Skip to main content
Have a personal or library account? Click to login
Structure-Activity Approach in the Reactivation of Tabun-Phosphorylated Human Acetylcholinesterase with Bispyridinium para-Aldoximes Cover

Structure-Activity Approach in the Reactivation of Tabun-Phosphorylated Human Acetylcholinesterase with Bispyridinium para-Aldoximes

Archives of Industrial Hygiene and Toxicology
Volume 58 (2007): Issue 2 (June 2007)
By: ,  ,   and    
Open Access
|Jun 2007
References

References

  1. Gray AP. Design and structure-activity relationships of antidotes to organophosphorus anticholinesterase agents.1984;15, 557-89.
    Open DOISearch in Google Scholar
  2. Stojiljković MP, Jokanović M. Pyridinium oximes: rationale for their selection as causal antidotes against organophosphate poisonings and current solutions for auto-injectors.2006;57:435-43.
    Search in Google Scholar
  3. Čalić M, Lucić Vrdoljak A, Radić B, Jelić D, Jun D, Kuča K, Kovarik Z.andevaluation of pyridinium aldoximes: mode of interaction with acetylcholinesterase, effect on tabun- and soman-poisoned mice and their cytotoxicity.2006;219:85-96.
    Open DOISearch in Google Scholar
  4. Lucić Vrdoljak A, Čalić M, Radić B, Berend S, Jun D, Kuča K, Kovarik Z. Pretreatment with pyridinium aldoximes improves antidotal therapy against tabun poisoning.2006;228:41-50.
    Open DOISearch in Google Scholar
  5. Simeon-Rudolf V, Reiner E, Škrinjarić-Špoljar M, Radić B, Lucić A, Primožić I, Tomić S. Quinuclidinium-imidazolium compounds: synthesis, mode of interaction with acetylcholinesterase and effect upon soman intoxicated mice.1998;72:289-95.
    Open DOISearch in Google Scholar
  6. Škrinjarić-Špoljar M, Burger N, Lovrić J. Inhibition of acetylcholinesterase by three new pyridinium compounds and their effect on phosphonylation of the enzyme.1999;14:331-41.
    Open DOISearch in Google Scholar
  7. Kovarik Z, Bosak A, Šinko G, Latas T. Exploring active sites of cholinesterases by inhibition with bambuterol and haloxon.2003;76:63-7.
    Search in Google Scholar
  8. Šinko G, Bosak A, Kovarik Z, Simeon-Rudolf V. Structure-inhibition relationships in the interaction of butyrylcholinesterase with bambuterol, haloxon and their leaving groups.2005;157-158:421-3.
    Open DOISearch in Google Scholar
  9. Ellman GL, Courtney KD, Andres VJr, Featherstone RM. New and rapid colorimetric determination of acetylcholinesterase activity.1961;7:88-95.
    Open DOISearch in Google Scholar
  10. Eyer P, Worek F, Kiderlen D, Šinko G, Štuglin A, Simeon-Rudolf V, Reiner E. Molar absorption coefficients for the reduced Ellman reagent: reassessment.2003;312:224-7.
    Open DOISearch in Google Scholar
  11. Šinko G, Čalić M, Kovarik Z.- and-Pyridinium aldoximes in reaction with acetylthiocholine.2006;580:3167-72.
    Open DOISearch in Google Scholar
  12. Odžak R, Čalić M, Hrenar T, Primožić I, Kovarik Z. Evaluation of monoquaternary pyridinium aldoximes potency to reactivate tabun-inhibited human acetylcholinesterase.2006;233:85-96.
    Open DOISearch in Google Scholar
  13. Kovarik Z, Radić Z, Berman HA, Simeon-Rudolf V, Reiner E, Taylor P. Mutant cholinesterases possessing enhanced capacity for reactivation of their phosphonylated conjugates.2004;43:3222-9.
    Open DOISearch in Google Scholar
