N-Phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats

Julija Matijević-Sosa; Ita Samaržija; Lorena Honović; Blaženka Jurišić

doi:10.2478/v10007-008-0010-7

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N-Phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats

Acta Pharmaceutica

Volume 58 (2008): Issue 2 (June 2008)

By: Julija Matijević-Sosa, Ita Samaržija, Lorena Honović and Blaženka Jurišić

Open Access

|May 2008

Abstract

The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg^-1 body mass) once a day for seven days, iron serum level decreased by 21%, whereas the iron value dropped by 32% in female rats (1.5 mg kg^-1 body mass). The results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possible.

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Articles in this issue

DOI: https://doi.org/10.2478/v10007-008-0010-7 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075

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Language: English

Page range: 231 - 236

Published on: May 30, 2008

Published by: Croatian Pharmaceutical Society

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

N-phthaloyl-glycine-hydroxamic acid,

Related subjects:

© 2008 Julija Matijević-Sosa, Ita Samaržija, Lorena Honović, Blaženka Jurišić, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons License.

Volume 58 (2008): Issue 2 (June 2008)