Skip to main content
Have a personal or library account? Click to login
The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: Synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities Cover

The reaction of β-amino-α,γ-dicyanocrotononitrile with acetophenone: Synthesis of pyridine, pyridazine and thiophene derivatives with antimicrobial activities

Acta Pharmaceutica
Volume 58 (2008): Issue 4 (December 2008)
By: ,   and    
Open Access
|Dec 2008
References

References

  1. A. Bolognese, G. Correale, M. Manfra, A. Lavecchia, E. Novellino and S. Pepe, Antitumor agents. 5. Synthesis, structure-activity relationships, and biological evaluation of dimethyl-5-pyridophenoxazin-5-ones, tetrahydro-5-benzopyridophenoxazin-5-ones, and 5-benzopyridophenoxazin-5-ones with potent antiproliferative activity,49 (2006) 5110-5118; DOI: 10.1021/jm0507451.
    Search in Google Scholar
  2. G. Heimer, M. Rivlin-Etzion, I. Bar-Gad, J. A. Goldberg, S. N. Haber and H. Bergman, Dopamine replacement therapy does not restore the full spectrum of normal pallidal activity in the 1-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine primate model of Parkinsonism,26 (2006) 8101-8114; DOI: 10.1523/JNEUROSCI.5140-05.2006.
    Open DOISearch in Google Scholar
  3. R. Powers, J. C. Copland, K. Germer, K. A. Mercier, V. Ramanathan and P. Revesz, Comparison of protein active site structures for functional annotation of proteins and drug design,65 (2006) 124-135; DOI: 10.1002/prot.21092.
    Open DOISearch in Google Scholar
  4. F. M. Abdelrazek, F. A. Micheal and A. E. Mohamed; Synthesis and molluscicidal activity of some 1,3,4-triaryl-5-chloropyrazole, pyrano[2,3-c]pyrazole, pyrazolylphthalazine and pyrano[2,3-d]thiazole derivatives,339 (2006) 305-312; DOI: 10.1002/ardp.200500259.
    Open DOISearch in Google Scholar
  5. F. M. Abdelrazek and A. D. Fathy, A novel synthesis and molluscicidal activity of some functionally substituted pyridine, pyrido[3,2-c]pyridazine, and pyrido[3,2-c]pyridazino[2',3'-a]quinazoline derivatives,338 (2005) 329-334; DOI: 10.1002/ardp.200400938.
    Open DOISearch in Google Scholar
  6. S. Alias, R. Andreu, M. A. Cerdan, S. Franco, J. Garin, J. Orduna, P. Romero and B. Villacampa, Synthesis, characterization and optical properties of merocyanines derived from malononitrile dimer,48 (2007) 6539-6542; DOI: 10.1016/j.tetlet.2007.07.048.
    Open DOISearch in Google Scholar
  7. L. K. Wing, H. A. Behanna, L. J. Van Eldik, D. M. Watterson and R. H. Ralay, De novo and molecular target-independent discovery of orally bioavailable lead compounds for neurological disorders,3 (2006) 205-214; DOI: 10.2174/156720506777632844.
    Open DOISearch in Google Scholar
  8. E. Rozsa, H. Obotka, D. Nagy, T. Farkas, K. Saa, L. Vecsei and J. Toldi, The pentylenetetrazole-iduced acivity in the hippocampus can be inhibited by the conversion of 1-kynurenine to kynurenic acid: an in vitro study,76 (2008) 474-479; DOI: 10.1016/j.brainresbull.2007.12.001.
    Open DOISearch in Google Scholar
  9. E. Szarics, A. Simon, J. Visy, E. Simon-Trompler, Z. Banka, L. Heja, L. G. Harsing, G. Blasco, J. Kardos, L. Jeja, L. G. Harsing, G. Blasco and J. Kardos, Cyclothiazide binding to the GABAA receptor,439 (2008) 66-69; DOI: 10.1016/j.neulet.2008.04.092.
    Open DOISearch in Google Scholar
  10. K. Odlo, J. Hentzen, J. F. Chabert, S. Ducki, O. A. Gani, I. Sylte, M. Skrede, V. A. Florenes and T. V. Hanse, 1,5-Disubstituted 1,2,3-triazole as-restricted analogues of combrestastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin,16 (2008) 4829-4838; DOI: 10.1016/j.bmc.2008.03.049.
