
3-D Structure of Serum Paraoxonase 1 Sheds Light on Its Activity, Stability, Solubility and Crystallizability
By: Michal Harel, Boris Brumshtein, Ran Meged, Hay Dvir, Raimond Ravelli, Andrew McCarthy, Lilly Toker, Israel Silman and Joel Sussman
Open Access
|Oct 2007References
- Draganov DI, La Du BN. Pharmacogenetics of paraoxonases: a brief review.2004;369:78-88.
- Lusis AJ. Atherosclerosis.2000;407:233-41.
- Shih DM, Gu L, Xia YR, Navab M, Li WF, Hama S, Castellani LW, Furlong CE, Costa LG, Fogelman AM, Lusis AJ. Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosis.1998;394:284-7.
- Mackness MI, Arrol S, Durrington PN. Paraoxonase prevents accumulation of lipoperoxides in low-density lipoprotein.1991;286:152-4.
- Reddy ST, Wadleigh DJ, Grijalva V, Ng C, Hama S, Gangopadhyay A, Shih DM, Lusis AJ, Navab M, Fogelman AM. Human paraoxonase-3 is an HDL-associated enzyme with biological activity similar to paraoxonase-1 protein but is not regulated by oxidized lipids.2001;21:542-7.
- Rodrigo L, Mackness B, Durrington PN, Hernandez A, Mackness MI. Hydrolysis of platelet-activating factor by human serum paraoxonase.2001;354:1-7.
- Ahmed Z, Ravandi A, Maguire GF, Emili A, Draganov D, La Du BN, Kuksis A, Connelly PW. Apolipoprotein A-I promotes the formation of phosphatidylcholine core aldehydes that are hydrolyzed by paraoxonase (PON-1) during high density lipoprotein oxidation with a peroxynitrite donor.2001;276:24473-81.
- Jakubowski H. Calcium-dependent human serum homocysteine thiolactone hydrolase. A protective mechanism against protein N-homocysteinylation.2000;275:3957-62.
- Lund-Katz S, Liu L, Thuahnai ST, Phillips MC. High density lipoprotein structure.2003;8: d1044-54.
- Fuhrman B, Volkova N, Aviram M. Oxidative stress increases the expression of the CD36 scavenger receptor and the cellular uptake of oxidized low-density lipoprotein in macrophages from atherosclerotic mice: protective role of antioxidants and of paraoxonase.2002;161:307-16.
- Rozenberg O, Shih DM, Aviram M. Human serum paraoxonase 1 decreases macrophage cholesterol biosynthesis: possible role for its phospholipase-A2-like activity and lysophosphatidylcholine formation.2003;23:461-7.
- Sorenson RC, Bisgaier CL, Aviram M, Hsu C, Billecke S, La Du BN. Human serum Paraoxonase/Arylesterase's retained hydrophobic N-terminal leader sequence associates with HDLs by binding phospholipids: apolipoprotein A-I stabilizes activity.1999;19:2214-25.
- Aharoni A, Gaidukov L, Yagur S, Toker L, Silman I, Tawfik DS. Directed evolution of mammalian paraoxonases PON1 and PON3 for bacterial expression and catalytic specialization.2004;101:482-7.
- Harel M, Aharoni A, Gaidukov L, Brumshtein B, Khersonsky O, Meged R, Dvir H, Ravelli RB, McCarthy A, Toker L, Silman I, Sussman JL, Tawfik DS. Structure and evolution of the serum paraoxonase family of detoxifying and anti-atherosclerotic enzymes.2004;11:412-9.
- Morales R, Berna A, Carpentier P, Contreras-Martel C, Renault F, Nicodeme M, Chesne-Seck ML, Bernier F, Dupuy J, Schaeffer C, Diemer H, Van-Dorsselaer A, Fontecilla-Camps JC, Masson P, Rochu D, Chabriere E. Discovery and crystallographic structure of human apolipoprotein.2000;65:98-107.
- Josse D, Ebel C, Stroebel D, Fontaine A, Borges F, Echalier A, Baud D, Renault F, Le Maire M, Chabriere E, Masson P. Oligomeric states of the detergent-solubilized human serum paraoxonase (PON1).2002;277:33386-97.
- Rosenblat M, Gaidukov L, Khersonsky O, Vaya J, Oren R, Tawfik DS, Aviram M. The catalytic His dyad of High Density Lipoprotein-associated serum paraoxonase-I (PON1) is essential for PON1-mediated inhibition of Low Density Lipoprotein oxidation and stimulation of macrophage cholesterol efflux.2006;281:7657-66.
- Khersonsky O, Tawfik DS. The histidine-115 histidine-134 dyad mediates the lactonase activity of mammalian serum paraoxonases.2006;281:7649-56.
- Kuo CL, La Du BN. Comparison of purified human and rabbit serum paraoxonases.1995;23:935-44.
- Roodveldt C, Aharoni A, Tawfik DS. Directed evolution of proteins for heterologous expression and stability.2005;15:50-6.
- Sekar K, Yu BZ, Rogers J, Lutton J, Liu X, Chen X, Tsai MD, Jain MK, Sundaralingam M. Phospholipase A2 engineering. Structural and functional roles of the highly conserved active site residue aspartate-99.1997;36:3104-14.
- Scharff EI, Koepke J, Fritzsch G, Lucke C, Ruterjans H. Crystal structure of diisopropylfluorophosphatase fromStructure (Camb) 2001;9:493-502.
- Waldo GS. Genetic screens and directed evolution for protein solubility.2003;7:33-8.
- Roodveldt C, Tawfik DS. Directed evolution of phosphotriesterase fromfor heterologous expression incoli results in stabilization of the metal-free state.2005;18:51-583.
DOI: https://doi.org/10.2478/v10004-007-0028-0 | Journal eISSN: 1848-6312 (formerly 0004-1254) | Journal ISSN: 0004-1254
Language: English, Croatian
Page range: 347 - 353
Published on: Oct 3, 2007
Published by: Institute for Medical Research and Occupational Health
In partnership with: Paradigm Publishing Services
Related subjects:
© 2007 Michal Harel, Boris Brumshtein, Ran Meged, Hay Dvir, Raimond Ravelli, Andrew McCarthy, Lilly Toker, Israel Silman, Joel Sussman, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons License.