Catabolism of hyaluronan: Involvement of transition metals

Ladislav Šoltés; Grigorij Kogan

doi:10.2478/v10102-009-0026-y

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Catabolism of hyaluronan: Involvement of transition metals

Interdisciplinary Toxicology

Volume 2 (2009): Issue 4 (December 2009)

By: Ladislav Šoltés and Grigorij Kogan

Open Access

|Jan 2010

Abstract

One of the very complex structures in the vertebrates is the joint. The main component of the joint is the synovial fluid with its highmolar-mass glycosaminoglycan hyaluronan, which turnover is approximately twelve hours. Since the synovial fluid does not contain any hyaluronidases, the fast hyaluronan catabolism is caused primarily by reductive-oxidative processes.

Eight transition metals - V²³, Mn²⁵, Fe²⁶, Co²⁷, Ni²⁸, Cu²⁹, Zn³⁰, and Mo⁴² - naturally occurring in living organism are essential for the control of various metabolic and signaling pathways. They are also the key elements in catabolism of hyaluronan in the joint.

In this overview, the role of these metals in physiological and pathophysiological catabolism of hyaluronan is described. The participation of these metals in the initiation and propagation of the radical degradation hyaluronan is critically reviewed.

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Articles in this issue

DOI: https://doi.org/10.2478/v10102-009-0026-y | Journal eISSN: 1337-9569 | Journal ISSN: 1337-6853

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Language: English

Page range: 229 - 238

Published on: Jan 6, 2010

Published by: Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

hyaluronan catabolism,

joint,

Related subjects:

Pharmacology, toxicology

© 2010 Ladislav Šoltés, Grigorij Kogan, published by Slovak Academy of Sciences, Institute of Experimental Pharmacology & Toxicology, Centre of Experimental Medicine
This work is licensed under the Creative Commons License.

Volume 2 (2009): Issue 4 (December 2009)