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Evaluation of biochemical, hematological and oxidative parameters in mice exposed to the herbicide glyphosate-Roundup® Cover

Evaluation of biochemical, hematological and oxidative parameters in mice exposed to the herbicide glyphosate-Roundup®

Interdisciplinary Toxicology
Volume 5 (2012): Issue 3 (September 2012)
By: Raquel Jasper,  Gabriel Olivo Locatelli,  Celso Pilati and  Claudriana Locatelli  
Open Access
|Jan 2013

References

  1. Ahmad I, Hamid T, Fatima M, Chand HS, Jain SK, Athar M, Raisudin S. (2000). Induction of hepatic antioxidants in freshwater catf sh (Channa puncta-tus Bloch) is a biomarker of paper mill ef uent exposure. Biochim. Biophys. Acta. 1523: 37-48.
    Search in Google Scholar
  2. Ahmad I, Pacheco M, Santos MA. (2004). Enzymatic antioxidants as an adaptation to phagocytes induced damage in Anguilla anguilla L. following in situ harbor water exposure. Ecotoxicol. Environ. Saf. 57: 290-295.
    Search in Google Scholar
  3. Amerio P, Motta A, Toto P, Pour SM, Pajand R, Feliciani C, Tulli A. (2004). Skin toxicity from glyphosate-surfactant formulation. J . Toxicol. Clin. Toxicol . 42(3): 317-319.
    Search in Google Scholar
  4. Astiz M, de Alaniz MJT, Marra CA. (2009). Ef ect of pesticides on cell survival in liver and brain rat tissues. Ecotoxicol. Environ. Saf. 72: 2025-2032.
    Search in Google Scholar
  5. Avellar de IG, Magalhães MM, Silva AB, Souza LL, Leitão AC, Hermes-Lima M. (2004). Reevaluating the role of 1,10-phenanthroline in oxidative reactions involving ferrous ions and DNA damage. Biochim. Biophys. Acta. 1675(1-3): 46-53.
    Search in Google Scholar
  6. Barcellos LJG, Kreutz LC, Rodrigues LB, Fioreze I, Quevedo RM, Cericato L, Conrad J, Soso AB, Fagundes M, Lacerda LA, Terra S. (2003). Haematologi-cal and biochemical characteristics of male jundiá (Rhamdia Quelen, Quoy & GaimaRDT, Pimelodidae): changes after acute stress. Aquacul. Res. 34: 1465-1469.
    Search in Google Scholar
  7. Benedetti AL, Vituri C de L, Trentin AG, Domingues MA, Alvarez-Silva M. (2004). The ef ects of sub-chronic exposure of Wistar rats to the herbicide Glyphosate-Biocarb. Toxicol Lett. 153(2): 227-232.
    Search in Google Scholar
  8. Bird RP, Draper HH. (1984). Comparative studies on dif erent methods of malondialdehyde determination. Methods Enzymol. 105: 299-305.
    Search in Google Scholar
  9. Bradberry SE, Proudfoot AT, Vale JA. (2004). Glyphosate poisoning. To x ico l Rev. 23(3): 159 -167.
    Search in Google Scholar
  10. Cavuşoğlu K, Yapar K, Oruç E, Yalçın E. (2011). Protective ef ect of Ginkgo bi-loba L. leaf extract against glyphosate toxicity in Swiss albino mice. J. Med. Food. 14(10): 1263-1272.
    Search in Google Scholar
  11. Chahoud I, Ligensa A, Dietzel L, Faqi AS. (1999). Correlation between maternal toxicity and embryo/fetal ef ects. Reprod Toxicol. 13 (5): 375-381.
    Search in Google Scholar
  12. Corbera M, Hidalgo M, Salvado V, Wieczorek PP. (2005). Determination of glyphofase and aminomethylphosphonic acid in natural water using the capillary electrophoresis combined with enrichment step. Anal. Chim. Acta. 540: 3-7.
    Search in Google Scholar
  13. Contardo-Jara V, Klingelmann E, Wiegand C. (2009). Bioaccumulation of glyphosate and its formulation Roundup Ultra in Lumbriculus variegatus and its ef ects on biotransformation and antixidant enzymes. Environ. Pol-lut. 157: 57-63.
    Search in Google Scholar
  14. Coutinho CFB, Tanimoto ST, Galli AG, Gustavo S, Takayama MA, Raquel B, Mazo LH. (2005). Pesticides: action mechanism, degradation and toxicity. Pesticidas 5: 65-72.
    Search in Google Scholar
  15. Dallegrave E, Mantese FD, Coelho RS, Pereira JD, Dalsenter PR, Langeloh A. (2003). The teratogenic potential of the herbicide glyphosate-Roundup in Wistar rats. Toxi co l Le t t. 142(1-2): 45 -52.
    Search in Google Scholar
  16. De Roos AJ, Zahm SH, Cantor K P, Weisemburger DD, Holmes FF, Burmeister LF, Blair A. (2003). Integrative assessment of multiple pesticides as risk factors for non-Hodgkin´s lymphoma among men. Occup. Environ. Med. 60(9): E11.
    Search in Google Scholar
