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Contrasting effect of recombinant human erythropoietin on breast cancer cell response to cisplatin induced cytotoxicity Cover

Contrasting effect of recombinant human erythropoietin on breast cancer cell response to cisplatin induced cytotoxicity

Open Access
|Jun 2012

References

  1. Sytkowski JA. Erythropoietin: Blood, Brain and Beyond. Boston: Wiley-VCH; 2004.10.1002/3527602380
  2. Jelkmann W, Wagner K. Beneficial and ominous aspects of the pleiotropic action of erythropoietin. Ann Hematol 2004; 83: 673-86.10.1007/s00277-004-0911-6
  3. Debeljak N, Sytkowski AJ. Erythropoietin: new approaches to improved molecular designs and therapeutic alternatives. Curr Pharm Des 2008; 14: 1302-10.10.2174/138161208799316393
  4. Lacombe C, Mayeux P. The molecular biology of erythropoietin. Nephrol Dial Transplant 1999; 14: 22-8.10.1093/ndt/14.suppl_2.22
  5. Sytkowski AJ. The neurobiology of erythropoietin. Cell Mol Neurobiol 2011; 31: 931-7.10.1007/s10571-011-9695-0
  6. Jelkmann W, Bohlius J, Hallek M, Sytkowski AJ. The erythropoietin receptor in normal and cancer tissues. Crit Rev Oncol Hemat 2008; 67: 39-61.10.1016/j.critrevonc.2008.03.006
  7. Debeljak N, Sytkowski AJ. EpoR. UCSD-Nature Molecule Pages 2007. (doi: 10.1038/mp.a000863.01)
  8. Arcasoy MO. The non-haematopoietic biological effects of erythropoietin. Br J Haematol 2008; 141: 14-31.10.1111/j.1365-2141.2008.07014.x
  9. Vaupel P, Thews O, Hoeckel M. Treatment resistance of solid tumors: role of hypoxia and anemia. Med Oncol 2001; 18: 243-59.10.1385/MO:18:4:243
  10. Chang J, Couture F, Young S, McWatters KL, Lau CY. Weekly epoetin alfa maintains hemoglobin, improves quality of life, and reduces transfusion in breast cancer patients receiving chemotherapy. J Clin Oncol 2005; 23: 2597-605.10.1200/JCO.2004.12.027
  11. Velenik V, Oblak I, Kodre V. Managing anemia with epoetin alfa in patients with rectal cancer. Radiol Oncol 2005; 39: 133-40.
  12. Henke M, Laszig R, Rube C, Schafer U, Haase KD, Schilcher B, et al. Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. Lancet 2003; 362: 1255-60.10.1016/S0140-6736(03)14567-9
  13. Leyland-Jones B. Breast cancer trial with erythropoietin terminated unexpectedly. Lancet Oncol 2003; 4: 459-60.10.1016/S1470-2045(03)01163-X
  14. Leyland-Jones B, Semiglazov V, Pawlicki M, Pienkowski T, Tjulandin S, Manikhas G, et al. Maintaining normal hemoglobin levels with epoetin alfa in mainly nonanemic patients with metastatic breast cancer receiving first-line chemotherapy: a survival study. J Clin Oncol 2005; 23: 5960-72.10.1200/JCO.2005.06.150
  15. Bohlius J, Schmidlin K, Brillant C, Schwarzer G, Trelle S, Seidenfeld J, et al. Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials. Lancet 2009; 373: 1532-42.10.1016/S0140-6736(09)60502-X
  16. Glaspy J, Crawford J, Vansteenkiste J, Henry D, Rao S, Bowers P, et al. Erythropoiesis-stimulating agents in oncology: a study-level meta-analysis of survival and other safety outcomes. Br J Cancer 2010; 102: 301-15.10.1038/sj.bjc.6605498281666220051958
  17. Ludwig H, Crawford J, Osterborg A, Vansteenkiste J, Henry DH, Fleishman A, et al. Pooled analysis of individual patient-level data from all randomized, double-blind, placebo-controlled trials of darbepoetin alfa in the treatment of patients with chemotherapy-induced anemia. J Clin Oncol 2009; 27: 2838-47.10.1200/JCO.2008.19.113019380447
  18. Tonelli M, Hemmelgarn B, Reiman T, Manns B, Reaume MN, Lloyd A, et al. Benefits and harms of erythropoiesis-stimulating agents for anemia related to cancer: a meta-analysis. CMAJ 2009; 180: E62-71.10.1503/cmaj.090470268321019407261
  19. Sytkowski AJ. Does erythropoietin have a dark side? Epo signaling and cancer cells. Sci STKE 2007; 2007: pe38.10.1126/stke.3952007pe3817636183
  20. Fodor J, Major T, Tóth J, Sulyok Z, Polgár C. Comparison of mastectomy with breast-conserving surgery in invasive lobular carcinoma: 15-Year results. Rep Pract Oncol Radiother. 2011; 16: 227-31.10.1016/j.rpor.2011.06.005386321524376985
