Usefulness of f-18 FDG PET/CT in subcutaneous panniculitis-like t cell lymphoma: disease extent and treatment response evaluation

Kim, Jin-Suk; Jeong, Young Jin; Sohn, Myung-Hee; Jeong, Hwan-Jeong; Lim, Seok Tae; Kim, Dong Wook; Kwak, Jae-Yong; Yim, Chang-Yeol

doi:10.2478/v10019-012-0017-z

Abstract

Background. Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare form of cutaneous lymphomas, accounting for less than 1% of cases of non-Hodgkin’s lymphoma. Fluorine-18 fluorodeoxyglucose (F-18 FDG) positronemission tomography/computed tomography (PET/CT) findings of SPTCL before and after treatment were rarely reported.

Case report. We report a case of SPTCL in which F-18 FDG PET/CT showed increased FDG accumulations in numerous subcutaneous nodules without extracutaneous disease. Contrast-enhanced CT during F-18 FDG PET/CT showed multiple minimally enhancing nodules with an infiltrative pattern in the subcutaneous layer throughout the body. Follow-up F-18 FDG PET/CT after three cycles of CHOP chemotherapy showed a complete metabolic remission of the lesions.

Conclusions. F-18 FDG PET/CT is suggested to be useful in assessing the disease activity, extent and treatment response in SPTCL.

