Skip to main content
Have a personal or library account? Click to login
Subchronic exposure of rats to sublethal dose of microcystin-YR induces DNA damage in multiple organs Cover

Subchronic exposure of rats to sublethal dose of microcystin-YR induces DNA damage in multiple organs

Radiology and Oncology
Volume 41 (2007): Issue 1 (March 2007)
By: ,  ,  ,  ,   and    
Open Access
|Apr 2007
References

References

  1. McElhiney J, Lawton LA. Detection of the cyano-bacterial hepatotoxins microcystins.2005;: 219-30.
    Open DOISearch in Google Scholar
  2. Dawson RM. Toxicology of microcystins.1998;: 953-62.
    Open DOISearch in Google Scholar
  3. Sedmak B, Kosi, G. Microcystins in Slovene fresh-waters (Central Europe): first report.1997;: 64-73.
    Open DOISearch in Google Scholar
  4. Codd GA, Bell SG, Kaya K, Ward CJ, Beattie KA, Metcalf JS. Cyanobacterial toxins, exposure routes and human health.1999;: 405-15.
    Open DOISearch in Google Scholar
  5. Carmichael WW. Azevedo SMFO, An JS, Molica RJR, Jochimsen EM, Lau S, et al. Human fatalities from cyanobacteria: Chemical and biological evidence for cyanotoxins.2001;: 663-8.
    Open DOISearch in Google Scholar
  6. Ueno Y, Nagata S, Tsutsumi T, Hasegawa A, Watanabe M.F, Park HD, et al. Detection of micro-cystins, a blue-green algal hepatotoxin, in drinking water sampled in Haimen and Fusui, endemic areas of primary liver cancer in China, by highly sensitive immunoassay.1996;: 1317-21.
    Open DOISearch in Google Scholar
  7. Nishiwaki R, Ohta T, Suoeka E, Suganuma M, Harada KI, Watanebae MF, et al. Two significant aspect of microcystin-LR: specific binding and liver specificity.1994;: 283-9.
    Open DOISearch in Google Scholar
  8. Ito E, Kondo F, Harada KI. First report on the distribution of orally administered microcystin-LR in mouse tissue using an immunostaining method.2000;: 37-48.
    Open DOISearch in Google Scholar
  9. Eriksson JE, Gronberg L, Nygård S, Slotte JP, Meriluoto JA. Hepatocellular uptake of 3H-dihydromicrocystin-LR, a cyclic peptide toxin.1990;: 60-6.
    Open DOISearch in Google Scholar
  10. Carmichael WW, Falconer IR. Diseases related to freshwater blue-green algal toxins and control measures. In: Falconer IR, editor.. London: Academic Press; 1993. p. 187-209.
    Open DOISearch in Google Scholar
  11. Chong MW, Gu KD, Lam PK, Yang M, Fong WF. Study on the cytotoxicity of microcystin-LR on cultured cells.2000;: 143-7.
    Open DOISearch in Google Scholar
  12. McDermott CM, Nho CW, Howard W, Holton B. The cyanobacterial toxin, microcysin-LR can induce apoptosis in a variety of cell types.1998;: 1981-6.
    Open DOISearch in Google Scholar
  13. Carmichael WW, Azevedo SM, An JS, Molica RJ, Jochimsen EM, Lau S, Rinehart KL, Shaw GR, Eaglesham GK. Human fatalities from cyanobacteria: chemical and biological evidence for cyanotoxins.2001;: 663-8.
    Open DOISearch in Google Scholar
  14. Yoshizawa S, Matsushima R, Watanabe MF, Harada K-I, Ichihara A, Carmichael WW, Fujiki H. Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity.1990;: 609-14.
    Open DOISearch in Google Scholar
  15. Ding W-X, Shen H-M, Ong C-N. Critical role of reactive oxygen species and mitochondrial permeability transition in microcystin-induced rapid apoptosis in rat hepatocytes.2000;: 547-55.
    Open DOISearch in Google Scholar
  16. Bouaïcha N, Maatouk I. Microcystin-LR and nodularin induce intracellular glutathione alteration, reactive oxygen species production and lipid peroxidation in primary cultured rat hepatocytes.2004;: 53-63.
    Open DOISearch in Google Scholar
  17. Guzman ER, Solter PF. Hepatic oxidative stress following prolonged sublethal microcystin-LR exposure.1999;: 582-8.
    Open DOISearch in Google Scholar
  18. Žegura B, Lah TT, Filipič M. The role of reactive oxygen species in microcystin-LR-induced DNA damage.2004;: 59-68.
    Open DOISearch in Google Scholar
  19. Rao PV, Bhattacharaya R. The cyanobacteria toxin microcystin-LR induced DNA damage in mouse liver in vivo.1996;: 29-36.
    Open DOISearch in Google Scholar
  20. Maatouk I, Bouaïcha N, Plessis MJ, Perin F. Detection byP-postlabelling of 8-oxo-7,8-dihydro-2'-deoxyguanosine in DNA as biomarker of microcystin-LR- and nodularin-induced DNA damage in vitro in primary cultured rat hepatocytes and in vivo in rat liver.2004;: 9-20.
