N-Phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats

Matijević-Sosa, Julija; Samaržija, Ita; Honović, Lorena; Jurišić, Blaženka

doi:10.2478/v10007-008-0010-7

Abstract

The aim of this study was to investigate the activity of N-phthaloyl-glycine-hydroxamic acid (Phth-Gly-HA) as a new iron chelator in vivo to be used in iron overload diseases. After intraperitoneal application of Phth-Gly-HA to male rats (1 mg kg^-1 body mass) once a day for seven days, iron serum level decreased by 21%, whereas the iron value dropped by 32% in female rats (1.5 mg kg^-1 body mass). The results indicate that the tested substance has the ability to bind serum iron by complexation. Besides transferrin iron release, mobilization of ferritin iron is also possible.

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N-Phthaloyl-glycine-hydroxamic acid as serum iron chelator in rats

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