Solid tumors in young children in Moscow Region of Russian Federation

Kachanov, Denis; Dobrenkov, Konstantin; Shamanskaya, Tatyana; Abdullaev, Ruslan; Inushkina, Evgueniya; Savkova, Rimma; Varfolomeeva, Svetlana; Rumyantsev, Alexander

doi:10.2478/v10019-007-0037-2

Abstract

Background. The aim of the study was to assess the main epidemiologic characteristics of solid tumours in young children.

Methods. The data were retrieved from the Childhood Cancer Registry of Moscow Region, Russian Federation. Children aged 0-4 years with solid tumours diagnosed in 2000-2006 were included in the analysis.

Results. The data on total 142 children with solid tumours were analyzed. The average number of annually registered cases was 5.9 ± 1.1 in infants and 14 ± 1.8 in older children with male-to-female ratio 1.1:1 and 0.92:1, respectively. The average incidence rate (IR) of all solid tumours was 10.6 per 100.000 children/year in infants and 7.35 per 100.000 children/year in children 1-4 years old. The prevalent types of solid tumours in infants were hepatic (IR 2.46) and renal (IR 2.26) tumours. In children aged 1-4 years the following IRs for certain malignancies were found: CNS tumours 1.70, renal tumours 1.76, sympathetic nervous system tumours 1.73, retinoblastoma 0.87, soft tissue sarcomas 0.70, germ-cell tumours 0.19, hepatic tumours 0.14, and bone tumours 0.13.

Conclusions. The lower IR of CNS tumours can be explained by under-reporting of this cancer type in Moscow region as a result of patient scattering through non-oncological hospitals. As compared to the data from cancer registries of the most European countries and US, lower IR of sympathetic nervous system tumours and retinoblastoma and higher IR of liver tumours and soft tissue sarcomas in infants were revealed in this study.

References

Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg LX, et al. SEER Cancer Statistics Review, National Cancer Institute, Bethesda, MD. http://seer.cancer.gov/csr/1975-2001 [(eds)]. http://seer.cancer.gov/csr/1975-2001
Search in Google Scholar
Desandes E, Clavel J, Berger C, Bernard JL, Blouin P, de Lumley L, et al. Cancer incidence among children in France, 1990-1999. Pediatr Blood Cancer 2004; 43: 749-57.10.1002/pbc.20148
Search in Google Scholar
Gurney JG, Smith MA, Ross JA. Cancer among infants. In: Ries LAG, Smith MA, Gurney JG, et al, editors. Cancer incidence and survival among children and adolescents: United States SEER Program 1975-1995. Bethesda: National Cancer Institute, SEER Program; 1999. p. 149-56.
Search in Google Scholar
Birch JM, Blair V. The epidemiology of infant cancers. Br J Cancer Suppl 1992; 18: S2-4.
Search in Google Scholar
Kramarova E, Stiller CA. The international classification of childhood cancer. Int J Cancer 1996; 68: 759-65.10.1002/(SICI)1097-0215(19961211)68:6<;759::AID-IJC12>3.0.CO;2-W
Search in Google Scholar
Percy C, van Holten VCM, editors. International classification of childhood cancer. Second edition. Geneva; 1992.
Search in Google Scholar
Kaatsch P, Rickert CH, Kuhl J, Schuz J, Michaelis J. Population-based epidemiologic data on brain tumors in German children. Cancer 2001; 92: 3155-64.10.1002/1097-0142(20011215)92:12<;3155::AID-CNCR10158>3.0.CO;2-C
Search in Google Scholar
Minaev SV. Incidence of childhood cancer in Stavropol territory, Russia. Med Pediatr Oncol 2001; 37:140-1.10.1002/mpo.1184
Search in Google Scholar
Spix C, Pastore G, Sankila R, Stiller CA, Steliarova-Foucher E. Neuroblastoma incidence and survival in European children (1978-1997): report from the Automated Childhood Cancer Information System project. Eur J Cancer 2006; 42: 2081-91.10.1016/j.ejca.2006.05.008
Search in Google Scholar
Dalmasso P, Pastore G, Zuccolo L, Maule MM, Pearce N, Merletti F, et al. Temporal trends in the incidence of childhood leukemia, lymphomas and solid tumors in north-west Italy, 1967-2001. A report of the Childhood Cancer Registry of Piedmont. Haematologica 2005; 90: 1197-204.
Search in Google Scholar
Stiller CA, Pritchard J, Steliarova-Foucher E. Liver cancer in European children: incidence and survival, 1978-1997. Report from the Automated Childhood Cancer Information System project. Eur J Cancer 2006; 42: 2115-23.10.1016/j.ejca.2006.05.011
Search in Google Scholar
MacCarthy A, Draper GJ, Steliarova-Foucher E, Kingston JE. Retinoblastoma incidence and survival in European children (1978-1997). Report from the Automated Childhood Cancer Information System project. Eur J Cancer 2006; 42: 2092-102.10.1016/j.ejca.2006.06.003
Search in Google Scholar
Pastore G, Peris-Bonet R, Carli M, Martinez-Garcia C, Sanchez de Toledo J, Steliarova-Foucher E. Childhood soft tissue sarcomas incidence and survival in European children (1978-1997): report from the Automated Childhood Cancer Information System project. Eur J Cancer 2006; 42: 2136-49.10.1016/j.ejca.2006.05.016
Search in Google Scholar
Pastore G, Znaor A, Spreafico F, Graf N, Pritchard-Jones K, Steliarova-Foucher E. Malignant renal tumours incidence and survival in European children (1978-1997): report from the Automated Childhood Cancer Information System project. Eur J Cancer 2006; 42: 2103-14.10.1016/j.ejca.2006.05.010
Search in Google Scholar
Peris-Bonet R, Martinez-Garcia C, Lacour B, Petrovich S, Giner-Ripoll B, Navajas A, et al. Childhood central nervous system tumours - incidence and survival in Europe (1978-1997): report from Automated Childhood Cancer Information System project. Eur J Cancer 2006; 42: 2064-80.10.1016/j.ejca.2006.05.009
Search in Google Scholar

Solid tumors in young children in Moscow Region of Russian Federation

Abstract

Paradigm

My account