Science 1986, 231, 153-156.10.1126/science.30799163079916
Search in Google Scholar
3. Chadderdon R.C., Cappello M.: The hookworm platelet inhibitor: functional blockade of integrins GP IIIb/IIIa (allbb3) and GP Ia/IIa (a/2b1) inhibit platelet aggregation and adhesion in vitro. J Infect Dis 1999, 179, 1235-1241.10.1086/31472410191228
Search in Google Scholar
4. Davis W.M.: Hapten-induced immune-mediated thrombocytopenia in a dog. J Am Vet Med Assoc 1984, 184, 976-977.
Search in Google Scholar
5. Dunn J.K., Heath M.F., Jefferies A.R., Blackwood L., McKay J.S., Nicholls P.K.: Diagnosis and hematologic features of probable essential thrombocythemia in two dogs. Vet Clin Pathol 1999, 28, 131-138.10.1111/j.1939-165X.1999.tb01063.x
Search in Google Scholar
6. El-Bassiouni N.E., El-Bassiouny A.E., Akl M.M., El- Khayat H.R.: Fibronectin, platelet factor 4 and betathromboglobulin in endemic hepatosplenic schistosomiasis: relation to acute hematemesis. Haemostasis 1997, 27, 39-4810.1159/0002174329097085
Search in Google Scholar
7. Ishikawa N., Goyal P.K., Mahida Y.R., Li K.F., Wakelin D.: Early cytokine responses during intestinalis parasitic infections. Immunology 1998, 93, 257-263.10.1046/j.1365-2567.1998.00412.x13641869616376
Search in Google Scholar
8. Joseph M., Gounni A.S., Kusnierz J.P., Vorng H., Sarfati M., Kinet J.P., Tonnel A.B., Capron A., Capron M.: Expression and functions of the high affinity IgE receptor on human platelets and megakaryocyte precursors. Eur J Immunol 1997, 27, 2212-2218.10.1002/eji.18302709149341761
Search in Google Scholar
9. Kakoma I., Hansen R.D., Anderson B.E., Hanley T.A., Sims K.G., Liu L., Bellamy C., Long M.T., Baek B.K.: Cultural, molecular and immunological characterization of the etiologic antigen for atypical canine ehrlichiosis. J Clin Microbiol 1994, 32, 170-175.10.1128/jcm.32.1.170-175.19942629908126175
Search in Google Scholar
10. Kotomski G.: Babesiosis of dogs. Mag Wet 2002, 11, 5-10.
Search in Google Scholar
11. Matowicka-Karna J., Kemona H.: Phagocytic activity of blood platelets in the course of various parasitic diseases. Przeg Lek 2002, 59, 820-822.
Search in Google Scholar
12. Matowicka-Karna J., Kemona H., Dymicka-Piekarska V., Butkiewicz A.: Activation of blood platelets in echinococcosis- CD62P and CD63 expression. Parasitol Res 2006, 98, 214-217.10.1007/s00436-005-0038-216333666
Search in Google Scholar
13. Mikulska-Skupień E., Procajło A.: Ehrlichiosis in dogs - an own case. Medycyna Wet 2009, 65, 480-483.
Search in Google Scholar
14. Momi S., Perito S., Mezzasoma A.M., Bistoni F., Gresele R.: Involvement of platelets in experimental mouse trypanosomiasis: evidence of mouse platelet cytotoxity against Trypanosoma equiperdum. Exp Parasitol 2000, 95, 136-143.10.1006/expr.2000.451710910715
Search in Google Scholar
15. Pinkiewicz E., Grzebuła S.: A case of babesiosis in dog. Medycyna Wet 1996, 22, 143-144.
Search in Google Scholar
16. Polack B., Peyron F., Auriault C.: Platelet cytotoxicity against parasites. Nouv Rev Fr Haematol 1991, 33, 317-322.
Search in Google Scholar
17. Reagan W.J., Murphy D., Battaglino M., Bonney P., Boone T.C.: Antibodies to canine granulocyte colonystimulating factor. J Clin Invest 1991, 87, 704-710.
Search in Google Scholar
18. Ridel P.R., Auriault C., Darcy F., Pierce R.J., Leite P., Santoro F., Neyrinck J.L., Kusnierz J.P., Capron A.: Protective role of IgE in immunocompromised rat toxoplasmosis. J Immunol 1988, 141, 976-983.10.4049/jimmunol.141.3.978
Search in Google Scholar
19. Roszel J., Prier J.E., Koprowska I.: The occurrence of megakaryocytes in the peripheral blood of dogs. J Am Vet Med Assoc 1965, 147, 133-137.
Search in Google Scholar
20. Snarska A., Romaniuk K.: Haematological changes in primitive Polish horses infected with Gasterophilusintestinalis horsefly. Medycyna Wet 2005, 61, 514-517.
Search in Google Scholar
21. Stanssens P., Bergum P.W., Gansemans Y., Jesper L., Laroche Y., Huang S., Maki S., Messens J., Lauwereys M., Cappello M., Hotez P.J., Lasters I., Vlasuk G.P.: Anticoagulant repertoire of the hookworm Ancylostomacaninum. Proc Natl Acad Sci USA 1996, 93, 2149-2154.10.1073/pnas.93.5.2149
Search in Google Scholar
22. Umekita L.F., Mota I.: In vitro lysis of sensitized Trypanosoma cruzi by platelets: role of C3b receptors. Parasite Immunol 1989, 11, 561-566.10.1111/j.1365-3024.1989.tb00689.x
Search in Google Scholar
23. Viens P., Dubois R., Kongshavn P.A.: Platelet activity in immune lysis of Trypanosoma musculi. Int J Parasitol 1983, 13, 527-530.10.1016/S0020-7519(83)80023-X
Search in Google Scholar
24. Watson A.D.J., Wright R.G.: The ultrastructure of inclusion in blood cells of dogs with distemper. J Comp Pathol 1974, 84, 417-427.10.1016/0021-9975(74)90017-6
Search in Google Scholar
25. Williams D.A., Maggio P.L.: Canine idiopathic thrombocytopenia: clinical observations and long- term follow up in 54 cases. J Am Vet Med Assoc 1984, 185, 660-663.
Search in Google Scholar
26. Zygner W., Jaros S., Wedrychowicz H.: Prevalence of Babesia canis, Borelia afzelli and Anaplasmaphagocytophilum infection in hard ticks remowed from dog in Warsaw (central Poland). Vet Parasitol 2008, 153, 139-142.10.1016/j.vetpar.2008.01.03618328630
Search in Google Scholar
27. Zygner W., Gójska O., Rapacka G., Jaros D., Wędrychowicz H.: Hematological changes during the course of canine babesiosis caused by large Babesia in domestic dogs in Warsaw (Poland). Vet Parasitol 2007, 145, 146-151.10.1016/j.vetpar.2006.11.00817157987
Search in Google Scholar
28. Zygner W., Gójska-Zygner O., Szmidt K The use of vincristine and cyclophosphamide in the treatment of persistent anaemia and thrombocytopenia after the invasion of Babesia canis in dogs. Życie Wet 2011, 86, 374-378.
Search in Google Scholar

Influence of Invasion of Intracellular Parasites on Platelet Response in Dogs Based on Clinical Cases

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