Simultaneous determination of methocarbamol and ibuprofen or diclofenac potassium using mean centering of the ratio spectra method

Nouruddin Ali; Maha Hegazy; Mohamed Abdelkawy; Eglal Abdelaleem

doi:10.2478/v10007-012-0016-z

.blurhash-client-img { display: none !important; }

Simultaneous determination of methocarbamol and ibuprofen or diclofenac potassium using mean centering of the ratio spectra method

Acta Pharmaceutica

Volume 62 (2012): Issue 2 (June 2012)

By: Nouruddin Ali, Maha Hegazy, Mohamed Abdelkawy and Eglal Abdelaleem

Open Access

|Jun 2012

Abstract

Accurate and sensitive methods were developed for simultaneous determination of methocarbamol and ibuprofen or diclofenac potassium in their binary mixtures, and in the presence of a methocarbamol related substance (guaifenesin) using mean centering of the ratio spectra method. The results obtained were statistically compared with the reported HPLC methods; no significant difference between the proposed methods and the reported methods was found regarding either accuracy or precision.

References

United States Pharmacopeia 30, National Formulary 25, USP Convention, Rockville (MD) 2007.
Search in Google Scholar
N. Pouli, A. Antoniadou-Vyzas and G. Foscolos, Methocarbamol degradation in aqueous solution, J. Pharm. Sci. 83 (1994) 499-501; DOI: 10.1002/jps.2600830411.10.1002/jps.2600830411
Search in Google Scholar
G. Subramanian, M. Vasudevan, S. Ravisankar and B. Suresh, Validation of a RP-LC method for simultaneous determination of paracetamol, methocarbamol and diclofenac potassium in tablets, Indian J. Pharm. Sci. 67 (2005) 260-263.
Search in Google Scholar
S. S. Zarapkar, U. P. Halkar and N. P. Bhandari, Reverse phase high performance liquid chromatographic determination of ibuprofen, paracetamol and methocatbamol in tablets, Indian Drugs 36 (1999) 710-713.
Search in Google Scholar
M. A. Rosasco, R. Ceresole, C. C. Forastieri and A. I. Segall, A stability indicating high-performance liquid chromatographic method for the determination of methocarbamol in veterinary preparations, J. AOAC Int. 92 (2009) 1602-1605; DOI: 10.5555/jaoi.92.5.1602.
Search in Google Scholar
A. Afkhami, T. Madrakian and L. Khalafi, Flow injection and batch spectrophotometric determination of ibuprofen based on its competitive complexation reaction with phenolphthalein β-cyclodextrin inclusion complex, Anal. Lett. 40 (2007) 2317-2328; DOI: 10.1080/00032710701575991.10.1080/00032710701575991
Search in Google Scholar
R. Leandro and T. Matthieu, Spectrophotometric determination of diclofenac in pharmaceutical preparations, J. Brazil. Chem. Soc. 16 (2005) 1068-1073; DOI: 10.1590/S0103-50532005000600026.10.1590/S0103-50532005000600026
Search in Google Scholar
N. Erk, Y. Ozkan, E. Banoglu, S. A. Ozkan and Z. Senturk, Simultaneous determination of paracetamol and methocarbamol in tablets by ratio spectra derivative spectrophotometry and LC, J. Pharm. Biomed. Anal. 24 (2001) 469-475; DOI: 10.1016/S0731-7085(00)00447-7.10.1016/S0731-7085(00)00447-7
Search in Google Scholar
A. B. Thomas, N. G. Dumbre, R. K. Nanda, L. P. Kothapalli and A. A. Chaudhari, Simultaneous determination of tramadol and ibuprofen in pharmaceutical preparations by first order derivative spectrophotometric and LC methods, Chromatographia 68 (2008) 843-847; DOI: 10.1365/s10337-008-0762-8.10.1365/s10337-008-0762-8
Search in Google Scholar
J. C. Duran-Alvarez, E. Becerril Bravo, V. S. Castro, B. Jimenez and R. Gibson, The analysis of a group of acidic pharmaceuticals, carbamazepine, and potential endocrine disrupting compounds in wastewater irrigated soils by gas chromatography-mass spectrometry, Talanta 78 (2009) 1159-1166; DOI: 10/1016/j.talanta.2009.01.035.10.1016/j.talanta.2009.01.03519269487
Search in Google Scholar
M. Walash, F. Belal, M. Eid and S. A. El Abass, Spectrofluorimetric determination of methocarbamol in pharmaceutical preparations and human plasma, J. Fluoresc. 21 (2011) 555-561; DOI: 10.1007/s10895-010-0742-x.10.1007/s10895-010-0742-x20936330
Search in Google Scholar
E. F. Elkady, Simultaneous spectrophotometric determination of diclofenac potassium and methocarbamol in binary mixture using chemometric techniques and artificial neural network, Drug Test. Anal. 3 (2011) 228-233; DOI: 10.1002/dta.216.10.1002/dta.21621500367
Search in Google Scholar
E. F. Elkady, Simultaneous determination of diclofenac potassium and methocarbamol in ternary mixture with guaifenesin by reversed phase liquid chromatography, Talanta 82 (2010) 1604-1607; DOI: 10.1016/j.talanta.2010.07.024.10.1016/j.talanta.2010.07.02420801380
Search in Google Scholar
A. Afkhami and M. Bahram., Mean centering of ratio spectra as a new spectrophotometric method for the analysis of binary and ternary mixtures, Talanta 66 (2005) 712-720; DOI: 10.1016/j.talanta.2004.12.004.10.1016/j.talanta.2004.12.00418970043
Search in Google Scholar
International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use, ICH Harmonized Tripartite Guideline, Validation of Analytical Procedures: Text and Methodology Q2(R1), Geneva 2005.
Search in Google Scholar

Articles in this issue

DOI: https://doi.org/10.2478/v10007-012-0016-z | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075

Journal RSS Feed

Language: English

Page range: 191 - 200

Published on: Jun 28, 2012

Published by: Croatian Pharmaceutical Society

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

methocarbamol,

diclofenac potassium,

ibuprofen,

mean centering of ratio spectra,

guaifenesin

Related subjects:

Pharmacy,

Pharmacy, other

© 2012 Nouruddin Ali, Maha Hegazy, Mohamed Abdelkawy, Eglal Abdelaleem, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons License.

Volume 62 (2012): Issue 2 (June 2012)