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Rat cytochromes P450 oxidize 3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone Cover

Rat cytochromes P450 oxidize 3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone

Open Access
|Nov 2010

References

  1. Arlt VM (2005) 3-Nitrobenzanthrone, a potential human cancer hazard in diesel exhaust and urban air pollution: A review of the evidence.: 399-410.
  2. Arlt VM, Bieler CA, Mier W, Wiessler M and Schmeiser HH (2001) DNA adduct formation by the ubiquitous environmental contaminant 3-nitrobenzanthrone in rats determined byP-postlabeling.: 450-454.
  3. Arlt VM, Cole KJ and Phillips DH (2004a) Activation of 3-nitrobenzanthrone and its metabolites to DNA-damaging species in human B-lymphoblastoid MCL-5 cells.: 149-156.
  4. Arlt VM, Glatt HR, Muckel E, Pabel U, Sorg BL, Schmeiser HH and Phillips DH (2002) Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase.: 1937-1945.
  5. Arlt VM, Glatt H, Muckel E, Pabel U, Sorg BL, Seidel A, Frank H, Schmeiser HH and Phillips DH (2003a) Activation of 3-nitrobenzanthrone and its metabolites by human acetyltransferases, sulfotransferases and cytochrome P450 expressed in Chinese hamster V79 cells.583-592.
  6. Arlt VM, Henderson CJ, Wolf CR, Schmeiser HH, Phillips DH and Stiborová M (2006a) Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases.: 220-231.
  7. Arlt VM, Hewer A, Sorg BL, Schmeiser HH, Phillips DH and Stiborová M (2004b) 3-Aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: evidence for activation by cytochrome P450 1A1 and P450 1A2.: 1092-1101.
  8. Arlt VM, Schmeiser HH, Osborne MR, Kawanishi M, Kanno T, Yagi T, Phillips DH and Takamura-Enya T (2006b) Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and Nposition of guanine and at the Nposition of adenine.: 2139-2146.
  9. Arlt VM, Sorg BL, Osborne M, Hewer A, Seidel A, Schmeiser HH and Phillips DH (2003b) DNA adduct formation by the ubiquitous environmental pollutant 3-nitrobenzanthrone and its metabolites in rats.: 107-114.
  10. Arlt VM, Stiborová M, Henderson CJ, Osborne MR, Bieler CA, Frei E, Martínek V, Sopko B, Wolf CR, Schmeiser HH and Phillips DH (2005) The environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols.: 2644-2652.
  11. Arlt VM, Stiborová M, Hewer A, Schmeiser HH and Phillips DH, (2003c) Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome P450 reductase.: 2752-2761.
  12. Arlt, VM, Zhan L, Schmeiser HH, Honma M, Hayashi M, Phillips DH and Suzuki T environmental pollutant 3-nitrobenzanthrone in Muta Mouse.: 186-195.
  13. Bieler CA, Cornelius M, Klein R, Arlt VM, Wiessler M, Phillips DH and Schmeiser HH (2005) DNA adduct formation by the environmental contaminant 3-nitrobenzanthrone after intratracheal instillation in rats.: 833-838.
  14. Bieler CA, Cornelius MG, Stiborova M, Arlt VM, Wiessler M, Phillips DH and Schmeiser HH (2007) Formation and persistence of DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in target and non-target organs after intratracheal instillation in rats.: 1117-1121.
  15. Bieler CA, Wiessler M, Erdinger L, Suzuki H, Enya T and Schmeiser HH (1999) DNA adduct formation from the mutagenic air pollutant 3-nitrobenzanthrone.: 307-311.
  16. Borlak J, Hansen T, Yuan Z, Sikka HC, Kumar S, Schmidbauer S, Frank H, Jacob J and Seidel A (2000) Metabolism and DNA-binding of 3-nitrobenzanthrone in primary rat alveolar type II cells, in human fetal bronchial, rat epithelial and mesenchymal cell lines.: 73-86.
  17. Enya T, Suzuki H, Watanabe T, Hirayama T and Hisamatsu Y (1997) 3-Nitrobenzanthrone, a powerful bacterial mutagen and suspected human carcinogen found in diesel exhausts and airborne particulates.: 2772-2776.
  18. Grabchev I, Moneva I, Betcheva R and Elyashevich G (2002) Colored microporous polyethylene films: effect of porous structure on dye adsorption.: 34-37.
  19. Hansen T, Seidel A and Borlak J (2007) The environmental carcinogen 3-nitrobenzanthrone and its main metabolite 3-aminobenzanthrone Genhance formation of reactive oxygen intermediates in human A549 lung epithelial cells.: 222-234.
  20. Nagy E, Zeisig M, Kawamura K, Hisumatsu Y, Sugeta A, Adachi S and Moller L (2005) DNA-adduct and tumor formations in rats after intratracheal administration of the urban air pollutant 3-nitrobenzanthrone.: 1821-1828.
  21. Rendic S and DiCarlo FJ (1997) Human cytochrome P450 enzymes: A status report summarizing their reactions, substrates, inducers, and inhibitors.: 413-480.
  22. Seidel A, Dahmann D, Krekeler H and Jacob J (2002) Biomonitoring of polycyclic aromatic compounds in the urine of mining workers occupationally exposed to diesel exhaust.: 333-338.
  23. Stiborová M, Dračínská H, Hájková J, Kadeřábková P, Frei E, Schmeiser HH, Souček P, Phillips DH and Arlt VM (2006) The environmental pollutant and carcinogen 3-nitrobenzanthrone and its human metabolite 3-aminobenzanthrone are potent inducers of rat hepatic cytochromes P450 1A1 and -1A2 and NAD(P)H:quinone oxidoreductase.: 1398-1405.
  24. Stiborová M, Dračínská H, Mizerovská J, Frei E, Schmeiser HH, Hudeček J, Hodek P, Phillips DH and Arlt VM 2008 The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity.: 11-22.
  25. Stiborová M, Martínek V, Rýdlová H, Hodek P and Frei E (2002) Sudan I is a potential carcinogen for humans: evidence for its metabolic activation and detoxication by human recombinant cytochrome P450 1A1 and liver microsomes.: 5678-5684.
  26. Svobodová M, Šístková J, Dračínská H, Hudeček J, Hodek P, Schmeiser HH, Arlt VM, Frei E and Stiborová M (2007) Reductive activation of environmental pollutants 3-nitrobenzanthrone and 2-nitrobenzanthrone.: s277-s279.
  27. Sykora J, Mudago V, Hutterer R, Nepras M, Vanerka J, Kapusta P, Fidler V and Hof M (2002) ABA-C-15: A new dye for probing solvent relaxation in phospholipid bilayers.: 9276-9282.
DOI: https://doi.org/10.2478/v10102-010-0031-1 | Journal eISSN: 1337-9569 | Journal ISSN: 1337-6853
Language: English
Page range: 150 - 154
Published on: Nov 1, 2010
Published by: Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine
In partnership with: Paradigm Publishing Services

© 2010 Jana Mizerovská, Helena Dračínská, Volker Arlt, Jiří Hudeček, Petr Hodek, Heinz Schmeiser, Eva Frei, Marie Stiborová, published by Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine
This work is licensed under the Creative Commons License.