Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori

Anwar Shaikh; Rajani Giridhar; Francis Megraud; Mange Yadav

doi:10.2478/v10007-009-0027-6

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Metalloantibiotics: Synthesis, characterization and antimicrobial evaluation of bismuth-fluoroquinolone complexes against Helicobacter pylori

Acta Pharmaceutica

Volume 59 (2009): Issue 3 (September 2009)

By: Anwar Shaikh, Rajani Giridhar, Francis Megraud and Mange Yadav

Open Access

|Oct 2009

Abstract

Novel organometallic compounds have been prepared by complexing the fluoroquinolones, norfloxacin, ofloxacin, ciprofloxacin, sparfloxacin, lomefloxacin, pefloxacin and gatifloxacin, with bismuth. The complexes were characterized by UV, IR, atomic absorption spectroscopy, elemental analysis, differential scanning calorimetry, thermogravimetric analysis and mass spectrometry. Their antibacterial potential against Helicobacter pylori and other microorganisms was investigated. These compounds were found to possess strong activity against Helicobacter pylori with a minimum inhibitory concentration of 0.5 mg L^-1. They also exhibited moderate activity against Escherichia coli, Staphylococcus aureus, Bacillus pumilus and Staphylococcus epidermidis. These bismuth-fluoroquinolone complexes have the potential to be developed as drugs against H. pylori related ailments.

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Articles in this issue

DOI: https://doi.org/10.2478/v10007-009-0027-6 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075

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Language: English

Page range: 259 - 271

Published on: Oct 9, 2009

Published by: Croatian Pharmaceutical Society

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

fluoroquinolone,

bismuth,

complex,

antimicrobial activity,

Helicobacter pylori

Related subjects:

Pharmacy,

Pharmacy, other

© 2009 Anwar Shaikh, Rajani Giridhar, Francis Megraud, Mange Yadav, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons License.

Volume 59 (2009): Issue 3 (September 2009)