    Open DOISearch in Google Scholar
  11. H. Zhao, M. D. Serby, Z. Xin, B. G. Szczepankiewicz, M. Liu, C. Kosogof, B. Liu, L. T. Nelson, E. F. Johnson, S. Wang, T. Pederson, R. J. Gum, J. E. Clampit, D. L. Haasch, C. Abad-Zapatero, E. H. Fry, C. Rondinone, J. M. Trevillyan, H. L. Sham and G. Liu, Discovery of potent highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors,27 (2006) 4455-4458; DOI: 10.1021/jm0604651.
    Search in Google Scholar
  12. K. Muranaka, A. Sano, S. Ichikawa and A. Mastsuda, Synthesis of Hsp89 inhibitor dimmers as potential antitumer agents,16 (2008) 5862-5870; DOI: 10.1016/j.bmc.2008.04.070.
    Open DOISearch in Google Scholar
  13. A. Burguete, E. Pontiki, D. H. Litina, R. Villar, E. Vicente, B. Solano, S. Ancizu, S. Silanes, I. Aldana, A. Monge, Y. Maruyama, K. Anami and Y. Kotoh, Synthesis and anti-flammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1,4-di--oxide quinioxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1)-pyrazole analogues,17 (2007) 6439-6443; DOI: 10.1016/j.bmcl.2007.10.002.
    Open DOISearch in Google Scholar
  14. Y. Hirokawa, H. Kinoshita, T. Tanaka, T. Nakamura, K. Fujimoto, S. Kashimoto, T. Kojima and S. Kato, Pleuromutilin derivatives having a putine ring. Part 1: new compounds with promising antibacterial activity against resistant Gram-positive pathogens,18 (2008) 3556-3561; DOI: 10.1016/j.bmcl.2008.05.011.
    Open DOISearch in Google Scholar
  15. A. M. Palmer, B. Grobbel, C. Brehm, P. J. Zimmermann, W. Buhr, M. O Feth, H. C. Holst and W. A. Simon, Preparation of tetrahydroimidazo[2,1-a]isoquinolines and their use as inhibitors of gastric acid secretion,15 (2007) 7647-7660; DOI: 10.1016/j.bmc.2007.08.065.
    Open DOISearch in Google Scholar
  16. R. Leon, C. Rois, J. M. Contelles, M. G. Lopez, A. G. Barcia and M. Villaroya, Synthesis of 6-amino-1,4-dihydropyridines that prevent calcium overload and neuronal death,43 (2008) 668-674; DOI: 10.1016/j.ejmech.2007.06.001.
    Open DOISearch in Google Scholar
  17. J. Z. Yang, Y. Chen, A. M. Zhu, Q. L. Liu and J. Y. Wu, Analyzing diffusion behaviour of methanol/water through MFI membranes by molecular simulation,328 (2008) 327-333; DOI: 10.1016/j.memsci.2008,02,059.
    Search in Google Scholar
  18. Y. Z. Povstenko, Fractional radial diffusion ion in a cylinder,, 137 (2008) 46-50; DOI: 10.1016/j.molliq.2007,03.006.
    Search in Google Scholar
  19. H. Sterk and M. Mittelbach, The relaxational behaviour of nitrile groups,62 (1985) 175-181; DOI: 10.1016/0022-2364(85)90051-4.
    Open DOISearch in Google Scholar
  20. B. P. McKibben, C. H. Cartwright and A. L. Castelhano, Practicle synthesis of tetrasubstituted thiophenes for use in compound libraries,40 (1999) 5471-5474; DOI: 10.1016/S0040-4039(99)01108-9.
    Open DOISearch in Google Scholar
  21. P. Milart, J. Wilamowski and J. J. Sepiol, Synthesis of di- and triamino-1,1':3",1"-terphenyls from arylethylidene- and arylidenemalonodinitriles,54 (1998) 15643-15656; DOI: 10.1016/S0040-4020(98)00978-8.
    Open DOISearch in Google Scholar
DOI: https://doi.org/10.2478/v10007-008-0030-3 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
Journal RSS Feed
Language: English, Croatian
Page range: 429 - 444
Published on: Dec 22, 2008
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Keywords:
pyridine,
isoxazole,
pyridazine,
thiophene,
antimicrobial activity
Related subjects:
Pharmacy,
Pharmacy, other

© 2008 Rafat Mohareb, Karam El-Sharkawy, Sherif Sherif, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons License.

Volume 58 (2008): Issue 4 (December 2008)
Previous article
Next article