ALU Insertion Polymorphisms in Populations of the South Caucasus

S Litvinov; I Kutuev; B Yunusbayev; R Khusainova; R Valiev; E Khusnutdinova

doi:10.2478/v10034-008-0030-0

Abstract

An analysis of eight Alu insertion loci (ACE, ApoA1, PV92, TPA25, NBC27, NBC102, NBC148 and NBC182) was carried out in three ethnic groups of the South Caucasus (Abkhazians, Armenians and Georgians). Genetic differentiation between these groups (Gst = 1%) was half as much as in European populations and four time less than in populations of Dagestan. Although it was not possible to determine a contribution of Neolithic farmers to the Caucasian gene pool, the principal component analysis showed clear differences between these populations and those of Europe, Siberia and Asia. No evidence of correlation between genetic and linguistic data in our populations was disclosed. However, long-term habitation on common territory has led to common cultural, anthropological and detectable genetic traits.

References

Barbujani G, Whitehead GN, Bertorelle G, Nasidze I. Testing hypotheses on processes of genetic and linguistic change in the Caucasus. Hum Biol 1994; 66(5): 843-864.
Search in Google Scholar
Nasidze I, Stoneking M. Mitochondrial DNA variation and language replacements in the Caucasus. Proc R Soc Lond (Biol) 2001; 268(1472): 1197-1206.10.1098/rspb.2001.1610108872711375109
Search in Google Scholar
Nasidze I, Sarkisian T, Kerimov A, Stoneking M. Testing hypotheses of language replacement in the Caucasus: evidence from the Y chromosome. Hum Genet 2003; 112(3):255-261.10.1007/s00439-002-0874-412596050
Search in Google Scholar
Nasidze I, Risch GM, Robichaux M, Sherry ST, Batzer MA, Stoneking M. Alu insertion polymorphisms and the genetic structure of human populations from the Caucasus. Eur J Hum Genet 2001; 9(4): 267-272.10.1038/sj.ejhg.520061511313770
Search in Google Scholar
Nasidze I, Ling EYS, Quinque D, Dupanloup I, Cordaux R, Rychkov S, Naumova O, Zhukova O, Sarraf-Zadegan N, Naderi GA, Asgary S, Sardas S, Farhud DD, Sarkisian T, Asadov C, Kerimov A, Stoneking M. Mitochondrial DNA and Y-chromosome variation in the Caucasus. Ann Hum Genet 2004; 68(Pt. 3): 205-221.10.1046/j.1529-8817.2004.00092.x15180701
Search in Google Scholar
Bulayeva KB, Davudov OM, Pavlova TA, Kurbanov RM, Bulayev OA, Harpending H. Genetic subdivision of Daghestan ethnic populations. Russ J Genet 2003; 39(1): 68-76. Translated from Genetika 2003; 39(1): 83-92.
Search in Google Scholar
Reguero M, Cadenas AM, Gayden T, Underhill PA, Herrera R.J. Iran: tricontinental nexus for Y-chromosome driven migration. Hum Hered 2006; 61(3): 132-143.10.1159/00009377416770078
Search in Google Scholar
Batzer MA, Deininger PL. Alu repeats and human genomic diversity. Nat Rev Genet 2002; 3(5): 370-379.10.1038/nrg79811988762
Search in Google Scholar
People of the Caucasus. Gardanov BA, Ed. Narody Kavkaza. Moscow: Izdatelstvo Akademii Nauk SSSR, 1962 (in Russian).
Search in Google Scholar
Sambrook J, Fritsch EF, Maniatis T: Molecular Cloning: A Laboratory Manual. Cold Spring Harbor: Cold Spring Harbor Laboratory Press, 1989.
Search in Google Scholar
Watkins WS, Ricker CE, Bamshad MJ, Carroll ML, Nguyen SV, Batzer MA, Harpending HC, Rogers AR, Jorde LB. Patterns of ancestral human diversity: An analysis of Alu-insertion and restriction-site polymorphisms. Am J Hum Genet 2001; 68(3): 738-752.10.1086/318793127448511179020
Search in Google Scholar
StatSoft Inc: STATISTICA (data analysis software system), version 6, 2001; www.statsoft.com
Search in Google Scholar
Nei M, Chesser RK. Estimation of fixation indices and gene diversities. Ann Hum.Genet 1983; 47(Pt. 3): 253-259.10.1111/j.1469-1809.1983.tb00993.x6614868
Search in Google Scholar
Guo S, Thompson E. Performing the exact test of Hardy-Weinberg proportion for multiple alleles. Biometrics 1992; 48(2): 361-372.10.2307/2532296
Search in Google Scholar
Nei M. F-statistics and analysis of gene diversity in subdivided populations. Ann Hum Genet 1977; 41(2): 225-233.10.1111/j.1469-1809.1977.tb01918.x596830
Search in Google Scholar
Watkins WS, Rogers AR, Ostler CT, Wooding S, Bamshad MJ, Brassington A-ME, Carroll ML, Nguyen SV, Walker JA, Prasad BVR, Reddy PG, Das PK, Batzer MA, Jorde LB. Genetic variation among world populations: Inferences from 100 Alu insertion polymorphisms. Genome Res 2003; 13(7): 1607-1618.10.1101/gr.89460340373412805277
Search in Google Scholar
Kutuev I, Khusainova R, Karunas A, Yunusbayev B, Fedorova S, Lebedev Y, Hunsmann G, Khusnutdinova E. From East to West: patterns of genetic diversity of populations living in four Eurasian regions. Hum Hered 2006; 61(1): 1-9.10.1159/00009130916465065
Search in Google Scholar
Yunusbayev B, Kutuev I, Khusainova R, Guseinov G, Khusnutdinova E. Genetic structure of Dagestan populations: a study of 11 Alu insertion polymorphisms. Hum Biol 2006; 78(4): 465-476.10.1353/hub.2006.005917278621
Search in Google Scholar
Osmanov MO. Narody Dagestana (nationalities of Dagestan). Tishkov VA, Cheshko SV, Eds. Moscow: Nauka, 2002; 492-493.
Search in Google Scholar
Bulayeva KB, Jorde L, Watkins S, Ostler C, Pavlova TA, Bulayev OA, Tofanelli S, Paoli G, Harpending H. Ethnogenomic diversity of Caucasus, Daghestan. Am J Hum Biol 2006; 18(5): 610-620.10.1002/ajhb.2053116917895
Search in Google Scholar
Barbujani G, Nasidze IS, Whitehead GN. Genetic diversity in the Caucasus. Hum Biol 1994; 66(4): 639-668.
Search in Google Scholar
Bulayeva K, Jorde LB, Ostler C, Watkins S, Bulayev O, Harpending H. Genetics and population history of Caucasus populations. Hum Biol 2004; 75(6): 837-853.10.1353/hub.2004.000315018034
Search in Google Scholar
Khusainova R, Akhmetova V, Kutuev I, Salimova A, Korshunova T, Lebedev Y, Khusnutdinova E. Genetic structure of the Volga-Ural and Central Asia populations inferred form the data on Alu polymorphism Russ J Genet 2004; 40(4): 443-449.10.1023/B:RUGE.0000024983.75183.8b
Search in Google Scholar

ALU Insertion Polymorphisms in Populations of the South Caucasus

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