Have a personal or library account? Click to login
Improved dissolution of a poorly water soluble drug in solid dispersions with polymeric and non-polymeric hydrophilic additives Cover

Improved dissolution of a poorly water soluble drug in solid dispersions with polymeric and non-polymeric hydrophilic additives

By: Garima Chawla and  Arvind Bansal  
Open Access
|Dec 2008

References

  1. R. Lobenberg and G. L. Amidon, Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards, Eur. J. Pharm. Biopharm. 50 (2000) 3-12; DOI: 10.1016/S0939-6411(00)00091-6.10.1016/S0939-6411(00)00091-6
  2. H. Yan, S. E. Tabibi and S. H. Yalkowsky, Solubilization of two structurally related anticancer drugs: XK-469 and PPA, J. Pharm. Sci. 95 (2006) 97-107; DOI: 10.1002/jps.20500.10.1002/jps.20500
  3. L. F. Huang and W. Q. Tong, Impact of solid state properties on developability assessment of drug candidates, Adv. Drug Del. Rev. 56 (2004) 321-334; DOI: 10.1016/j.addr.2003.10.007.10.1016/j.addr.2003.10.007
  4. M. Pudipeddi and A. T. M. Serajuddin, Trends in solubility of polymorphs, J. Pharm. Sci. 94 (2005) 929-939; DOI: 10.1002/jps.20302.10.1002/jps.20302
  5. D. Q. M. Craig, The mechanisms of drug release from solid dispersions in water-soluble polymers, Int. J. Pharm. 231 (2002) 131-144; DOI: 10.1016/S0378-5173(01)00891-2.10.1016/S0378-5173(01)00891-2
  6. G. Chawla and A. K. Bansal, A comparative assessment of solubility advantage from glassy and crystalline forms of a water-insoluble drug, Eur. J. Pharm. Sci. 32 (2007) 45-57; DOI: 10.1016/j.ejps.2007.05.111.10.1016/j.ejps.2007.05.111
  7. C. J. Mbah, Kinetics of decomposition of irbesartan in aqueous solutions determined by high performance liquid chromatography, Pharmazie 59 (1994) 920-922.
  8. E. Garcia, C. Hoff and S. Veesler, Dissolution and phase transition of pharmaceutical compounds, J. Crys. Growth237-239 (2002) 2233-2239; DOI: 10.1016/S0022-0248(01)02282-5.10.1016/S0022-0248(01)02282-5
  9. S. Veesler, L. Lafferrere, E. Garcia and C. Hoff, Phase transitions in supersaturated drug solution, Org. Process Res. Develop. 7 (2003) 983-989; DOI: 10.1021/op034089f.10.1021/op034089f
  10. B. Law, S. L. Krill, E. A. Schmitt, J. J. Fort, Y. Qiu, W. Wang and W. R. Porter, Physicochemical considerations in the preparation of amorphous ritonavir-poly(ethylene glycol) 8000 solid dispersions, J. Pharm. Sci. 90 (2001) 1015-1025; DOI: 10.1002/jps.1054.10.1002/jps.105411536205
  11. V. B. Pokharkar, L. P. Mandpe, M. N. Padamwar, A. A. Ambike, K. R. Mahadik and A. Paradkar, Development, characterization and stabilization of amorphous form of a low Tg drug, Powder Technol. 167 (2006) 20-25; DOI: 10.1016/j.powtec.2006.05.012.10.1016/j.powtec.2006.05.012
  12. W. L. Chiou and S. Riegelman, Pharmaceutical applications of solid dispersion systems, J. Pharm. Sci. 60 (1971) 1281-1302; DOI: 10.1002/jps.2600600902.10.1002/jps.2600600902
  13. K. Danjo, T. Nakata and A. Otsuka, Preparation and dissolution behavior of ethenzamide solid dispersions using various sugars as dispersion carriers, Chem. Pharm. Bull. 45 (1997) 1840-1844.10.1248/cpb.45.1840