References

1. Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, et al. WHOEORTC classification for cutaneous lymphomas. Blood 2005; 105: 3768-85.10.1182/blood-2004-09-350215692063
Search in Google Scholar
2. Gonzalez CL, Medeiros LJ, Braziel RM, Jaffe ES. T-cell lymphoma involving subcutaneous tissue: a clinicopathologic entity commonly associated with hemophagocytic syndrome. Am J Surg Pathol 1991; 15: 17-27.10.1097/00000478-199101000-000021985499
Search in Google Scholar
3. Horvat M, Jezersek Novakovic B. Effect of response quality and line of treatment with rituximab on overall and disease-free survival of patients with B-cell lymphoma. Radiol Oncol 2010; 44: 232-8.10.2478/v10019-010-0044-6342370322933921
Search in Google Scholar
4. Salhany KE, Macon WR, Choi JK, Elenitsas R, Lessin SR, Felgar RE, et al. Subcutaneous panniculitis-like T-cell lymphoma: clinicopathologic, immunophenotypic, and genotypic analysis of alpha/beta and gamma/delta subtypes. Am J Surg Pathol 1998; 22: 881-93.10.1097/00000478-199807000-000109669350
Search in Google Scholar
5. Paulli M, Berti E. Cutaneous T-cell lymphomas (including rare subtypes): current concepts II. Haematologica 2004; 89:1371-2.
Search in Google Scholar
6. Willemze R, Jansen PM, Cerroni L, Berti E, Santucci M, Assaf C, et al. Subcutaneous panniculitis-like T-cell lymphoma: definition, classification, and prognostic factors: an EORTC Cutaneous Lymphoma Group Study of 83 cases. Blood 2008; 111: 838-45.10.1182/blood-2007-04-08728817934071
Search in Google Scholar
7. Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL: Harrison’s principles of internal medicine. New York: McGraw-Hill; 2005. p. 654.
Search in Google Scholar
8. Weenig RH, Ng CS, Perniciaro C. Subcutaneous panniculitis-like T-cell lymphoma. Am J Dermatopathol 2001; 23: 206-15.10.1097/00000372-200106000-0000811391101
Search in Google Scholar
9. Hoque SR, Child FJ, Whittaker SJ, Ferreira S, Orchard G, Jenner K, et al. Subcutaneous panniculitis-like T-cell lymphoma: a clinicopathological, immunophenotypic and molecular analysis of six patients. Br J Dermatol 2003; 148: 516-25.10.1046/j.1365-2133.2003.05226.x12653744
Search in Google Scholar
10. Marzano AV, Berti E, Paulli M, Caputo R. Cytophagocytic histiocytic panniculitis and subcutaneous panniculitis-like T-cell lymphoma. Arch Dermatol 2000; 136: 889-96.10.1001/archderm.136.7.88910890991
Search in Google Scholar
11. Perniciaro C, Zalla MJ, White JW Jr, Menke DM. Subcutaneous T-cell lymphoma. Report of two additional cases and further observations. Arch Dermatol. 1993, 129: 1171-6.10.1001/archderm.129.9.11718363403
Search in Google Scholar
12. Takeshita M, Imayama S, Oshiro Y, Kurihara K, Okamoto S, Matsuki Y, et al. Clinicopathologic analysis of 22 cases of subcutaneous panniculitis-like CD56- or CD56+ lymphoma and review of 44 other reported cases. Am J Clin Pathol 2004; 121: 408-16.10.1309/TYRGT196N2APLLR9
Search in Google Scholar
13. Massone C, Chott A, Metze D, Kerl K, Citarella L, Vale E, et al. Subcutaneous, blastic natural killer (NK), NK/T-cell and other cytotoxic lymphomas of the skin: a morphologic, immunophenotypic and molecular study of 50 patients. Am J Surg Pathol 2004; 28: 719-35.10.1097/01.pas.0000126719.71954.4f15166664
Search in Google Scholar
14. Lee HJ, Im JG, Goo JM, Kim KW, Choi BI, Chang KH, et al. Peripheral T-Cell lymphoma: spectrum of imaging findings with clinical and pathologic features. RadioGraphics 2003; 23: 7-26.10.1148/rg.23102501812533636
Search in Google Scholar
15. Kang BS, Choi SH, Cha HJ, Jung YK, Lee JH, Jeong AK, et al. Subcutaneous panniculitis-like T-cell lymphoma: US and CT findings in three patients. Skeletal Radiol 2007; 36: S67-71.10.1007/s00256-006-0173-616909278
Search in Google Scholar
16. Hodolic M. Role of 18F-choline PET/CT in evaluation of patients with prostate carcinoma. Radiol Oncol 2011; 45: 17-21.10.2478/v10019-010-0050-8342371422933929
Search in Google Scholar
17. Huić D, Mutvar A, Kinda-Bašić S, Aurer T, Ciglar1M, Grošev D, et al. Negative predictive value of F-18-FDG coincidence PET in patients with Hodgkin’s disease and a residual mass after therapy: a retrospective diagnostic test study. Radiol Oncol 2009; 43: 258-63.10.2478/v10019-009-0024-x
Search in Google Scholar
18. Jerusalem G, Hustinx R, Beguin Y, Fillet G. Evaluation of therapy for lymphoma. Semin Nucl Med 2005; 35: 186-96.10.1053/j.semnuclmed.2005.02.00416098292
Search in Google Scholar
19. Ravizzini G, Meirelles GS, Horwitz SM, Grewal RK. F-18 FDG uptake in subcutaneous panniculitis-like T-cell lymphoma. Clin Nucl Med 2008; 33: 903-5.10.1097/RLU.0b013e31818bf2c719033805
Search in Google Scholar
20. Kong EJ, Cho IH, Chun KA, Bae YK, Chol JH, Hyun MS. F-18 FDG PET/CT findings of subcutaneous panniculitis-like T-cell lymphoma: a case report. Nucl Med Mol Imaging 2009; 43: 240-4.
Search in Google Scholar
21. Tsai EY, Taur A, Espinosa L, Quon A, Johnson D, Dick S, et al. Staging accuracy in mycosis fungoides and sezary syndrome using integrated positron emission tomography and computed tomography. Arch Dermatol 2006; 142: 577-84.10.1001/archderm.142.5.57716702495
Search in Google Scholar
22. Kuo PH, McClennan BL, Carlson K, Wilson LD, Edelson RL, Heald PW, et al. FDG-PET/CT in the evaluation of cutaneous T-cell lymphoma. Mol Imaging Biol 2008; 10: 74-81.10.1007/s11307-007-0127-y18196347
Search in Google Scholar
23. Rodriguez VR, Joshi A, Peng F, Rabah RM, Stockmann PT, Savaşan S. Positron emission tomography in subcutaneous panniculitis-like T-cell lymphoma. Pediatr Blood Cancer 2009; 52: 406-8.10.1002/pbc.2180518985722
Search in Google Scholar

Usefulness of f-18 FDG PET/CT in subcutaneous panniculitis-like t cell lymphoma: disease extent and treatment response evaluation

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