Synthesis and preliminary screening of benzothiazol-2-yl thiadiazole derivatives for anticonvulsant activity

Nadeem Siddiqui; Arpana Rana; Suroor Khan; S. Haque; M. Arshad; Sharique Ahmed; Waquar Ahsan

doi:10.2478/v10007-009-0031-x

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Synthesis and preliminary screening of benzothiazol-2-yl thiadiazole derivatives for anticonvulsant activity

Acta Pharmaceutica

Volume 59 (2009): Issue 4 (December 2009)

By: Nadeem Siddiqui, Arpana Rana, Suroor Khan, S. Haque, M. Arshad, Sharique Ahmed and Waquar Ahsan

Open Access

|Nov 2009

Abstract

Various N-(5-chloro-6-substituted-benzothiazol-2-yl)-N'-(substituted phenyl)-[1,3,4]thiadiazole-2,5-diamines (5a-t) were designed and synthesized starting from substituted acetophenones. Structures of all the compounds were confirmed on the basis of spectral and elemental analyses. All the newly synthesized compounds were screened for their anticonvulsant activity and were compared with the standard drug phenytoin sodium. Interestingly, all the compounds showed protections against seizures in the range 50-100% indicative of the promising nature of the compounds against seizure spread. Compounds 5b and 5c showed complete protection against MES induced seizures.

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Articles in this issue

DOI: https://doi.org/10.2478/v10007-009-0031-x | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075

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Language: English

Page range: 441 - 451

Published on: Nov 16, 2009

Published by: Croatian Pharmaceutical Society

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

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© 2009 Nadeem Siddiqui, Arpana Rana, Suroor Khan, S. Haque, M. Arshad, Sharique Ahmed, Waquar Ahsan, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons License.

Volume 59 (2009): Issue 4 (December 2009)