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Anti-inflammatory and analgesic activities of some newly synthesized pyridinedicarbonitrile and benzopyranopyridine derivatives Cover

Anti-inflammatory and analgesic activities of some newly synthesized pyridinedicarbonitrile and benzopyranopyridine derivatives

By: Hanaa Hosni and  Mohamed Abdulla  
Open Access
|May 2008

References

  1. J. L. Soto, C. Seoane and J. A. Ciller, Synthesis of heterocycles. XVIII. Preparation of 2,4-diaryl-5-cyano-6-ethoxypyridines, An. Quim. Ser. C 76 (1980) 251-258.
  2. N. Mishriky, F. M. Aassad, Y. A. Ibrahim and A. S. Girgis, New pyridinecarbonitriles from fluoroarylpropenones, Recl. Trav. Chim. Pays-Bas 113 (1994) 35-39.10.1002/recl.19941130105
  3. M. M. Al-Arab, H. D. Tabba, B. S. Ghanem and M. M. Olmstead, Michael-addition of malononitrile to 1,3-diaryl-2-propen-1-ones, Synthesis 12 (1990) 1157-1159; DOI: 10.1055/s-1990-27123.10.1055/s-1990-27123
  4. M. M. Al-Arab, A facile synthesis of 6-alkoxy-2,4-diaryl-5-cyanopyridine, J. Heterocyclic Chem. 26 (1989) 1665-1673.10.1002/jhet.5570260629
  5. D. V. Tymdall, T. Al-Nakib and M. J. Meegan, A novel synthetic route to phenyl-substituted pyridines synthesis of [1]benzopyrano[3,4-b]pyridines, [1]benzothiopyrano[4,3-b]pyridines and pyrido[3,2-b]benzothiazines(1-azaphenothiazines), Tetrahedron Lett. 29 (1988) 2703-2706; DOI: 10.1016/0040-4039(91)85063-B.10.1016/0040-4039(91)85063-B
  6. Yu. A. Sharanin, V. K. Promonenkov and A. M. Shestopalov, Nitrile cyclization reactions. V. 2-Aryl-3-(2-thienoyl)-1,1-dicyanopropanes and derivatives of pyridines made from them, Zh. Org. Khim. 16 (1980) 2188-2192.
  7. P. C. Unangst, T. Capiris, D. T. Connor, T. G. Heffiner, R. G. Mackenzie, S. R. Miller, T. A. Pugsley and L. D. Wise, Chromeno[3,4-c]pyridine-5-ones: Selective human dopamine D4 receptor antagonists as potential antipsychotic agents, J. Med. Chem. 40 (1997) 2688-2693; DOI: 10.1021/im970397q.
  8. P. Koeckritz, C. Ruhmann, D. Fieblinger, C. D. Schroeder, B. Joksch, H. Heider, B. Weiher and J. Liebscher, Preparation of 2-aminopyridine-3-carbonitriles as human cyclomegalovirus inhibitors, Ger. Offen DE 4, 117, 802, 3 Dec 1992; ref. Chem. Abstr. 118 (1993) 191550s.
  9. S. K. Srivastava, R. P. Tripathi and R. J. Ramachandram, NAD+-dependent DNA ligase (Rv 3014 c) from Mycobacterium tuberculosis - crystal structure of the adenylation domain and identification of novel inhibitors, J. Biol. Chem. 80 (2005) 30272-30281; DOI: 10.1074/jbc.M503780200.10.1074/jbc.M503780200
  10. R. M. Weier, L. F. Lee, R. A. Partis and F. J. Koszyk, Preparation of 2,3-substituted pyridines for the treatment of inflammation, U.S. Pat. 96, 24, 584, 15 Aug 1996; ref. Cem. Abstr. 125 (1996) 247624h.
  11. B. E. Maurizio, H. T. Gerda, K. G. John and N. R. David, Preparation of pyrimidinamines and pyridinamines as adenosine receptor modulators for treatment of CNS disorders, Int. App. WO 0162, 233, 30 Aug 2001; ref. Chem. Abstr. 135 (2001) 2110495s.