  14. Heilbronn E. In vitro reactivation and "aging" of tabun-inhibited blood cholinesterases studied with N-methyl-pyridinium-2-aldoxime methane sulphonate and N,N'-trimethylene bis (pyridinium-4-aldoxime) dibromide.1963;12:25-36.
    Open DOISearch in Google Scholar
  15. Ashani Y, Bhattacharjee AK, Leader H, Saxena A, Doctor BP. Inhibition of cholinesterase with cationic phosphonyl oximes highlights distinctive properties of the charged pyridine groups of quaternary oxime reactivators.2003;33:191-202.
    Open DOISearch in Google Scholar
  16. Francisković L, Škrinjarić-Špoljar M, Reiner E. Interaction of imidazolium and pyridinium dioximes with human erythrocyte acetylcholinesterase.1993;87:323-8.
    Open DOISearch in Google Scholar
  17. Kuča K, Patočka J, Cabal J. Reactivation of organophosphate inhibited acetylcholinesterase activity by α, ω-bis-(hydroxyiminomethylpyridinium)alkanes2003;1:207-11.
    Open DOISearch in Google Scholar
  18. Worek F, Thiermann H, Szinicz L, Eyer P. Kinetic analysis of interactions between human acetylcholineserase, structurally different organophosphorus compounds and aldoximes.2004;68:2237-48.
    Open DOISearch in Google Scholar
  19. Pang Y-P, Kollmeyer TM, Hong F, Lee J, Hammond PI, Haugabouk SP, Brimijoin S. Rational design of alkylene-linked bis-pyridiniumaldoximes as improved acetylcholinesterase reactivators.2003;10:491-502.
    Open DOISearch in Google Scholar
  20. Ekström F, Pang Y-P, Boman M, Artursson E, Akfur C, Börjegren S. Crystal structures of acetylcholinesterase in complex with HI-6, Ortho-7 and obidoxime: Structural basis for differences in the ability to reactivate tabun conjugates.2006;72:597-607.
    Open DOISearch in Google Scholar
  21. Bosak A, Primožić I, Oršulić M, Tomić S, Simeon-Rudolf V. Enantiomers of quinuclidin-3-ol derivates: resolution and interactions with human cholinesterases.2005;78:121-8.
    Search in Google Scholar
  22. Simeon V, Radić Z, Reiner E. Inhibition of cholinesterase by the aldoximes P2AM and toxogonin.1981;54:473-80.
    Search in Google Scholar
  23. Škrinjarić-Špoljar M, Simeon V, Reiner E, Krauthacker B. Bispyridinium compounds: inhibition of human erythrocyte acetylcholinesterase and protection of the enzyme against phosphylation.1988;38:101-9.
    Search in Google Scholar
  24. Kovarik Z, Ciban N, Radić Z, Simeon-Rudolf V, Taylor P. Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP.2006;342:973-8.
    Open DOISearch in Google Scholar
  25. Reiner E. Inhibition of acetylcholinesterase by 4,4'-bipyridine and its effect upon phosphylation of the enzyme.1986;59:925-31.
    Search in Google Scholar
DOI: https://doi.org/10.2478/v10004-007-0013-7 | Journal eISSN: 1848-6312 (formerly 0004-1254) | Journal ISSN: 0004-1254
Journal RSS Feed
Language: English, Croatian
Page range: 201 - 209
Published on: Jun 11, 2007
Published by: Institute for Medical Research and Occupational Health
In partnership with: Paradigm Publishing Services
Keywords:
antidotes,
nerve agents,
organophosphorus compounds
Related subjects:
Medicine,
Basic medical science,
Basic medical science, other

© 2007 Zrinka Kovarik, Maja Čalić, Goran Šinko, Anita Bosak, published by Institute for Medical Research and Occupational Health
This work is licensed under the Creative Commons License.

Volume 58 (2007): Issue 2 (June 2007)
Previous article
Next article