  17. Druart C, Millet M, Scheif er R, Delhomme O, Raeppel C, de Vauf eury A. (2011). Snails as indicators of pesticide drift, deposit, transfer and ef ects in the vineyard. Sci. Total Environ. 409(20): 4280-4288.
    Search in Google Scholar
  18. Ellman GL. (1959). Tissue sulfhydryl groups. Arch. Biochem. Biophys. 82: 70-77.
    Search in Google Scholar
  19. Garg DK, Goyal RN. (1992). Haematological and hepatotoxic ef ects of silken styles of corn in albino rats. J. Appl. Toxicol. 12(5): 359-363.
    Search in Google Scholar
  20. Gehin A, Guyon C, Nicod L. (2006). Glyphosate-induced antioxidant imbalance in HaCaT: The protective ef ect of Vitamins C and E. Environ. Toxicol. Pharmacol. 22: 27-34.
    Search in Google Scholar
  21. Guilherme S, Gaivão I, Santos MA, Pacheco M. (2010). European eel (Anguilla anguilla) genotoxic and pro-oxidant responses following short-term exposure to Roundup® - a glyphosate based herbicide. Mutagenesis. 25(5): 523-530.
    Search in Google Scholar
  22. Glusczak L, Miron DS, Crestani M, Fonseca MB, Pedron FA, Duarte MF, Vieira VLP. (2006). Ef ect of glyphosate herbicide on acetylcholinesterase activity and metabolic and hematological parameters in piava (Leporinus obtu-sidens). Ecotoxicol. Environ. Saf. 65: 237-241.
    Search in Google Scholar
  23. Glusczak L, Miron DS, Moraes BS, Simoes RR, Schetinger MRC, Morsch VM, Loro VL. (2007). Acute ef ects of glyphosate herbicide on metabolic and enzymatic parameters of silver catf sh (Rhamdia quelen). Comp. Biochem. Physiol. 146C: 519-524.
    Search in Google Scholar
  24. Harish RS, Murugan K. (2011). Oxidative stress indices in natural populations of Avicennia alba Blume as biomarker of environmental pollution. Environ. Res. 11(8): 1070-1073.
    Search in Google Scholar
  25. Hazarika A, Sarkar SN, Hajare S, Kataria M, Malik JK. (2003). Inf uence of mala-thion pretreatment on the toxicity of anilofos in male rats: a biochemical interaction study. Toxi co l . 185: 1-8.
    Search in Google Scholar
  26. Hietanen E, Linnainmaa K, Vainio H. (1983). Ef ects of phenoxyherbicides and glyphosate on the hepatic and intestinal biotransformation activities in the rat. Acta Pharmacol. Toxicol. 53(2): 103-112.
    Search in Google Scholar
  27. Howe CM, Berrill M, Pauli DB, Helbing CC, Werr K, Veldhoen N. (2004). Toxicity of glyphosate-based pesticides to four North American frog species. Environ. Toxicol. Chem. 23: 1928-1938.
    Search in Google Scholar
  28. Kavitha P, Rao V. (2007). Oxidative stress and locomotor behavior response as biomarkers for assessing recovery status of mosquito f sh Gambusia af nis after lethal ef ect of an organophosphate pesticide, monocrotophos. Pest. Biochem. Physiol. 87: 182-18 8 .
    Search in Google Scholar
  29. Li W, Yin D, Zhou Y, Hu S, Wang L. (2003). 3,4-Dichloroaniline-induced oxida-tive stress in liver of crucian carp (Carassius auratus). Ecotoxicol. Environ. Saf. 56: 251-255.
    Search in Google Scholar
  30. Lioi MB, Scarf MR, Santoro A, Barbieri R, Zeni O, Bernardino DD, Ursini MV. (1998). Genotoxicity and oxidative stress induced by pesticides exposure in bovine lymphocyte cultures in vitro. Mutat. Res. 403: 13-20.
    Search in Google Scholar
  31. Lushchak OV, Kubrak OI, Storey JM, Lushchak VI. (2009). Low toxic herbicide Roundup induces mild oxidative stress in goldf sh tissues. Chemosphere 76: 932-937.
    Search in Google Scholar
  32. Marc J, Bellé R, Morales J, Cornier P, Mulner-Lorillon O. (2004a). Formulated glyphosate activates the DNA-response checkpoint of the cell cycle leading to the prevention of G2/M transition. To x i c o l . S c i . 82(2): 436 -242.10.1093/toxsci/kfh28115375296
    Search in Google Scholar
  33. Marc J, Mulner-Lorillon O, Bellé R. (2004b). Glyphosate-based pesticides affect cell cycle regulation. Biol. Cell. 96(3): 245-249.10.1016/j.biolcel.2003.11.01015182708
    Search in Google Scholar
  34. Martínez A, Reyes I, Reyes N. (2007). Cytotoxicity of the herbicide glyphosate in human peripheral blood mononuclear cells. Biomedica 27(4): 594-604.
    Search in Google Scholar
