Prognostic value of immunohistochemical expression of HER-2/neu in patients with lung carcinoma

Biljana Poposka; Snezana Smickova; Simonida Crvenkovska; Beti Ivanovska; Tome Stefanovski; Gordana Petrusevska

doi:10.2478/v10019-008-0014-4

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Prognostic value of immunohistochemical expression of HER-2/neu in patients with lung carcinoma

Radiology and Oncology

Volume 42 (2008): Issue 3 (September 2008)

By: Biljana Poposka, Snezana Smickova, Simonida Crvenkovska, Beti Ivanovska, Tome Stefanovski and Gordana Petrusevska

Open Access

|Sep 2008

Abstract

Background. The amplification and the overexpression of the Her-2/neu gene have been shown in certain human tumours and are postulated to be important in human carcinogenesis. In this study we evaluated the expression of HER-2/neu gene in patients with lung carcinoma (LC) and assessed its prognostic significance.

Patients and methods. HER-2/neu expression was determined in 127 LC patients using immunohistochemistry (IHC) performed on paraffin-embedded section - Hercep Test™ (DAKO).

Results. The overall HER-2/neu expression was seen in 36 (28.35%) of 127 LC patients. According to the histological type, HER-2/neu overexpression was detected in 12 patients with adenocarcinomas (60%), in 19 patients with squamous cell carcinomas (31.14%), in 4 patients with small cell-lung carcinomas (10%) and in 1 patient with other carcinomas (16.66%). Only in patients with small cell-lung carcinomas HER-2/neu overexpression was in correlation with the stage of the disease (p<0.001). The patients with HER-2/neu positive expression were associated with a significantly shorter survival compared with those who were HER-2/neu negative (log rank, p<0.002).

Conclusions. These observations suggest that HER-2/neu positivity may serve as a prognostic indicator in patients with LC. HER-2/neu plays a role in identifying patients at risk for the shortened survival, who may benefit from a more aggressive therapy.

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DOI: https://doi.org/10.2478/v10019-008-0014-4 | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099

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Language: English

Page range: 151 - 158

Published on: Sep 23, 2008

Published by: Association of Radiology and Oncology

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

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© 2008 Biljana Poposka, Snezana Smickova, Simonida Crvenkovska, Beti Ivanovska, Tome Stefanovski, Gordana Petrusevska, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons License.

Volume 42 (2008): Issue 3 (September 2008)