Potentiation of electrochemotherapy by intramuscular IL-12 gene electrotransfer in murine sarcoma and carcinoma with different immunogenicity
By: Ales Sedlar, Tanja Dolinsek, Bostjan Markelc, Lara Prosen, Simona Kranjc, Masa Bosnjak, Tanja Blagus, Maja Cemazar and Gregor Sersa
Open Access
|Nov 2012References
- 1. Sersa G, Miklavcic D, Cemazar M, Rudolf Z, Pucihar G, Snoj M. Electrochemotherapy in treatment of tumours.2008;232-40.
- 2. Kranjc S, Tevz G, Kamensek U, Vidic S, Cemazar M, Sersa G. Radiosensitizing effect of electrochemotherapy in a fractionated radiation regimen in radiosensitive murine sarcoma and radioresistant adenocarcinoma tumor model.2009;677-85.
- 3. Edhemovic I, Gadzijev EM, Brecelj E, Miklavcic D, Kos B, Zupanic A, et al. Electrochemotherapy: a new technological approach in treatment of metastases in the liver.2011;475-85.
- 4. Heller R, Gilbert R, Jaroszeski MJ. Clinical trials for solid tumors using electrochemotherapy.2000;137-56.
- 5. Miklavcic D, Snoj M, Zupanic A, Kos B, Cemazar M, Kropivnik M, et al. Towards treatment planning and treatment of deep-seated solid tumors by electrochemotherapy.10
- 6. Sersa G, Stabuc B, Cemazar M, Miklavcic D, Rudolf Z. Electrochemotherapy with cisplatin: clinical experience in malignant melanoma patients.2000;863-7.
- 7. Cutrera J, Torrero M, Shiomitsu K, Mauldin N, Li S. Intratumoral bleomycin and IL-12 electrochemogenetherapy for treating head and neck tumors in dogs.2008;319-25.
- 8. Heller L, Pottinger C, Jaroszeski MJ, Gilbert R, Heller R. In vivo electroporation of plasmids encoding GM-CSF or interleukin-2 into existing B16 melanomas combined with electrochemotherapy induces long-term antitumour immunity.2000;577-83.
- 9. Sersa G, Cemazar M, Menart V, Gaberc-Porekar V, Miklavcic D. Anti-tumor effectiveness of electrochemotherapy with bleomycin is increased by TNFalpha on SA-1 tumors in mice.1997;85-92.
- 10. Torrero M, Li S. Treatment of SCCVII tumors with systemic chemotherapy and Interleukin-12 gene therapy combination.2008;339-49.
- 11. Torrero MN, Henk WG, Li S. Regression of high-grade malignancy in mice by bleomycin and interleukin-12 electrochemogenetherapy.2006;257-63.
- 12. Mir LM, Roth C, Orlowski S, Quintin-Colonna F, Fradelizi D, Belehradek J, Jr., et al. Systemic antitumor effects of electrochemotherapy combined with histoincompatible cells secreting interleukin-2.1995;30-8.
- 13. Kishida T, Asada H, Itokawa Y, Yasutomi K, Shin-Ya M, Gojo S, et al. Electrochemo-gene therapy of cancer: intratumoral delivery of interleukin-12 gene and bleomycin synergistically induced therapeutic immunity and suppressed subcutaneous and metastatic melanomas in mice.2003;738-45.
- 14. Orlowski S, An D, Belehradek J, Jr., Mir LM. Antimetastatic effects of electrochemotherapy and of histoincompatible interleukin-2-secreting cells in the murine Lewis lung tumor.1998;551-6.
- 15. Ramirez LH, Orlowski S, An D, Bindoula G, Dzodic R, Ardouin P, et al. Electrochemotherapy on liver tumours in rabbits.1998;2104-11.
- 16. Andersen MH, Gehl J, Reker S, Geertsen P, Becker JC, thor Stratem P. Concomitant administration of interleukin-2 during therapeutic vaccinations against cancer: the good, the bad, or the evil?2005;5265-7.
- 17. Mir LM, Orlowski S, Poddevin B, Belehradek J, Jr. Electrochemotherapy tumor treatment is improved by interleukin-2 stimulation of the host’s defenses.1992;331-4.
- 18. Andersen MH, Gehl J, Reker S, Pedersen LO, Becker JC, Geertsen P, et al. Dynamic changes of specific T cell responses to melanoma correlate with IL-2 administration.2003;449-59.
- 19. Cemazar M, Sersa G, Pavlin D, Tozon N. Intramuscular IL-12 Electrogene Therapy for Treatment of Spontaneous Canine Tumors. In: You Y, editor.. InTech; 2011. p. 299 - 320.
- 20. Cemazar M, Jarm T, Sersa G. Cancer electrogene therapy with interleukin-12.2010;300-11.