    Open DOISearch in Google Scholar
  21. Ding W-X, Shen H-M, Zhu H-G, Lee B-L. Genotoxicity of microcystic cyanobacteria extract of a water source in China.1999;: 69-77.
    Open DOISearch in Google Scholar
  22. Rao PV, Bhattacharaya R, Parida M M, Jana A M, Bhaskar A S. Freshwater cyanobacterium(UTEX 2385) induced DNA damageand1998;: 1-6.
    Open DOISearch in Google Scholar
  23. Žegura B, Sedmak B, Filipič M. Microcystin-LR induces oxidative DNA damage in human hepatoma cell line HepG2.2003; 41:-8
    Open DOISearch in Google Scholar
  24. Lankoff A, Krzowski L, Glab J, Banasik A, Lisowska H, Kuszewski T, et al. DNA damage and repair in human peripheral blood lymphocytes following treatment with microcystin-LR.2004;: 131-42.
    Open DOISearch in Google Scholar
  25. Zhan L, Sakamoto H, Sakuraba M, Wu D-S, Zhang L-S, Suzuki T, et al. Genotoxicity of microcystin-LR in human lymphobiastoid TK6 cells.2004;: 1-6.
    Open DOISearch in Google Scholar
  26. Suzuki H, Watanabe MF, Wu Y, Sugita T, Kita K, Sato T, et al. Mutagenicity of microcystin-LR in human RSa cells.1998;: 109-12.
    Open DOISearch in Google Scholar
  27. Tice RR, Agurel, E, Anderson D, Burlinson B., Hartmann A, Kobayashi H, et al. Single cell gel/comet assay: Guidelines for inandgenetic toxicology testing.2000;: 206-21.
    Open DOISearch in Google Scholar
  28. Harada KI, Matusura K, Suzuki M, Oka H, Watanabe MF, Oishi S, et al. Analysis and purification of toxic peptides from cyanobacteria by reversed-phase high-performance liquid chroma-tography.1988;: 275-84.
    Open DOISearch in Google Scholar
  29. de Sousa G, Delescluse C, Pralavorio M, Perichaud M, Avon M, Lafaurie M, Rahmani R. Toxic effects of several types of antifouling paints in human and rat hepatic or epidermal cells.1998;: 41-6.
    Open DOISearch in Google Scholar
  30. Pool-Zobel BL, Guigas C, Klein RG, Neudecker CH, Renner HW, Schnezer, P. Assessment of genotoxic effect by lindane.1993;: 271-83.
    Open DOISearch in Google Scholar
  31. Singh NP, McCoy MT, Tice RR, Schneider EL. A simple technique for quantitation of low levels of DNA damage in individual cells.1988;: 184-91.
    Open DOISearch in Google Scholar
  32. Milutinović A, Živin M, Zorc-Pleskovič R, Sedmak B, Šuput D. Nephrotoxic effects of chronic administration of microcystins -LR and -YR.2003;: 281-8.
    Open DOISearch in Google Scholar
  33. Moreno I, Pichardo S, Jos A, Gomez-Amores L, Mate A, Vazquez CM, Camean AM. Antioxidant enzyme activity and lipid peroxidation in liver and kidney of rats exposed to microcystin-LR administered intraperitoneally.2005;: 395-402.
    Open DOISearch in Google Scholar
  34. Maidana M, Carlis V, Galhardi FG, Yunes JS, Geracitano LA, Monserrat JM, Barros DM. Effects of microcystins over short- and long-term memory and oxidative stress generation in hippocampus of rats.2006;: 223-34.
    Open DOISearch in Google Scholar
  35. Fischer WJ, Altheimer S, Cattori V, Meier PJ, Dietrich DR, Hagenbuch B. Organic anion transporting polypeptides expressed in liver and brain mediate uptake of microcystin,2005;: 257-63.
    Open DOISearch in Google Scholar
  36. Walker AP, Bacherald HS. Studies on DNA damage and repair in mammalian brain,1988;: 1394-9.
    Open DOISearch in Google Scholar
  37. Gupta N, Pant SC, Vijayaraghavan R, Lakshmana Rao PV. Comparative toxicity evaluation of cyano-bacterial cyclic peptide toxin microcystin variants (LR, RR, YR) in mice.2003;: 285-96.
    Open DOISearch in Google Scholar
DOI: https://doi.org/10.2478/v10019-007-0003-z | Journal eISSN: 1581-3207 | Journal ISSN: 1318-2099
Journal RSS Feed
Language: English
Page range: 15 - 22
Published on: Apr 30, 2007
Published by: Association of Radiology and Oncology
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Keywords:
DNA damage,
comet assay,
cyanobacteria,
bacterial toxins,
rats,
inbred F344
Related subjects:
Medicine,
Clinical medicine,
Radiology

© 2007 Metka Filipič, Bojana Žegura, Bojan Sedmak, Irena Horvat-Žnidaršic, Aleksandra Milutinovič, Dušan Šuput, published by Association of Radiology and Oncology
This work is licensed under the Creative Commons License.

Volume 41 (2007): Issue 1 (March 2007)
Previous article
Next article