  14. A. Forster, J. Hempenstall and T. Rades, Characterization of glass solutions of poorly water-soluble drugs produced by melt extrusion with hydrophilic amorphous polymers, J. Pharm. Pharmacol. 53 (2001) 303-315; DOI: 10.1211/0022357011775532.10.1211/0022357011775532
  15. A. Modi and P. Tayade, Enhancement of dissolution profile by solid dispersion (kneading) technique, AAPS PharmSciTech. 7 (2006) E1-E6; DOI: 10.1208/pt070368.10.1208/pt070368
  16. P. R. Nassab, R. Rajko and P. S. Revesz, Physicochemical characterization of meloxicam-mannitol binary systems, J. Pharm. Biomed. Anal. 41 (2006) 1191-1197; DOI: 10.1016/j.jpba.2006.02.055.10.1016/j.jpba.2006.02.055
  17. M. J. Arias, J. R. Moyano and J. M. Gines, Study by DSC and HSM of the oxazepam-PEG 6000 and oxazepam-D-mannitol systems: Application to the preparation of solid dispersions, Thermochim. Acta 321 (1998) 33-41; DOI: 10.1016/S0040-6031(98)00437-7.10.1016/S0040-6031(98)00437-7
  18. P. Mura, M. T. Faucci, A. Manderioli, S. Furlanetto and S. Pinzauti, Thermal analysis as a screening technique in preformulation studies on picotinamide solid dosage forms, Drug Dev. Ind. Pharm. 24 (1998) 747-756; DOI: 10.3109/03639049809082722.10.3109/036390498090827229876522
  19. H. K. Chan, K. L. Au-Yeung and I. Gonda, Development of a mathematical model for the water distribution in freeze-dried solids, Pharmacol. Res. 16 (1999) 660-665; DOI: 10.1023A: 1018812305562.10.1023/A:1018812305562
  20. I. Weuts, D. Kempen, A. Decorte, G. Verreck, J. Peeters, M. Brewster and G. van den Mooter, Phase behaviour analysis of solid dispersions of loperamide and two structurally related compounds with the polymers PVP-K30 and PVP-VA64, Eur. J. Pharm. Sci. 22 (2004) 375-385; DOI: 10.1016/j.ejps.2004.04.002.10.1016/j.ejps.2004.04.00215265507
  21. M. Gordon and J. S. Taylor, Ideal copolymers and the second-order transitions of synthetic rubbers 1: Non-crystalline copolymers, J. Appl. Chem. 2 (1952) 493-498.
  22. H. Suzuki and H. Sunada, Comparison of nicotinamide, ethylurea and polyethylene glycol as carriers for nifedipine solid dispersion systems, Chem. Pharm. Bull. 46 (1998) 482-487.10.1248/cpb.46.4829549890
  23. A. Forster, T. Rades and J. Hempenstall, Selection of suitable drug and excipient candidates to prepare glass solutions by melt extrusion for immediate release oral formulations, Pharm. Technol. (Europe) (2002) 27-37.
  24. P. Sinswat, M. E. Matteucci, K. P. Johnston and R. O. Williams III, Dissolution rates and supersaturation behavior of amorphous repaglinide particles produced by controlled precipitation, J. Biomed. Nanotech. 3 (2007) 18-27; DOI: 10.1166/jbn.2007.001.10.1166/jbn.2007.001
  25. M. J. Arias, J. M. Gines, J. R. Moyano, J. I. Perez-Martinez and A. M. Rabasco, Influence of the preparation method of solid dispersions on their dissolution rate: Study of triamterene-D-mannitol system, Int. J. Pharm. 123 (1995) 25-31; DOI: 10.1016/0378-5173(95)00026-F.10.1016/0378-5173(95)00026-F
DOI: https://doi.org/10.2478/v10007-008-0016-1 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
Language: English
Page range: 257 - 274
Published on: Dec 22, 2008
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
Related subjects:

© 2008 Garima Chawla, Arvind Bansal, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons License.

Volume 58 (2008): Issue 3 (September 2008)