  35. Modesto KA, Martinez CBR. (2010a). Roundup causes oxidative stress in liver and inhibits acetylcholinesterase in muscle and brain of the f sh Prochilo-dus lineatus. Chemosphere. 78: 294-299.10.1016/j.chemosphere.2009.10.04719910015
    Search in Google Scholar
  36. Modesto KA, Martinez CBR. (2010b). Ef ects of Roundup Transorb on f sh: He-matology, antioxidant defenses and acetylcholinesterase activity. Chemo-sphere. 81: 781-787.10.1016/j.chemosphere.2010.07.00520684975
    Search in Google Scholar
  37. Neiva TJC, Moraes ACR, Schwyzer R, Rocha TRF, Fries DM, Silva AM, Bene-detti AL. (2010). In vitro ef ect of the herbicide glyphosate on human blood platelet aggregation and coagulation. Rev. Bras. Hematol. Hemoter. 32(4): 291-294.
    Search in Google Scholar
  38. Ortiz-Ordoñez E, Uría-Galicia E, Ruiz-Picos RA, Duran AGS, Trejo YH. (2011). Effect of Yerbimat herbicide on lipid peroxidation, catalase activity, and his-tological damage in gills and liver of the freshwater f sh Goodea atripinnis. Arch. Environ. Contam. Toxicol. 1(3): 443-452.
    Search in Google Scholar
  39. Pari L, Murugavel P. (2005). Role of diallyl tetrasulf de in ameliorating the cadmium induced biochemical changes in rats. Envir. Toxicol. Pharmacol. 20: 493-500.
    Search in Google Scholar
  40. Peluso M, Munnia A, Bolognesi C, Parodi S. (1998). 32P-postlabeling detection of DNA adducts in mice treated with the herbicide Roundup. Environ. Mol. Mutagen. 31(1): 55 -59.
    Search in Google Scholar
  41. Pieniazek D, Bukowska B, Duda E. (2004). Comparision of the ef ect of Roundup Ultra 360 SL pesticide and its active compound glyphosate on human erythrocytes. Pest. Biochem. Physiol. 79: 58-63.
    Search in Google Scholar
  42. Prasad S, Srivastava S, Singh M, Shukla Y. (2009). Clastogenic ef ects of glyphosate in bone marrow cells of Swiss albino mice. J. Toxicol. 1-6.
    Search in Google Scholar
  43. Puértolas L, Damásio J, Barata CA, Soares MVM, Narcís P. (2010). Evaluation of side-ef ects of glyphosate mediated control of giant reed (Arundo donax) on the structure and function of a nearby Mediterranean river ecosystem. Environ. Res. 110 (6): 556-564.
    Search in Google Scholar
  44. Sancho E, Cerón JJ, Ferrando MD. (2000). Cholinesterase activity and hema-tological parameters as biomarkers of sublethal molinate exposure in An-guilla anguilla. Ecotoxicol. Environ. Saf. 46: 81-86.
    Search in Google Scholar
  45. Santos JB, Ferreira EA, Kasuya MCM, Silva AA, Procópio SO. (2005). Tolerance of Bradyrhizobium strains to glyphosate formulations. Crop Protect. 24: 543-547.
    Search in Google Scholar
  46. Scandalios JG. (2005). Oxidative stress: molecular perception and transduc-tion of signals triggering antioxidant gene defenses. Braz. J. Med. Biol. Res. 38: 995-1014.
    Search in Google Scholar
  47. Sevgiler Y, Oruç EO, Üner N. (2004). Evaluation of etoxazole toxicity in the liver of Oreochromis niloticus. Pestic. Biochem. Physiol. 78: 1-8.
    Search in Google Scholar
  48. Smith EA, Oehme FW. (1992). The biological activity of glyphosate to plants and animals: a literature review. Vet. Hum. Toxicol. 34(6): 531-43.
    Search in Google Scholar
  49. Williams GM, Kroes R, Munro IC. (2000). Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans. Regul. Toxicol. Pharmacol. 31(2): 117-65.
    Search in Google Scholar
  50. Yousef M I, Salem MH, Ibrahim HZ, Helmi S, Seehy MA, Bertheussen K. (1995). Toxic ef ects of carbofuran and glyphosate on semen characteristics in rabbits. J. Environ. Sci. Health. 30: 513-534.
    Search in Google Scholar
DOI: https://doi.org/10.2478/v10102-012-0022-5 | Journal eISSN: 1337-9569 | Journal ISSN: 1337-6853
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Language: English
Page range: 133 - 140
Published on: Jan 16, 2013
Published by: Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Glyphosate,
Roundup®,
hepatotoxicity,
hematological damage,
oxidative stress
Related subjects:
Medicine,
Clinical medicine,
Pharmacology, toxicology

© 2013 Raquel Jasper, Gabriel Olivo Locatelli, Celso Pilati, Claudriana Locatelli, published by Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine
This work is licensed under the Creative Commons License.

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