Skip to main content
Have a personal or library account? Click to login
Damage of testicular cell macromolecules and reproductive capacity of male rats following co-administration of ethambutol, rifampicin, isoniazid and pyrazinamide Cover

Damage of testicular cell macromolecules and reproductive capacity of male rats following co-administration of ethambutol, rifampicin, isoniazid and pyrazinamide

Open Access
|May 2012

References

  1. Aboul-Ela EI. (1995). Cytogenetic effects of rifampicin in somatic and germinal cells of the mouse.(4): 325-326.
  2. Aitken RJ, De Iuliis GN. (2007). Origins and consequences of DNA damage in male germ cells.(6): 727-733.
  3. Aitken RJ, Koppers AJ. (2011). Apoptosis and DNA damage in human spermatozoa.(1): 36-42.
  4. Anitha B, Sudha S, Gopinath PM(1994). Genotoxicity evaluation of pyrazinamide in mice.1(1-2): 1-5.
  5. Arinaminpathy N, Due C. (2010). Health in financial crises: economic recession and tuberculosis in Central and Eastern Europe.7(52): 1559-1569.
  6. Asole A, Panu R, Palmieri G. (1976). Effects of ethambutol on the seminal epitheliun of the rat and chicken.(12): 846-848.
  7. Bansal AK, Bilaspuri GS. (2011). Impacts of oxidative stress and antioxidants on semen functions.: 1-7.
  8. Bhide SV, Bhalerao EB, Sarode AV, Maro GB. (1984). Mutagenicity and carcinogenicity of mono- and diacetyl hydrazine.(2): 235-240.
  9. Bondarenko LB, Saprykina NA, Kovalenko VM. (2006). Lung and spleen contents of free amino acids after pyrazinamide treatment.: 79-86.
  10. Bondarenko LB, Shayakhmetova GM, Byshovets TF, Kovalenko VM. (2011). Pyrazinamide-mediated changes in rat type I collagen and spermatogenesis indices.: 285-290.
  11. Braun R, Jakel HP, Schoneich J. (1984). Genetic effects of isoniazid and the relationship to in vivo and in vitro biotransformation.(2-3): 61-69.
  12. Burchiel SW, Davis DA, Ray SD et al. (1992). DMBA-induced cytotoxicity in lymphoid and nonlymphoid organs of B6C3F1 mice: relation of cell death to target cell intracellular calcium and DNA damage.113: 126-132.
  13. Chen QI, Cederbaum AI. (1998). Cytotoxicity and apoptosis produced by cytochrome P450 2E1 in Hep G2 cells.53: 638-648.
  14. Clegg ED, Perreault SD, Klinefelger GR. (2001). Assessment of male reproductive toxicity, in(Hayes AW eds), pp. 1263-1300, Taylor & Francis, Philadelphia, PA.
  15. Cooke MS, Evans DM, Dizdaroglu M, Lunec J. (2003). Oxidative DNA damage: mechanisms, mutation, and disease: 1195-1214.
  16. Donate JMB. (2006). Treatment of tuberculosis, in, pp.1-4, MWL Print Group Ltd.
  17. Donnelly ET, Mcclur N, Lewis SE. (2000). Glutathione and hypotaurine in vitro: effects on human sperm motility, DNA integrity and production of reactive oxygen species.(1): 61-68.
  18. Food and Drug Administration [webpage in the Internet]. Guidance for Industry and Reviewers Estimating the Safe Starting Dose in Clinical Trials for Therapeutics in Adult Healthy Volunteers US. of Department of Health and Human Services, FDA, CDER and CBER. Available from:
  19. Hakansson A, Zhivotovskyt B, Orrenius S(1995). Apoptosis induced by a human milk protein.: 8064-8068.
  20. Healy LN, Puta LJ, Recio L. (1999). Expression and distribution of cytochrome P450 2E1 in B6C3F1 mouse liver and testes.(2):199-207.
  21. Hsien YY, Chang CC, Lin CS. (2006). Seminal malondialdehyde concentration but not glutathione peroxidase activity is negatively correlated with seminal concentration and motility.(1): 23-9.
