Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-ary1-8-alkyl pyrazolo(3,4-b)indoles

Adel Mandour; Eslam El-Sawy; Kamel Shaker; Mohamed Mustafa

doi:10.2478/v10007-010-0009-8

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Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-ary1-8-alkyl pyrazolo(3,4-b)indoles

Acta Pharmaceutica

Volume 60 (2010): Issue 1 (March 2010)

By: Adel Mandour, Eslam El-Sawy, Kamel Shaker and Mohamed Mustafa

Open Access

|Mar 2010

Abstract

A series of 1,8-dihydro-1-aryl-8-alkyl pyrazolo(3,4-b)indoles 4a-j, 5a-j and 6a-j has been synthesized and tested for their anti-inflammatory and anticonvulsant activities. Formation of the pyrazoloindole derivatives was achieved by treating arylhydrazones of N-alkyl indole-3-carbox-aldehydes 1a-j, 2a-j and 3a-j with ten times their mass of polyphosphoric acid as a condensing agent. The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anticonvulsant activities compared to indomethacin, flufenamic acid and diazepam as positive controls. Detailed synthesis, spectroscopic and toxicity data are reported.

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Articles in this issue

DOI: https://doi.org/10.2478/v10007-010-0009-8 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075

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Language: English

Page range: 73 - 88

Published on: Mar 13, 2010

Published by: Croatian Pharmaceutical Society

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

indole-3-carboxaldehyde,

anti-inflammatory activity,

anticonvulsant activity,

analgesic activity

Related subjects:

Pharmacy,

Pharmacy, other

© 2010 Adel Mandour, Eslam El-Sawy, Kamel Shaker, Mohamed Mustafa, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons License.

Volume 60 (2010): Issue 1 (March 2010)