  12. U. Eisner and J. Kuthan, The chemistry of dihydropyridines, Chem. Rev. 72 (1972) 1-42; DOI: 10.1021/cr60275a001.10.1021/cr60275a001
  13. J. M. Ouintela, C. Peinador, L. Botana, M. Estevez and R. Reiguera, Synthesis and antihistaminic activity of 2-guanadino-3-cyanopyridines and pyrido[2,3-d]pyrimidines, Bioorg. Med. Chem. 5 (1997) 1543-1553; DOI: 10.1016/S0968-0896(97)00108-9.10.1016/S0968-0896(97)00108-9
  14. F. Monna, F. Chimenti, A. Balasco, B. Bizzarri, W. Filippelli, A. Filippelli and L. Gagliardi, Antiinflammatory, analgesic and antipyretic of 4,6-disubstituted 3-cyano-2-aminopyridines, Eur. J. Med. Chem. 34 (1999) 245-254; DOI: 10.1016/S0223-5234(99)80057-9.10.1016/S0223-5234(99)80057-9
  15. K. Ueno, A. Sasaki, K. Kawano, T. Okabe, N. Kitazawa, K. Takahashi, N. Yamamoto and Y. Suzuki, Preparation of Piperazinylisoquinolines and Analogs as Serotonin Antagonists, 15 Apr 1999 Int. Appl. WO 99 180 77; ref. Chem. Abstr. 130 (1999) 311813b.
  16. R. C. Elderfied and T. P. King, Benzopyrylium salt by hydrocarbon elimination from chromens, J. Am. Chem. Soc. 76 (1954) 5439-5442; DOI: wiley.com/10.1002/9780470145173.ch263.10.1021/ja01650a054
  17. C. A. Winter, E. A. Risely and G. W. Nuss, Anti-infalmmatory and antipyretic activities of indomethacin, 1-(p-chlorobenzyl)-5-methoxy-2-methyl-indole-3-acetic acid, J. Pharmacol. Exp. Ther. 141 (1963) 369-376.
  18. K. U. Weithmann, S. Jeske and V. Schlotte, Effect of leflunomide on constitutive and inducible pathways of cellular eicosanoid generation, Agent Actions 41 (1994) 164-170; DOI: 10.1007/BF02001911.10.1007/BF020019117942324
  19. A. Tjlsen, J. H. Rosland, O. G. Berge and K. Hole, The increasing temperature hot plate test: An improved test of nociception in mice and rats, J. Pharmacol. Meth. 25 (1991) 241-250; DOI: 10.1016/0160-5402(91)90014-V.10.1016/0160-5402(91)90014-V
  20. K. F. Austen and W. E. Brocklehurst, Anaphylaxis in chopped guinea pig lung. I. Effect of peptidase substrates and inhibitors, J. Exp. Med. 113 (1961) 521-524.10.1084/jem.113.3.521213736813685194
  21. N. Mishriky, Y. A. Ibrahim and A. S. Girgis, Synthetic approaches towards 5H-indeno[1,2-b]pyridines, J. Chem. Res. 1997, 316-317; DOI: 10.1039/a608311k.10.1039/a608311k
  22. N. Mishriky, Y. A. Ibrahim, A. S. Girgis and N. G. Fawzy, Synthetic approaches towards benzo[h]quinoline-3-carbonitrile, Pharmazie 55 (2000) 269-272.
  23. A. S. Girgis and I. S. Ahmed-Farag, Synthesis of novel 2-alkoxy-5H-benzo[6,7]cyclo-hepta[1, 2-b]pyridine-3-carbonitriles, Z. Naturforsch. 58B (2003) 698-703; DOI: 0932-0776/03/0700-0698.10.1515/znb-2003-0716
DOI: https://doi.org/10.2478/v10007-008-0005-4 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075
Language: English
Page range: 175 - 186
Published on: May 30, 2008
Published by: Croatian Pharmaceutical Society
In partnership with: Paradigm Publishing Services
Publication frequency: 4 issues per year
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© 2008 Hanaa Hosni, Mohamed Abdulla, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons License.

Volume 58 (2008): Issue 2 (June 2008)