  22. Tyl RW. (2005). In Vivo Models for Male Reproductive Toxicology, in(Costa LG, Hodgson E, Lawrence DA et al. eds) unit 2.2.10, John Wiley & Sons, Inc.
  23. Jones DP. (2008). Radical-free biology of oxidative stress.: C849-C868.
  24. Kovalenko VM, Bagnyukova TV, Sergienko OV(2007). Epigenetic changes in the rat livers induced by pyrazinamide treatment.: 293-299.
  25. Lieber CS. (1997). Cytochrome P-4502E1: Its physiological and patological role.: 517-544.
  26. Lowry OH, Rosebroughch NJ, Farr AL, Randall RJ. (1951). Protein measurement with Folin phenol reagent.: 265-275.
  27. Luberda Z. (2005). The role of glutathione in mammalian gametes.5(1): 5-17.
  28. Madan A, Graham RA, Carrol KM. (2003). Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes.(4): 421-431.
  29. Minamiyama Y, Ichikava H, Takemura S(2010). Generation of reactive oxygen species in sperms of rats as an earlier marker for evaluating the toxicity of endocrine-disrupting chemicals.(12): 1398-1406.
  30. Oropeza-Hernandez LF, Quintanilla-Vega B, Reyes-Mejia RA(2003). Trifluoroacetylated adducts in spermatozoa, testes, liver and plasma and CYP2E1 induction in rats after subchronic inhalatory exposure to halothane.(1): 105-16.
  31. Quintans LN, Castro GD, Castro JA. (2005). Oxidation of ethanol to acetaldehyde and free radicals by rat testicular microsomes.(1): 25-30.
  32. Ray SD, Kamendulis LM, Gurule MW(1993). Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen.(5): 453-463.
  33. Sanocka D, Kurpisz M. (2004). Reactive oxygen species and sperm cells.: 12-26.
  34. Sedlak J, Lindsay R. (1968). Estimation of total, protein-bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent.(1): 192-205.
  35. Stalnaya ID, Gharishvili TG. (1977). Method for malone dialdehyde determination with thiobarbituric acid, in(Orechovich VN eds) pp. 66-68, Medicine, Moscow.
  36. Tasduq SA, Peerzada K, Koul S et al. (2005). Biochemical manifestations of anti-tuberculosis drugs induced hepatotoxicity and the effect of silymarin.31: 132-135.
  37. Ten J, Mendiola J, Torres-Cantero AM(2008). Occupational and lifestyle exposures on male infertility: A Mini Review.: 16-21.
  38. Wang X, Lu Y, Cederbaum AI. (2005). Induction of cytochrome P450 2E1 increases hepatotoxicity caused by Fas agonistic Jo2 antibody in mice.42: 400-410.
  39. World Health Organization [webpage in the Internet]. Reproductive health strategy to accelerate progress towards the attainment of international development goals and targets Global strategy adopted by the 57th World Health Assembly. Available from:
  40. Yue J, Dong G, He C, Chen J(2009). Protective effects of thiopronin against isoniazid-induced hepatotoxicity in rats.(3): 185-191.
  41. Zhivotosky B, Orrenius S. (2001). Detection of DNA Fragmentation in Whole Cells, in(Bonifacino JS, Dasso M, Harford JB, Lippincott-Schwartz J, Yamada KM, eds) unit 18.3.5, John Wiley & Sons, Inc.
DOI: https://doi.org/10.2478/v10102-012-0002-9 | Journal eISSN: 1337-9569 | Journal ISSN: 1337-6853
Language: English
Page range: 9 - 14
Published on: May 11, 2012
Published by: Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine
In partnership with: Paradigm Publishing Services

© 2012 Ganna Shayakhmetova, Larysa Bondarenko, Valentina Kovalenko, published by Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine
This work is licensed under the Creative Commons License.