References
- H. Bräuner-Osborne, J. Egebjerg, E. Ø. Nielsen, U. Madsen and P. Krogsgaard-Larsen, Ligands for glutamate receptor: Design and therapeutic prospects, J. Med. Chem. 43 (2000) 2609-2645; DOI: 10.1021/jm000007r.
- R. Dingledine, K. Borges, D. Bowie and S. F. Traynelis, The glutamate receptor ion channels, Pharmacol. Rev. 51 (1999) 7-61.
- M. Hollmann and S. Heinemann, Cloned glutamate receptors, Annu. Rev. Neurosci. 17 (1994) 103-108.
- G. J. Lees, Pharmacology of AMPA/kainate receptor ligands and their therapeutic potential in neurological and psychiatric disorders, Drugs 59 (2000) 33-78; DOI: 10.2165/00003495-200059010-00004.
- U. Madsen, T. B. Stensbøl and P. Krogsgaard-Larsen, Inhibitors of AMPA and kainate receptors, Curr. Med. Chem. 8 (2001) 1291-1301.
- S. S. Nikam and B. E. Kornberg, AMPA receptor antagonists, Curr. Med. Chem. 8 (2001) 155-170.
- T. B. Stensbøl, U. Madsen and P. Krogsgaard-Larsen, The AMPA receptor binding site: Focus on agonists and competitive antagonists, Curr. Pharm. Des. 8 (2002) 857-872; DOI: 10.2174/1381612024607090.
- Y. P. Auberson, Competitive AMPA antagonism: A novel mechanism for antiepileptic drugs, Drugs Fut. 26 (2001) 463-471; DOI: 10.1358/dof.2001.026. 05.659545.
- S. D. Donevan and M. Rogawski, GYKI 52466, a 2,3-benzodiazepine, is a highly selective, non-competitive antagonist of AMPA/kainate receptor responses, Neuron 10 (1993) 51-59; DOI: 10.1016/0896-6273(93)90241-I.
- A. Tortorella, T. Halonen, N. Sahibzada and K. Gale, A crucial role of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype of glutamate receptors in piriform and perirhinal cortex for the initiation and propagation of limbic motor seizures, J. Pharmacol. Exp. Ther. 280 (1997) 1401-1405.
- W. Löscher, Pharmacology of glutamate receptor antagonists in the kindling model of epilepsy, Prog. Neurobiol. 54 (1998) 721-741; DOI: 10.1016/S0301-0082(97)00092-0.
- W. Loscher, H. Lehmann, B. Behl, D. Seemann, H. J. Teschendorf, H. P. Hofmann, W. Lubisch, T. Hoger, H. G. Lemaire and G. Gross, A new pyrrolyl-quinoxalinedione series of non-NMDA glutamate receptor antagonists: pharmacological characterization and comparison with NBQX and valproate in the kindling model of epilepsy, Eur. J. Neurosci. 11 (1999) 250-262; DOI: 10.1046/j.1460-9568.1999.00432.x.
- G. R. Desraju, B. Gopalakrishnan, R. K. Jetti, A. Nagarjun, D. Raveendra, J. A. Sarma, M. E. Sobhia and R. Thiagavathi, Computer-aided design of selective cox-2 inhibitors: comparative molecular field analysis, comparative molecular similarity indices analysis, and docking studies of some 1,2-diarylimidazole derivatives, J. Med. Chem. 45 (2002); DOI: 10.1021/jm020198t.
- M. T. Bohm. J. Sturzebecher and G. Klebe, Three dimensional quantitative structure activity relationship analysis using comparative molecular field analysis and comparative molecular similarity search analysis to elucidate selectivity differences of inhibitor binding to trypsin, thrombin and factor Xa, J. Med. Chem. 42 (1999) 458-477; DOI: 10.1021/jm981062r.
- D. Catarzi, V. Colotta, F. Varano, L. Cecchi, G. Filacchioni, A. Galli, C. Costagli and V. Carla, 7-Chloro-4,5-dihydro-8-(1,2,4-triazole-4-yl)-4-oxo-1,2,4-triazolo[1,5-a] quinoxaline-2-carboxylates as novel highly selective AMPA receptor antagonists, J. Med. Chem. 43 (2000) 3824-3826; DOI: 10.1021/jm0009686.
- D. Catarzi, V. Colotta, F. Varano, L. Cecchi, G. Filacchioni, V. R. Calabri, A. Galli, C. Costagli and V. Carla, Synthesis and biological evaluation of analogues of 7-chloro-4,5-dihydro-4-oxo-8-(1,2,4-triazol-4-yl)-1,2,4-triazolo[1,5-a] quinox -aline-2-carboxylic acid (TQX-173) as novel selective AMPA receptor antagonists, J. Med. Chem. 47 (2004) 262-272; DOI: 10.1021/jm030906q.
- D. Catarzi, V. Colotta, F. Varano, L. Cecchi, G. Filacchioni, A. Galli, C. Costagli and V. Carla, Synthesis, ionotropic glutamate receptor binding affinity, and structure-activity relationships of a new set of 4,5-dihydro-8-heteroaryl-4-oxo-1,2,4-triazolo[1,5-a] quinoxaline-2-carboxylates analogues of TQX-173, J. Med. Chem. 44 (2001) 3157-3165; DOI: 10.1021/jm010862q.
- F. Varano, D. Catarzi, V. Colotta, G. Filacchioni, A. Galli, C. Costagli and V. Carla, Synthesis and biological evaluation of a new set of pyrazolo[1,5-c]quinazoline-2-carboxylates as novel excitatory amino acid antagonists, J. Med. Chem. 45 (2002) 1035-1044; DOI: 10.1021/jm010995b.
- Y. C. Cheng and W. H. Prusoff, Relationship between the inhibition constant (Ki) and the concentration of inhibitor which causes 50% inhibition (IC50) of an enzymatic reaction, Biochem. Pharmacol. 22 (1973) 3099-3108; DOI: 10.1016/0006-2952(73)90196-2.