- 21. Leonard JP, Sherman ML, Fisher GL, Buchanan LJ, Larsen G, Atkins MB, et al. Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production.1997;2541-8.
- 22. Kang WK, Park C, Yoon HL, Kim WS, Yoon SS, Lee MH, et al. Interleukin 12 gene therapy of cancer by peritumoral injection of transduced autologous fibroblasts: outcome of a phase I study.2001;671-84.
- 23. Mazzolini G, Prieto J, Melero I. Gene therapy of cancer with interleukin-12.2003;1981-91.
- 24. Prijic S, Prosen L, Cemazar M, Scancar J, Romih R, Lavrencak J, et al. Surface modified magnetic nanoparticles for immuno-gene therapy of murine mammary adenocarcinoma.2012;4379-91.
- 25. Sangro B, Melero I, Qian C, Prieto J. Gene therapy of cancer based on interleukin 12.2005;573-81.
- 26. Daud AI, DeConti RC, Andrews S, Urbas P, Riker AI, Sondak VK, et al. Phase I trial of interleukin-12 plasmid electroporation in patients with metastatic melanoma.2008;5896-903.
- 27. Heller LC, Heller R. Electroporation gene therapy preclinical and clinical trials for melanoma.2010;312-7.
- 28. Teissie J, Escoffre JM, Paganin A, Chabot S, Bellard E, Wasungu L, et al. Drug delivery by electropulsation: Recent developments in oncology.2012;3-6.
- 29. Pavlin D, Cemazar M, Coer A, Sersa G, Pogacnik A, Tozon N. Electrogene therapy with interleukin-12 in canine mast cell tumors.2011;31-9.
- 30. Markelc B, Bellard E, Sersa G, Pelofy S, Teissie J, Coer A, et al. In vivo molecular imaging and histological analysis of changes induced by electric pulses used for plasmid DNA electrotransfer to the skin: A study in a dorsal window chamber in mice.2012;545-54.
- 31. Rebersek M, Cufer T, Cemazar M, Kranjc S, Sersa G. Electrochemotherapy with cisplatin of cutaneous tumor lesions in breast cancer.2004;593-7.
- 32. Sersa G, Stabuc B, Cemazar M, Jancar B, Miklavcic D, Rudolf Z. Electrochemotherapy with cisplatin: potentiation of local cisplatin antitumour effectiveness by application of electric pulses in cancer patients.1998;1213-8.
- 33. Sersa G, Stabuc B, Cemazar M, Miklavcic D, Rudolf Z. Electrochemotherapy with cisplatin: the systemic antitumour effectiveness of cisplatin can be potentiated locally by the application of electric pulses in the treatment of malignant melanoma skin metastases.2000;381-5.
- 34. Tamzali Y, Borde L, Rols MP, Golzio M, Lyazrhi F, Teissie J. Successful treatment of equine sarcoids with cisplatin electrochemotherapy: a retrospective study of 48 cases.2012;214-20.
- 35. Spugnini EP, Vincenzi B, Citro G, Dotsinsky I, Mudrov T, Baldi A. Evaluation of Cisplatin as an electrochemotherapy agent for the treatment of incompletely excised mast cell tumors in dogs.2011;407-11.
- 36. Tozon N, Sersa G, Cemazar M. Electrochemotherapy: potentiation of local antitumour effectiveness of cisplatin in dogs and cats.2001;2483-8.
- 37. Cemazar M, Pavlin D, Sersa G, Tozon N.In: Proceedings of the Fundamental & Applied Bioelectrics, 23-27th 2012 Norfolk, USA: an international scientific workshop. Norfolk: Old Dominion University, 2012, 94-9.
- 38. Nanni P, de Giovanni C, Lollini PL, Nicoletti G, Prodi G. TS/A: a new metastasizing cell line from a BALB/c spontaneous mammary adenocarcinoma.1983;373-80.
- 39. North RJ, Neubauer RH, Huang JJ, Newton RC, Loveless SE. Interleukin 1-induced, T cell-mediated regression of immunogenic murine tumors. Requirement for an adequate level of already acquired host concomitant immunity.1988;2031-43.
- 40. Rakhmilevich AL, Janssen K, Hao ZL, Sondel PM, Yang NS. Interleukin-12 gene therapy of a weakly immunogenic mouse mammary carcinoma results in reduction of spontaneous lung metastases via a T-cell-independent mechanism.2000;826-38.
- 41. Oshikawa K, Shi FS, Rakhmilevich AL, Sondel PM, Mahvi DM, Yang NS. Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1 beta converting enzyme cDNA.1999;13351-6.
- 42. Di Carlo E, Cappello P, Sorrentino C, D’Antuono T, Pellicciotta A, Giovarelli M, et al. Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway.2005;82-91.