  21. Lekic M, Kovac V, Triller N, Knez L, Sadikov A, Cufer1 T. Outcome of small cell lung cancer (SCLC) patients with brain metastases in a routine clinical setting. Radiol Oncol 2012; 46(3): 213-225.; 46: 54-9.10.2478/v10019-012-0007-1342376622933980
  22. Małecki K, Gliński B, Mucha-Małecka A, Ryś J, Kruczak A, Roszkowski K, et al. Prognostic and predictive significance of p53, EGFr, Ki-67 in larynx preservation treatment. Rep Pract Oncol Radiother. 2010; 15: 87-92.10.1016/j.rpor.2010.06.001386320224376930
  23. Kovač V, Smrdel U. Meta-analyses of clinical trials in patients with non-small cell lung cancer. Neoplasma 2004; 51: 334-40.
  24. Martin M. Platinum compounds in the treatment of advanced breast cancer. Clin Breast Cancer 2001; 2: 190-208.10.3816/CBC.2001.n.02211899413
  25. Todorovic V, Sersa G, Flisar K, Cemazar M. Enhanced cytotoxicity of bleomycin and cisplatin after electroporation in murine colorectal carcinoma cells. Radiol Oncol 2009; 43: 264-73.10.2478/v10019-009-0037-5
  26. Erčulj N, Kovač V, Hmeljak J, Dolžan V. The influence of platinum pathway polymorphisms on the outcome in patients with malignant mesothelioma. Ann Oncol 2012; 23: 961-7.10.1093/annonc/mdr32421765044
  27. Siddik ZH. Cisplatin: mode of cytotoxic action and molecular basis of resistance. Oncogene 2003; 22: 7265-79.10.1038/sj.onc.120693314576837
  28. Acs G, Acs P, Beckwith SM, Pitts RL, Clements E, Wong K, et al. Erythropoietin and erythropoietin receptor expression in human cancer. Cancer Res 2001; 61: 3561-5.
  29. Cui X, Schiff R, Arpino G, Osborne CK, Lee AV. Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy. J Clin Oncol 2005; 23: 7721-35.10.1200/JCO.2005.09.00416234531
  30. Larsson AM, Jirstrom K, Fredlund E, Nilsson S, Ryden L, Landberg G, et al. Erythropoietin receptor expression and correlation to tamoxifen response and prognosis in breast cancer. Clin Cancer Res 2009; 15: 5552-9.10.1158/1078-0432.CCR-08-301419706814
  31. Belenkov AI, Shenouda G, Rizhevskaya E, Cournoyer D, Belzile JP, Souhami L, et al. Erythropoietin induces cancer cell resistance to ionizing radiation and to cisplatin. Mol Cancer Ther 2004; 3: 1525-32.10.1158/1535-7163.1525.3.12
  32. Kumar SM, Zhang G, Bastian BC, Arcasoy MO, Karande P, Pushparajan A, et al. Erythropoietin receptor contributes to melanoma cell survival in vivo. Oncogene 2011.10.1038/onc.2011.366344183121860424
  33. Li J, Vesey DA, Johnson DW, Gobe G. Erythropoietin reduces cisplatin-induced apoptosis in renal carcinoma cells via a PKC dependent pathway. Cancer Biol Ther 2007; 6: 1944-50.10.4161/cbt.6.12.497518075299
  34. Palumbo C, Battisti S, Carbone D, Albonici L, Alimandi M, Bei R, et al. Recombinant erythropoietin differently af fects proliferation of mesothelioma cells but not sensitivity to cisplatin and pemetrexed. Cancer Chemother Pharmacol 2008; 61: 893-901.10.1007/s00280-007-0608-317922127
  35. Shi Z, Hodges VM, Dunlop EA, Percy MJ, Maxwell AP, El-Tanani M, et al. Erythropoietin-induced activation of the JAK2/STAT5, PI3K/Akt, and Ras/ERK pathways promotes malignant cell behavior in a modified breast cancer cell line. Molecular cancer research : MCR 2010; 8: 615-26.10.1158/1541-7786.MCR-09-026420353997
  36. Hayakawa J, Ohmichi M, Kurachi H, Kanda Y, Hisamoto K, Nishio Y, et al. Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin. Cancer Res 2000; 60: 5988-94.
  37. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3: RESEARCH0034.10.1186/gb-2002-3-7-research0034
  38. Bustin SA, Benes V, Garson JA, Hellemans J, Huggett J, Kubista M, et al. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 2009; 55: 611-22.10.1373/clinchem.2008.112797
  39. Kutuk O, Arisan ED, Tezil T, Shoshan MC, Basaga H. Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation. Carcinogenesis 2009; 30: 1517-27.10.1093/carcin/bgp165
  40. Abramoff MD, Magelhaes PJ, Ram SJ. Image Processing with ImageJ. Biophotonics International 2004; 11: 36-42.
