Synthesis and pharmacological activities of some condensed 4-chloro-2,2-dialkyl chromene-3-carbaldehyde derivatives

Mohamed Hegab; Nabil Yousef; Hany Nour; Mohey Ellithey; Mahmoud Arbid

doi:10.2478/v10007-007-0042-4

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Synthesis and pharmacological activities of some condensed 4-chloro-2,2-dialkyl chromene-3-carbaldehyde derivatives

Acta Pharmaceutica

Volume 58 (2008): Issue 1 (March 2008)

By: Mohamed Hegab, Nabil Yousef, Hany Nour, Mohey Ellithey and Mahmoud Arbid

Open Access

|Mar 2008

Abstract

Some new hydrazono 5a,b, thiosemicarbazono 6a-c, and oximo chromenes 7a-c were prepared via the reaction of the corresponding β-chlorocarbaldehyde 3 with hydrazine, aromatic hydrazine, thiosemicarbazide and hydroxylamine hydrochloride, respectively. In addition, ether derivatives 8a-h were prepared from the corresponding aldoximes 7a-c. The new products were tested for anti-inflammatory and ulcerogenic score activities compared to indomethacin.

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Articles in this issue

DOI: https://doi.org/10.2478/v10007-007-0042-4 | Journal eISSN: 1846-9558 | Journal ISSN: 1330-0075

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Language: English

Page range: 15 - 27

Published on: Mar 12, 2008

Published by: Croatian Pharmaceutical Society

In partnership with: Paradigm Publishing Services

Publication frequency: 4 issues per year

Keywords:

ulcerogeno djelovanje

Related subjects:

Pharmacy,

Pharmacy, other

© 2008 Mohamed Hegab, Nabil Yousef, Hany Nour, Mohey Ellithey, Mahmoud Arbid, published by Croatian Pharmaceutical Society
This work is licensed under the Creative Commons License.

Volume 58 (2008): Issue 1 (March 2008)