- 43. Allione A, Consalvo M, Nanni P, Lollini PL, Cavallo F, Giovarelli M, et al. Immunizing and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with interleukin (IL)-2, IL-4, IL-6, IL-7, IL-10, tumor necrosis factor alpha, granulocyte-macrophage colony-stimulating factor, and gamma-interferon gene or admixed with conventional adjuvants.1994;6022-6.
- 44. Sersa G, Krzic M, Sentjurc M, Ivanusa T, Beravs K, Kotnik V, et al. Reduced blood flow and oxygenation in SA-1 tumours after electrochemotherapy with cisplatin.2002;1047-54.
- 45. Marty M, Sersa G, Garbay J, Gehl J, Collins C, Snoj M, et al. Electrochemotherapy - An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study.2006;3-13.
- 46. Cemazar M, Milacic R, Miklavcic D, Dolzan V, Sersa G. Intratumoral cisplatin administration in electrochemotherapy: antitumor effectiveness, sequence dependence and platinum content.1998;525-30.
- 47. Tevz G, Pavlin D, Kamensek U, Kranjc S, Mesojednik S, Coer A, et al. Gene electrotransfer into murine skeletal muscle: a systematic analysis of parameters for long-term gene expression.2008;91-101.
- 48. Tevz G, Kranjc S, Cemazar M, Kamensek U, Coer A, Krzan M, et al. Controlled systemic release of interleukin-12 after gene electrotransfer to muscle for cancer gene therapy alone or in combination with ionizing radiation in murine sarcomas.2009;1125-37.
- 49. Corbett TH, Valeriote FA. Rodent models in experimental chemotherapy. In: Kallman RF, editor.. New York: Pergamon Press; 1987. p. 233-47.
- 50. Sersa G, Cufer T, Paulin SM, Cemazar M, Snoj M. Electrochemotherapy of chest wall breast cancer recurrence.2012;379-86.
- 51. Cemazar M, Miklavcic D, Sersa G. Intrinsic sensitivity of tumor cells to bleomycin as an indicator of tumor response to electrochemotherapy.1998;328-33.
- 52. Sersa G, Cemazar M, Miklavcic D. Antitumor effectiveness of electrochemotherapy with cis-diamminedichloroplatinum(II) in mice.1995;3450-5.
- 53. Mali B, Jarm T, Snoj M, Sersa G, Miklavcic D. Antitumor effectiveness of electrochemotherapy: a systematic review and meta-analysis.2012, http://dx.doi.org/10.1016/j.ejso.2012.08.016;
- 54. Sersa G, Kotnik V, Cemazar M, Miklavcic D, Kotnik A. Electrochemotherapy with bleomycin in SA-1 tumor-bearing mice--natural resistance and immune responsiveness.1996;785-91.
- 55. Sersa G, Cemazar M, Miklavcic D, Mir LM. Electrochemotherapy: variable anti-tumor effect on different tumor models.1994;83-7.
- 56. Sersa G, Miklavcic D, Cemazar M, Belehradek J, Jr., Jarm T, Mir LM. Electrochemotherapy with CDDP on LPB sarcoma: comparison of the anti-tumor effectiveness in immunocompetent and immunodeficient mice.1997;279-83.
- 57. Cemazar M, Miklavcic D, Mir LM, Belehradek J, Jr., Bonnay M, Fourcault D, et al. Electrochemotherapy of tumours resistant to cisplatin: a study in a murine tumour model.2001;1166-72.
- 58. Orlowski S, Belehradek J, Jr., Paoletti C, Mir LM. Transient electropermeabilization of cells in culture. Increase of the cytotoxicity of anticancer drugs.1988;4727-33.
- 59. Sersa G, Jarm T, Kotnik T, Coer A, Podkrajsek M, Sentjurc M, et al. Vascular disrupting action of electroporation and electrochemotherapy with bleomycin in murine sarcoma.2008;388-98.
- 60. Corovic S, Mir LM, Miklavcic D. In vivo muscle electroporation threshold determination: realistic numerical models and in vivo experiments.2012;509-20..
- 61. Quaglino P, Osella-Abate S, Marenco F, Nardo T, Gado C, Novelli M, et al. FoxP3 expression on melanoma cells is related to early visceral spreading in melanoma patients treated by electrochemotherapy.2011;734-6.
- 62. Mir LM, Roth C, Orlowski S, Belehradek J, Jr., Fradelizi D, Paoletti C, et al. [Potentiation of the antitumoral effect of electrochemotherapy by immunotherapy with allogeneic cells producing interleukin 2].1992;539-44.
Language: English
Page range: 302 - 311
Submitted on: Jul 21, 2012
Accepted on: Aug 15, 2012
Published on: Nov 9, 2012
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
Related subjects:
© 2012 Ales Sedlar, Tanja Dolinsek, Bostjan Markelc, Lara Prosen, Simona Kranjc, Masa Bosnjak, Tanja Blagus, Maja Cemazar, Gregor Sersa, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons License.