  41. Smyth GK. Limma: linear models for microarray data. In: Robert Gentleman VJC, Wolfgang Huber, Rafael A. Irizarry, Sandrine Dudoit editor. Bioinformatics and Computational Biology Solutions Using R and Bioconductor. New York: Springer; 2005. p. 397-420.10.1007/0-387-29362-0_23
  42. (2008) RDCT. R: A language and environment for statistical computing. Vienna: R Fundation for Statistical Computing; 2011.
  43. Benjamini Y, Hochberg Y. Controlling the False Discovery Rate - a Practical and Powerful Approach to Multiple Testing. R Stat Soc Series B Stat Methodol 1995; 57: 289-300.10.1111/j.2517-6161.1995.tb02031.x
  44. Zager V, Cemazar M, Hreljac I, Lah TT, Sersa G, Filipic M. Development of human cell biosensor system for genotoxicity detection based on DNA damage-induced gene expression. Radiol Oncol 2010; 44: 42-51.10.2478/v10019-010-0010-3
  45. Henkels KM, Turchi JJ. Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines. Cancer Res 1999; 59: 3077-83.
  46. Yamashita H, Nevalainen MT, Xu J, LeBaron MJ, Wagner KU, Erwin RA, et al. Role of serine phosphorylation of Stat5a in prolactin-stimulated beta-casein gene expression. Mol Cell Endocrinol 2001; 183: 151-63.10.1016/S0303-7207(01)00546-9
  47. Lu CH, Shen Q, DuPre E, Kim H, Hilsenbeck S, Brown PH. cFos is critical for MCF-7 breast cancer cell growth. Oncogene 2005; 24: 6516-24.10.1038/sj.onc.1208905
  48. Perkins ND. Achieving transcriptional specificity with NF-kappa B. Int J Biochem Cell B 1997; 29: 1433-48.10.1016/S1357-2725(97)00088-5
  49. Patel HR, Sytkowski AJ. Erythropoietin activation of AP1 (Fos/Jun). Exp Hematol 1995; 23: 619-25.
  50. Mariggio S, Bavec A, Natale E, Zizza P, Salmona M, Corda D, et al. Galpha13 mediates activation of the cytosolic phospholipase A2alpha through fine regulation of ERK phosphorylation. Cellular signalling 2006; 18: 2200-8.10.1016/j.cellsig.2006.05.00316806823
  51. Schnellmann RG, Zhuang SG. A death-promoting role for extracellular signal-regulated kinase. J Pharmacol Exp Ther 2006; 319: 991-7.10.1124/jpet.106.10736716801453
  52. Marone R, Cmiljanovic V, Giese B, Wymann MP. Targeting phosphoinositide 3-kinase: moving towards therapy. Biochim Biophys Acta 2008; 1784: 159-85.10.1016/j.bbapap.2007.10.00317997386
  53. Gewirtz DA, Di X, Walker TD, Sawyer ST. Erythropoietin fails to interfere with the antiproliferative and cytotoxic effects of antitumor drugs. Clin Cancer Res 2006; 12: 2232-8.10.1158/1078-0432.CCR-05-228716609039
  54. Sigounas G, Sallah S, Sigounas VY. Erythropoietin modulates the anticancer activity of chemotherapeutic drugs in a murine lung cancer model. Cancer Lett 2004; 214: 171-9.10.1016/j.canlet.2004.06.00915363543
  55. Zhang L, Yu J. PUMA, a potent killer with or without p53. Oncogene 2008; 27: S71-S83.10.1038/onc.2009.45286043219641508
  56. Pelekanou V, Kampa M, Kafousi M, Dambaki K, Darivianaki K, Vrekoussis T, et al. Erythropoietin and its receptor in breast cancer: correlation with steroid receptors and outcome. Cancer Epidemiol Biomarkers Prev 2007; 16: 2016-23.10.1158/1055-9965.EPI-06-102317932349
  57. Pelekanou V, Notas G, Sanidas E, Tsapis A, Castanas E, Kampa M. Testosterone membrane-initiated action in breast cancer cells: Interaction with the androgen signaling pathway and EPOR. Molec Oncol 2010; 4: 135-49.10.1016/j.molonc.2010.01.004552789220189893
  58. Notas G, Kampa M, Pelekanou V, Castanas E. Interplay of estrogen receptors and GPR30 for the regulation of early membrane initiated transcriptional effects: A pharmacological approach. Steroids 2011.10.1016/j.steroids.2011.11.00522138208
DOI: https://doi.org/10.2478/v10019-012-0037-8 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Language: English
Page range: 213 - 225
Published on: Jun 19, 2012
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year

© 2012 Nina Trost, Peter Juvan, Gregor Sersa, Natasa Debeljak, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons License.

Volume 46 (2012): Issue 3 (September 2012)